| Wamego Hospital Association | St Louis | E20 Health Care | $17.3M | 4 |
| ALEXIAN VILLAGE OF MILWAUKEE INC | St Louis | P750 Human Services | $17.1M | 13 |
| Operation BBQ Relief | Peculiar | P60 Human Services | $17M | 9 |
| DISABLED AMERICAN VETERANS ERNESTIN SCHUMANN-HEINK MO CHAPTER NO 2 | Kansas City | W30 Public & Societal Benefit | $16.8M | 10 |
| SERVICES BY DESIGN DBA CARING SOLUTIONS | St Louis | P70 Human Services | $16.8M | 1 |
| SOUTHEAST MISSOURI UNIVERSITY FOUNDATION | Cape Girardeau | B110 Education | $16.8M | 8 |
| Tri-County Electric Cooperative | Lancaster | — | $16.8M | 17 |
| KIPP KANSAS CITY | Kanas City | B24 Education | $16.8M | 1 |
| ST CATHERINE LABOURE MANOR INC | St Louis | — | $16.8M | 9 |
| LUTHERAN FAMILY AND CHILDREN'S SERVICES OF MISSOURI | St Louis | — | $16.6M | 6 |
| BONIFACE FOUNDATION | St Louis | E110 Health Care | $16.5M | 1 |
| Presence Behavioral Health | St Louis | F320 Mental Health & Crisis Intervention | $16.4M | 7 |
| The Baptist Home Inc | Jefferson City | P750 Human Services | $16.4M | 1 |
| UFCW UNION LOCAL 88 & EMPLOYERS HEALTH & WELFARE FUND | St Louis | Y430 Mutual & Membership Benefit | $16.3M | 0 |
| VETERANS COMMUNITY PROJECT | Kansas City | W30 Public & Societal Benefit | $16.3M | 7 |
| GREAT MINES HEALTH CENTER | Potosi | E21 Health Care | $16.2M | 8 |
| CONVENTION & VISITORS BUREAU OF GREATER KANSAS CITY | Kansas City | — | $16.2M | 11 |
| OUR LADY OF PEACE INC | St Louis | — | $16.1M | 4 |
| COX HPS OF THE OZARKS INC | Springfield | E70Z Health Care | $16.1M | 10 |
| INTERFAITH RESIDENCE D/B/A DOORWAYS | St Louis | G81Z Diseases, Disorders & Medical Disciplines | $16.1M | 3 |
| SWOPE HEALTH FOUNDATION | Kansas City | E80 Health Care | $15.8M | 2 |
| WHOLESALE & SPECIALTY INSURANCE ASSOCIATION | Kansas City | — | $15.8M | 6 |
| CORNERSTONE ASSISTED LIVING INC | St Louis | P750 Human Services | $15.8M | 11 |
| Southeast Missouri Behavioral Health Inc | Farmington | — | $15.8M | 12 |
| CENTRAL MISSOURI AREA AGENCY ON AGING | Columbia | P810 Human Services | $15.7M | 3 |
| Saint Lukes Foundation | Kansas City | E110 Health Care | $15.7M | 16 |
| KC INTERNATIONAL ACADEMY | Kansas City | B29 Education | $15.6M | 6 |
| COMMUNITY ACTION AGENCY OF ST LOUIS COUNTY INC | Overland | — | $15.5M | 3 |
| IBEW-124 VACATION AND HOLIDAY TRUST FUND | Kansas City | — | $15.5M | 0 |
| FOSTER CARE COALITION OF GREATER ST LOUIS | St Louis | — | $15.4M | 2 |
| BORGESS NURSING HOME INC | St Louis | — | $15.4M | 7 |
| ST LOUIS REGIONAL PUBLIC MEDIA INC | St Louis | A320 Arts, Culture & Humanities | $15.4M | 8 |
| Grundy Electric Cooperative | Trenton | — | $15.3M | 15 |
| NOVUS HEALTH INC | Saint Louis | H81 Medical Research | $15.3M | 6 |
| MOMENTUM ACADEMY INC | St Louis | B29 Education | $15.3M | 5 |
| South Central Missouri Community Action Agency | Winona | S200 Community Improvement & Capacity Building | $15.2M | 1 |
| COUNTERPUBLIC | St Louis | A20 Arts, Culture & Humanities | $15.2M | 1 |
| Rainbow Hospice and Palliative Care | St Louis | — | $15.1M | 8 |
| BRIGHT FUTURES FUND | Kansas City | B11 Education | $15.1M | 2 |
| Evangelical Children's Home | St Louis | P730 Human Services | $15.1M | 5 |
| WEST CENTRAL MISSOURI COMMUNITY ACTION AGENCY | Appleton City | — | $15.1M | 2 |
| REGIONAL CULTURAL AND PERFORMING ARTS DEVELOPMENT COMMISSION | St Louis | A260 Arts, Culture & Humanities | $15M | 3 |
| St John Building Corporation | St Louis | S41 Community Improvement & Capacity Building | $15M | 8 |
| JUDEVINE INC | St Louis | G84 Diseases, Disorders & Medical Disciplines | $15M | 4 |
| TRUMAN HEARTLAND COMMUNITY FOUNDATION | Independence | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $15M | 2 |
| MISSOURI ELECTRIC COOPERATIVE EMPLOYEES' CREDIT UNION | Jefferson City | — | $15M | 6 |
| CROSS TRAILS MEDICAL CENTER | Cape Girardeau | B99 Education | $14.9M | 9 |
| CEMENT MASONS AND PLASTERERS LOCAL 518 HEALTH CARE FUND | Independence | — | $14.8M | 0 |
| ANIMAL PROTECTIVE ASSOCIATION OF MISSOURI | Saint Louis | D200 Animal-Related | $14.8M | 2 |
| Maranatha Village Inc | Springfield | — | $14.8M | 3 |
