| ST MARYS WARRICK HOSPITAL INC | St Louis | E220 Health Care | $19.4M | 12 |
| ALLIANCE CREDIT UNION | Fenton | — | $19.3M | 7 |
| NATIONAL WWI MUSEUM AND MEMORIAL | Kansas City | A800 Arts, Culture & Humanities | $19.3M | 6 |
| Jewish Federation of St Louis | St Louis | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $19.2M | 7 |
| Ralls County Electric Cooperative | New London | — | $19.2M | 16 |
| NORTH EAST COMMUNTIY ACTION CORPORATION | Bowling Green | — | $19.2M | 4 |
| St Vincent Salem Hospital Inc | St Louis | — | $19M | 16 |
| Lewis County Rural Electric Cooperative Assoc | Lewistown | — | $19M | 17 |
| BEHAVIORAL HEALTH RESPONSE INC | St Louis | F20Z Mental Health & Crisis Intervention | $19M | 3 |
| DISABLED CITIZENS ALLIANCE | Viburnum | — | $18.9M | 3 |
| ASCENSION BORGESS-LEE HOSPITAL | St Louis | E220 Health Care | $18.8M | 12 |
| PARENTS AS TEACHERS NATIONAL CENTER INC | St Louis | G030 Diseases, Disorders & Medical Disciplines | $18.8M | 7 |
| THE W W SMITH CHARITABLE TRUST TUW | Saint Louis | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $18.8M | 1 |
| CLEAN FUELS ALLIANCE AMERICA | Jefferson City | — | $18.8M | 9 |
| LIFT FOR LIFE ACADEMY INC | Saint Louis | N40Z Recreation & Sports | $18.8M | 4 |
| MISSOURI ATHLETIC CLUB | St Louis | — | $18.7M | 8 |
| DOUGLAS COUNTY PUBLIC HEALTH SVCS GROUP INC | Ava | E30 Health Care | $18.3M | 11 |
| Heart Surgeons of Kansas City Inc | Kansas City | E21 Health Care | $18.3M | 11 |
| CONCORDANCE | St Louis | I31Z Crime & Legal-Related | $18.2M | 9 |
| BOILERMAKERS NAT'L APPRENTICESHIP | Kansas City | — | $18.1M | 0 |
| UNITED CEREBRAL PALSY HEARTLAND | Berkeley | G200 Diseases, Disorders & Medical Disciplines | $18.1M | 4 |
| ACADEMIE LAFAYETTE | Kansas City | P40 Human Services | $18.1M | 2 |
| EAST MISSOURI ACTION AGENCY INC | Park Hills | S800 Community Improvement & Capacity Building | $18M | 1 |
| HOPE EDUCATIONAL & RESEARCH CENTER | St Louis | B20 Education | $18M | 7 |
| Baptist Health Care Affiliates inc | St Louis | E110 Health Care | $18M | 9 |
| MIDWEST CHRISTIAN VILLAGES | St Louis | P81 Human Services | $17.9M | 26 |
| DISABLED AMERICAN VETERANS ERNESTIN | Kansas City | W30 Public & Societal Benefit | $17.9M | 11 |
| Community Health Center of Central Missouri | Jefferson City | P80 Human Services | $17.8M | 7 |
| Saint Thomas Hickman Hospital | St Louis | E20 Health Care | $17.7M | 16 |
| MBCH CHILDREN AND FAMILY MINISTRIES | Bridgeton | P70 Human Services | $17.6M | 4 |
| Mercy St Francis Hospital | Mountain View | E220 Health Care | $17.6M | 12 |
| ALTERNATIVE COMMUNITY TRAINING INC (TAX) | Columbia | J300 Employment | $17.6M | 2 |
| PREMIER CHARTER SCHOOL | St Louis | B110 Education | $17.5M | 3 |
| KAUFFMAN CENTER FOR THE PERFORMING ARTS | Kansas City | A61 Arts, Culture & Humanities | $17.5M | 6 |
| UNIVERSITY ACADEMY | Kansas City | B20 Education | $17.5M | 4 |
| The Children's Mercy Hospital Foundation | Kansas City | E110 Health Care | $17.5M | 2 |
| Rainbow Hospice and Palliative Care | St Louis | — | $17.4M | 8 |
| ST VINCENT'S FOUNDATION INC | St Louis | — | $17.3M | 9 |
| CORTEX | St Louis | S20 Community Improvement & Capacity Building | $17.2M | 8 |
| GREATER ST LOUIS INC | St Louis | S41 Community Improvement & Capacity Building | $17.1M | 7 |
| AUTOMOTIVE PETROLEUM & ALLIED INDUSTRIES | Earth City | — | $17M | 2 |
| CLARK COMMUNITY MENTAL HEALTH | Pierce City | E20Z Health Care | $17M | 9 |
| HOGAN PREPARATORY ACADEMY INC | Kansas City | B20 Education | $16.9M | 1 |
| MINISTRY HEALTH CARE INC | St Louis | — | $16.9M | 6 |
| Alexian Brothers Medical Care Group NFP | St Louis | E21 Health Care | $16.9M | 8 |
| SERVICES BY DESIGN DBA CARING SOLUTIONS | St Louis | P70 Human Services | $16.8M | 1 |
| WEST CENTRAL MISSOURI COMMUNITY | Appleton City | — | $16.7M | 2 |
| CHESS CLUB AND SCHOLASTIC CENTER | St Louis | N31 Recreation & Sports | $16.7M | 7 |
| ABILITY KC | Kansas City | — | $16.7M | 9 |
| LUTHERAN FAMILY AND CHILDREN'S SERVICES | St Louis | — | $16.6M | 6 |
