| Research Triangle Foundation of NC | Research Triangle Park | — | $16.7M | 9 |
| METROPOLITAN COMMUNITY HEALTH SERVICES INC | Washington | E20 Health Care | $16.7M | 6 |
| CHILD CARE RESOURCES INC | Charlotte | — | $16.6M | 2 |
| TRIANGLE CHARTER EDUCATION ASSOCIATION INC | Cary | B29 Education | $16.6M | 1 |
| Anuvia Prevention and Recovery Center Inc | Charlotte | — | $16.6M | 7 |
| BENNETT COLLEGE | Greensboro | B420 Education | $16.6M | 9 |
| COMMUNITY INVESTMENTS FOUNDATION | Charlotte | P117 Human Services | $16.5M | 7 |
| PPRC NURSING HOME INC | High Point | E91 Health Care | $16.5M | 2 |
| HOSPICE OF LAURENS COUNTY INC | Charlotte | P74Z Human Services | $16.5M | 10 |
| PHOENIX ACADEMY INC | High Point | B11 Education | $16.4M | 0 |
| NORTH CAROLINA VETERINARY MEDICAL FOUNDATION INC | Raleigh | B115 Education | $16.4M | 3 |
| PARTNERSHIP FOR CHILDREN OF CUMBERLAND COUNTY INC | Fayetteville | B012 Education | $16.3M | 1 |
| NORTH CAROLINA MUSEUM OF LIFE & SCIENCE INC | Durham | A560 Arts, Culture & Humanities | $16.3M | 5 |
| Lake Junaluska Assembly Inc | Lake Junaluska | X99 Religion-Related | $16.3M | 2 |
| DUKE SCHOOL | Durham | — | $16.2M | 4 |
| CORVIAN COMMUNITY SCHOOL INC | Charlotte | B29 Education | $16.2M | 3 |
| Lutheran Home at Trinity Oaks Inc | Salisbury | — | $16.2M | 7 |
| BELOVED ASHEVILLE | Asheville | L20 Housing & Shelter | $16.1M | 2 |
| CAROLINA FRIENDS SCHOOL | Durham | — | $16.1M | 2 |
| Lutheran Home - Hickory West Inc | Salisbury | — | $16M | 6 |
| NORTH CAROLINA INSURANCE GUARANTY ASSOCI | Raleigh | — | $16M | 7 |
| HOLY ANGELS SERVICES INC | Belmont | — | $16M | 5 |
| AMERICAN THROMBOSIS AND HEMOSTASIS NETWORK INC | Hickory | H99 Medical Research | $16M | 11 |
| Carolina Golf Club Inc | Charlotte | — | $16M | 3 |
| COASTAL COMMUNITY ACTION INC | Newport | — | $15.9M | 0 |
| Thomas Jefferson Classical Academy | Mooresboro | B20 Education | $15.8M | 3 |
| Yadkin Valley Economic Development District Inc | Boonville | P20 Human Services | $15.8M | 1 |
| NEW YORK UNIVERSITY SCHOOL OF MEDICINE | Charlotte | — | $15.8M | 1 |
| CAROLINA UNIVERSITY | Winstonsalem | B40 Education | $15.8M | 5 |
| Cornerstone Charter Academy A Challenge Foundation Academy Inc | Greensboro | B29 Education | $15.7M | 3 |
| UNITED WAY OF NORTH CAROLINA | Cary | T70Z Philanthropy, Voluntarism & Grantmaking Foundations | $15.7M | 1 |
| INVEST COLLEGIATE IMAGINE INC | Asheville | B29 Education | $15.7M | 1 |
| ELDERHAUS INC | Wilmington | — | $15.6M | 6 |
| Cabarrus Cooperative Christian Ministry | Concord | — | $15.5M | 1 |
| PRESBYTERIAN HOSPITAL FOUNDATION | Winston Salem | E22I Health Care | $15.5M | 11 |
| IMPACT HEALTH | Asheville | E60 Health Care | $15.5M | 9 |
| Columbus Regional Health Network | Whiteville | E30 Health Care | $15.5M | 3 |
| COMMUNITY FOUNDATION OF GREATER GREENSBORO INC | Greensboro | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $15.4M | 7 |
| STANLEY TOTAL LIVING CENTER INC | Stanley | P75Z Human Services | $15.4M | 2 |
| PI KAPPA PHI PROPERTIES INC | Charlotte | — | $15.4M | 3 |
| THE MOREHEAD-CAIN FOUNDATION | Chapel Hill | B82Z Education | $15.3M | 12 |
| God's World Publications Inc | Asheville | X830 Religion-Related | $15.3M | 10 |
| The Asha and Sajjan Agarwal Foundation | Raleigh | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $15.1M | 0 |
| CAPE FEAR COMMUNITY COLLEGE FOUNDATION INC | Wilmington | B20 Education | $15.1M | 0 |
| KINSTON COMMUNITY HEALTH CENTER INC | Kinston | E32Z Health Care | $14.9M | 10 |
| QUEEN'S GRANT COMMUNITY SCHOOL INC | Mint Hill | B24 Education | $14.8M | 0 |
| ANGEL MINISTRIES | Raleigh | X20Z Religion-Related | $14.8M | 3 |
| Brother Wolf Animal Rescue Inc | Asheville | D20 Animal-Related | $14.7M | 1 |
| UNITY CLASSICAL CHARTER SCHOOL A CHALLENGE FOUNDATION ACADEMY | Charlotte | B29 Education | $14.7M | 0 |
| BREVARD MUSIC CENTER INCORPORATED | Brevard | — | $14.7M | 5 |
