| URBAN STRATEGIES INC | Saint Louis | P80 Human Services | $16.6M | 8 |
| Providence Hospital | St Louis | E21 Health Care | $16.5M | 11 |
| ST CATHERIN LABOURE MANOR INC | St Louis | — | $16.5M | 8 |
| COMMUNITY LIVING INC | Saint Peters | P820 Human Services | $16.5M | 1 |
| BONIFACE FOUNDATION | St Louis | E110 Health Care | $16.5M | 1 |
| The Baptist Home Inc | Jefferson City | P750 Human Services | $16.4M | 1 |
| UFCW UNION LOCAL 88 & EMPLOYERS HEALTH & | St Louis | Y430 Mutual & Membership Benefit | $16.3M | 0 |
| VETERANS COMMUNITY PROJECT | Kansas City | W30 Public & Societal Benefit | $16.3M | 7 |
| ST VINCENT HOSPITAL FOUNDATION INC | St Louis | E110 Health Care | $16.3M | 4 |
| CLARK RICHARDSON & BISKUP CONSULTING | Kansas City | U40 Science & Technology | $16.2M | 0 |
| GREAT MINES HEALTH CENTER | Potosi | E21 Health Care | $16.2M | 8 |
| CONVENTION & VISITORS BUREAU OF GREATER | Kansas City | — | $16.2M | 11 |
| OUR LADY OF PEACE INC | St Louis | — | $16.1M | 4 |
| COX HPS OF THE OZARKS INC | Springfield | E70Z Health Care | $16.1M | 10 |
| ASCENSION BRIGHTON CENTER FOR RECOVERY | St Louis | E22Z Health Care | $16M | 14 |
| AMANDA LUCKETT MURPHY HOPEWELL CENTER | St Louis | F30Z Mental Health & Crisis Intervention | $16M | 6 |
| Hannibal LaGrange University | Hannibal | B42Z Education | $15.9M | 5 |
| Presence Behavioral Health | St Louis | F320 Mental Health & Crisis Intervention | $15.9M | 7 |
| Wamego Hospital Association | St Louis | E20 Health Care | $15.9M | 5 |
| COLUMBIA INDEPENDENT SCHOOL INC | Columbia | B20 Education | $15.8M | 1 |
| Saint Lukes Foundation | Kansas City | E110 Health Care | $15.7M | 16 |
| KC INTERNATIONAL ACADEMY | Kansas City | B29 Education | $15.6M | 6 |
| COMMUNITY ACTION AGENCY OF | Overland | — | $15.5M | 3 |
| IBEW-124 VACATION AND HOLIDAY TRUST FUND | Kansas City | — | $15.5M | 0 |
| FOSTER CARE COALITION OF GREATER | St Louis | — | $15.4M | 2 |
| LEGAL SERVICES OF EASTERN MISSOURI INC | St Louis | I800 Crime & Legal-Related | $15.3M | 7 |
| Grundy Electric Cooperative | Trenton | — | $15.3M | 15 |
| NOVUS HEALTH INC | Saint Louis | H81 Medical Research | $15.3M | 6 |
| Tri-County Electric Cooperative | Lancaster | — | $15.3M | 17 |
| MOMENTUM ACADEMY INC | St Louis | B29 Education | $15.3M | 5 |
| South Central Missouri Community | Winona | S200 Community Improvement & Capacity Building | $15.2M | 1 |
| COUNTERPUBLIC | St Louis | A20 Arts, Culture & Humanities | $15.2M | 1 |
| KIPP KANSAS CITY | Kanas City | B24 Education | $15.2M | 1 |
| ALEXIAN VILLAGE OF MILWAUKEE INC | St Louis | P750 Human Services | $15.2M | 8 |
| Evangelical Children's Home | St Louis | P730 Human Services | $15.1M | 5 |
| WHEATON FRANCISCAN HEALTHCARE - TERRACE AT ST FRANCIS INC | St Louis | — | $15.1M | 9 |
| Sinquefield Center for Research Inc | St Louis | B11 Education | $15.1M | 1 |
| REGIONAL CULTURAL AND PERFORMING ARTS | St Louis | A260 Arts, Culture & Humanities | $15M | 3 |
| JUDEVINE INC | St Louis | G84 Diseases, Disorders & Medical Disciplines | $15M | 4 |
| TRUMAN HEARTLAND COMMUNITY FOUNDATION | Independence | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $15M | 2 |
| MISSOURI ELECTRIC COOPERATIVE | Jefferson City | — | $15M | 6 |
| CROSS TRAILS MEDICAL CENTER | Cape Girardeau | B99 Education | $14.9M | 9 |
| CEMENT MASONS AND PLASTERERS LOCAL 518 | Independence | — | $14.8M | 0 |
| ANIMAL PROTECTIVE ASSOCIATION OF | Saint Louis | D200 Animal-Related | $14.8M | 2 |
| Maranatha Village Inc | Springfield | — | $14.8M | 3 |
| BEYOND HOUSING INC | Pine Lawn | L25 Housing & Shelter | $14.8M | 3 |
| GIRL SCOUTS OF EASTERN MISSOURI INC | St Louis | Z99 Unknown | $14.7M | 9 |
| ST LOUIS LABOR HEALTHCARE NETWORK | St Louis | Y43 Mutual & Membership Benefit | $14.6M | 0 |
| INTERNATIONAL BROTHERHOOD OF ELECTRICAL | St Louis | — | $14.6M | 14 |
| MISSOURI ELECTRIC COOPERATIVES | Jefferson City | — | $14.6M | 18 |
