| WELVISTA | Columbia | E70 Health Care | $101.2M | 7 |
| MCLEOD HEALTH CLARENDON | Florence | E22 Health Care | $91.6M | 12 |
| BLACK RIVER ELECTRIC COOPERATIVE INC | Sumter | — | $91.4M | 16 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA FOUNDATION | Charleston | H90 Medical Research | $88.9M | 2 |
| LUTHERAN HOMES OF SOUTH CAROLINA INC | Irmo | P750 Human Services | $88.8M | 8 |
| FAIRFIELD ELECTRIC COOPERATIVE INC | Blythewood | — | $87.9M | 17 |
| LOWCOUNTRY FOOD BANK INC | Charleston | — | $87.5M | 5 |
| University of South Carolina Educational Foundation | Columbia | B110 Education | $84.7M | 10 |
| Presbyterian Communities of South Carolina | Columbia | P750 Human Services | $82.8M | 8 |
| SOUTHERN MUTUAL CHURCH INSURANCE CO | Columbia | Y20Z Mutual & Membership Benefit | $80.3M | 17 |
| MYRTLE BEACH AREA CHAMBER OF COMMERCE | Myrtle Beach | — | $80M | 9 |
| MCLEOD MEDICAL CENTER DILLON | Florence | E220 Health Care | $79.8M | 13 |
| MCLEOD HEALTH CHERAW | Florence | E20 Health Care | $78.8M | 11 |
| IPTAY | Clemson | O50 Youth Development | $78.5M | 10 |
| MARLBORO ELECTRIC COOPERATIVE INC | Florence | — | $77.3M | 9 |
| EAU CLAIRE COOPERATIVE HEALTH CENTER INC | Columbia | — | $76.9M | 12 |
| PEE DEE ELECTRIC COOPERATIVE INC | Florence | — | $76.6M | 10 |
| CLEMSON UNIVERSITY FOUNDATION | Clemson | B11 Education | $75.3M | 6 |
| CLAFLIN UNIVERSITY | Orangeburg | B420 Education | $73.8M | 14 |
| Farm Credit Benefits Alliance Employee Welfare Benefit Trust | Columbia | Y43 Mutual & Membership Benefit | $73.4M | 1 |
| CARESOUTH CAROLINA INC | Hartsville | E320 Health Care | $73.2M | 9 |
| MPD ELECTRIC COOPERATIVE INC | Florence | W80 Public & Societal Benefit | $70.7M | 26 |
| North Greenville University | Tigerville | B410 Education | $70.2M | 10 |
| BENEDICT COLLEGE | Columbia | B420 Education | $69.7M | 7 |
| Presbyterian College | Clinton | L20Z Housing & Shelter | $67.9M | 16 |
| SOUTH CAROLINA FIRST STEPS TO SCHOOL READINESS BOARD OF TRUSTEES | Columbia | B012 Education | $66.2M | 6 |
| LYNCHES RIVER ELECTRIC COOPERATIVE INC | Pageland | — | $66.1M | 16 |
| Genesis Healthcare Inc | Columbia | E30 Health Care | $65.9M | 17 |
| PALMETTO GOODWILL | North Charleston | P20 Human Services | $65.1M | 9 |
| SOUTH CAROLINA STUDENT LOAN CORP | Columbia | W600 Public & Societal Benefit | $65M | 21 |
| BISHOP GADSDEN EPISCOPAL RETIREMENT COMMUNITY | Charleston | P750 Human Services | $63.2M | 13 |
| NATIONAL WILD TURKEY FEDERATION INC | Edgefield | C300 Environment | $63.1M | 10 |
| BROAD RIVER ELECTRIC COOPERATIVE INC | Cowpens | — | $62.3M | 15 |
| EDISTO ELECTRIC COOPERATIVE INC | Bamberg | W80 Public & Societal Benefit | $61.5M | 16 |
| Newberry College | Newberry | B420 Education | $61.3M | 8 |
| Columbia International University | Columbia | B500 Education | $60.5M | 8 |
| TRI-COUNTY ELECTRIC COOPERATIVE INC | St Matthews | — | $60.5M | 15 |
| SOUTH CAROLINA CONNECTIONS ACADEMY INC | Columbia | B99 Education | $60.4M | 0 |
| MUSC Affiliate Physicians | Charleston | F11 Mental Health & Crisis Intervention | $59.8M | 3 |
| GOODWILL INDUSTRIES OF UPSTATEMIDLANDS SOUTH CAROLINA INC | Greenville | J32Z Employment | $59.6M | 7 |
| NEWBERRY ELECTRIC COOPERATIVE INC | Newberry | — | $53.7M | 15 |
| BlueCross BlueShield of South Carolina Foundation | Columbia | T70 Philanthropy, Voluntarism & Grantmaking Foundations | $51.8M | 0 |
| HARVEST HOPE FOOD BANK | Columbia | K31Z Food, Agriculture & Nutrition | $50.5M | 6 |
| PEACE CENTER FOUNDATION | Greenville | A610 Arts, Culture & Humanities | $50.5M | 6 |
| LITTLE RIVER MEDICAL CENTER INC | Little River | E22Z Health Care | $49.7M | 11 |
| WE ARE SHARING HOPE SC | Charleston | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $49.3M | 8 |
| Spartanburg County Foundation | Spartanburg | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $48.6M | 4 |
| LIMESTONE UNIVERSITY | Gaffney | B42Z Education | $47M | 9 |
| MEETING STREET SCHOOLS | Charleston | B82 Education | $47M | 10 |
| Erskine College and Theological Seminary | Due West | B420 Education | $46.6M | 5 |
