| Arbor Financial Credit Union | Kalamazoo | — | $50.2M | 11 |
| BARUCH SLS INC | Grand Rapids | L99 Housing & Shelter | $50.2M | 3 |
| ALPENA ALCONA AREA CREDIT UNION | Alpena | — | $50M | 7 |
| ARAB COMMUNITY CENTER FOR ECONOMIC AND S | Dearborn | P280 Human Services | $49.5M | 5 |
| FUND FOR MEDICAL RESEARCH AND EDUCATION | Detroit | — | $49.5M | 24 |
| My Community Dental Centers Inc | Petoskey | E300 Health Care | $49.3M | 10 |
| BAKER COLLEGE PROFESSIONAL SERVICES | Owosso | B42 Education | $48.6M | 12 |
| PFCU | Portland | — | $48.6M | 7 |
| DORSEY COLLEGE HOLDINGS | Madison Heights | B40 Education | $48.1M | 10 |
| BALDWIN FAMILY HEALTH CARE INC | Baldwin | — | $48.1M | 11 |
| UNITED JEWISH FOUNDATION | Bloomfield Hills | T70 Philanthropy, Voluntarism & Grantmaking Foundations | $48M | 9 |
| MICHIGAN HEALTH INFORMATION NETWORK SHARED SERVICES | Lansing | E800 Health Care | $47.3M | 24 |
| DETROIT ATHLETIC CLUB | Detroit | — | $47.3M | 8 |
| LIFE FOR RELIEF AND DEVELOPMENT INC | Southfield | Q330 International, Foreign Affairs & National Security | $47.3M | 1 |
| STARFISH FAMILY SERVICES INC | Inkster | P400 Human Services | $47.1M | 6 |
| PLUMBERS & PIPEFITTERS LOCALS 502 & 633 HEALTH & WELFARE TRUST FUND | Troy | — | $47M | 4 |
| GREENPATH INC | Farmington Hills | P51Z Human Services | $46.9M | 12 |
| MARLETTE REGIONAL HOSPITAL | Marlette | E22Z Health Care | $46.5M | 8 |
| CNS HEALTHCARE | Novi | F60 Mental Health & Crisis Intervention | $46.4M | 32 |
| GOODWILL INDUSTRIES OF GREATER GRAND RAPIDS INC | Grandville | J320 Employment | $45.7M | 8 |
| GLEANER LIFE INSURANCE SOCIETY | Adrian | — | $45M | 32 |
| KALAMAZOO FOUNDATION FOR EXCELLENCE | Kalamazoo | W11 Public & Societal Benefit | $44.9M | 1 |
| UNITED METHODIST RETIREMENT COMMUNITIES INC | Chelsea | P75 Human Services | $44.9M | 10 |
| Hospice Care of Southwest Michigan | Kalamzoo | P74Z Human Services | $44.5M | 17 |
| HELEN NEWBERRY JOY HOSPITAL & HEALTHCARE CENTER | Newberry | E22 Health Care | $44.5M | 17 |
| TEAM ONE CREDIT UNION | Saginaw | — | $44.3M | 13 |
| OMNI COMMUNITY CREDIT UNION | Battle Creek | — | $44.3M | 7 |
| BRONSON SOUTH HAVEN HOSPITAL | Kalamazoo | Z99 Unknown | $43.9M | 17 |
| DEARBORN SCHOOLS EMPLOYEE HEALTHCARE PROGRAM VOLUN | Dearborn | Y43 Mutual & Membership Benefit | $43.7M | 0 |
| ALLIANCE CATHOLIC CREDIT UNION | Farmington Hills | — | $43.6M | 9 |
| SPFPA AND PARTICIPATING EMPLOYERS HEALTH AND WELFARE TRUST FUND | Roseville | Y43 Mutual & Membership Benefit | $43.6M | 2 |
| CHRISTIAN FINANCIAL CREDIT UNION | Sterling Heights | — | $43.5M | 8 |
| AMERICAN LIGHTWEIGHT MATERIALS MANUFACTURING INNOVATION INSTITUTE | Detroit | U40 Science & Technology | $43.5M | 12 |
| IBEW LOCAL UNION 347 & NECA CHAPTER OF NECA BOARD OF TRUSTEES | Troy | — | $43.3M | 0 |
| EATON RAPIDS MEDICAL CENTER | Eaton Rapids | E22Z Health Care | $43.2M | 7 |
| Reliance Community Care Partners | Grand Rapids | E92Z Health Care | $43.2M | 2 |
| DETROIT 90 90 | Detroit | B02 Education | $43.1M | 8 |
| OLIVET COLLEGE | Olivet | B420 Education | $43M | 11 |
| MICHIGAN PEER REVIEW ORGANIZATION | Grand Rapids | E00D Health Care | $42.7M | 26 |
| The Wing Shadow Foundation | Ada | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $42.7M | 0 |
| Michigan Masonic Home | Alma | P750 Human Services | $42.1M | 7 |
| ASPIRUS IRON RIVER HOSPITAL & CLINICS INC | Iron River | E200 Health Care | $41.2M | 26 |
| THE HERBERT H & GRACE A DOW FOUNDATION | Midland | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $40.9M | 3 |
| KALAMAZOO COMMUNITY FOUNDATION | Kalamazoo | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $40.7M | 7 |
| DETROIT SYMPHONY ORCHESTRA INC | Detroit | A690 Arts, Culture & Humanities | $40.7M | 12 |
| TLC COMMUNITY CREDIT UNION | Adrian | — | $40.6M | 8 |
| LIFE CIRCLES | Muskegon | P80 Human Services | $40.3M | 8 |
| IRON WORKERS LOCAL 25 HEALTH CARE TRUST | Troy | — | $40.2M | 0 |
| SECURITY CREDIT UNION | Holly | — | $40.2M | 12 |
| THE HURLEY CLINICS | Flint | E31Z Health Care | $40M | 9 |
