| CHILDREN'S ADVOCACY CENTERS OF NORTH CAROLINA INC | Graham | I72 Crime & Legal-Related | $12.8M | 2 |
| UNION COUNTY CHARTER EDUCATION ASSOCIATION INC | Indian Trail | B24 Education | $12.8M | 1 |
| COMMUNITY ACTION OPPORTUNITIES | Asheville | P20 Human Services | $12.8M | 4 |
| The Center for Black Health and Equity | Durham | F52 Mental Health & Crisis Intervention | $12.8M | 1 |
| SISTERS OF MERCY URGENT CARE INC | Asheville | — | $12.7M | 9 |
| STATE LEADERSHIP PROJECT | Raleigh | W70 Public & Societal Benefit | $12.7M | 0 |
| HOSPICE OF GASTON COUNTY INC | Gastonia | — | $12.6M | 8 |
| THREE RIVERS LAND TRUST INC | Salisbury | C340 Environment | $12.6M | 1 |
| THE NORTH CAROLINA LEADERSHIP CHARTER ACADEMY INC | Kernersville | B29 Education | $12.5M | 1 |
| DURHAM COMMUNITY LAND TRUSTEES INC | Durham | L200 Housing & Shelter | $12.5M | 1 |
| NORTH CAROLINA ASSOCIATION OF REALTORS INC | Greensboro | — | $12.5M | 10 |
| PURPLE HEART HOMES INC | Statesville | W30 Public & Societal Benefit | $12.5M | 4 |
| CUMBERLAND COMMUNITY FOUNDATION INC | Fayetteville | T31Z Philanthropy, Voluntarism & Grantmaking Foundations | $12.5M | 2 |
| Cape Fear Country Club Incorporated | Wilmington | — | $12.5M | 9 |
| HARBORPATH INC | Charlotte | G81 Diseases, Disorders & Medical Disciplines | $12.4M | 1 |
| BlueWest Opportunities Inc | Asheville | G84Z Diseases, Disorders & Medical Disciplines | $12.3M | 2 |
| FREEDOM HOUSE RECOVERY CENTER INC | Chapel Hill | — | $12.3M | 7 |
| GET READY GUILFORD | Greensboro | B11 Education | $12.3M | 1 |
| Phoenix Counseling Center | Gastonia | B990 Education | $12.3M | 7 |
| NATIONAL INSTITUTE OF MINORITY ECONOMIC DEVELOPMENT | Durham | — | $12.2M | 6 |
| Gaston County Family YMCA | Gastonia | — | $12.2M | 2 |
| Residential Services Inc | Chapel Hill | F33Z Mental Health & Crisis Intervention | $12.1M | 2 |
| GASTON COMMUNITY FOUNDATION | Gastonia | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $12.1M | 1 |
| GRACE LIFECARE INC | Morganton | P750 Human Services | $12.1M | 7 |
| STACKS OPEN INTERNET FOUNDATION | Cary | — | $12M | 6 |
| THE FLETCHER SCHOOL INC | Charlotte | — | $12M | 5 |
| JAARS INC | Waxhaw | S80 Community Improvement & Capacity Building | $11.9M | 3 |
| Catapult Employers Association Inc | Charlotte | — | $11.9M | 8 |
| B&D Integrated Health Services | Durham | F33 Mental Health & Crisis Intervention | $11.9M | 2 |
| WNC BRIDGE FOUNDATION | Asheville | T12 Philanthropy, Voluntarism & Grantmaking Foundations | $11.8M | 2 |
| SOUTHWESTERN CHILD DEVELOPMENT COMMISSION INC | Webster | — | $11.8M | 3 |
| SENIOR SERVICES INC | Winstonsalem | P81Z Human Services | $11.8M | 3 |
| Girl Scouts - North Carolina Coastal Pines Inc | Raleigh | O42 Youth Development | $11.7M | 7 |
| FELLOWSHIP HALL INC | Greensboro | F220 Mental Health & Crisis Intervention | $11.7M | 7 |
| FOUNDATION FOR THE CHARLOTTE JEWISH COMMUNITY | Charlotte | X123 Religion-Related | $11.7M | 2 |
| AMERICAN BOARD OF ORTHOPAEDIC SURGERY | Chapel Hill | — | $11.7M | 26 |
| COMSERV INC | Lenoir | P73Z Human Services | $11.7M | 4 |
| TRINITY ACADEMY OF RALEIGH | Raleigh | B20 Education | $11.7M | 2 |
| CRYSTAL COAST TOURNAMENT INC | Morehead City | P34J Human Services | $11.7M | 1 |
| PAVILLON INTERNATIONAL | Mill Spring | F20Z Mental Health & Crisis Intervention | $11.7M | 9 |
| Wilmington Education Organization | Wilmington | B29 Education | $11.7M | 0 |
| ST TIMOTHY'S SCHOOL | Raleigh | B24 Education | $11.7M | 4 |
| WESTERN CAROLINA UNIVERSITY FOUNDATION | Cullowhee | B43I Education | $11.7M | 0 |
| THE INDUSTRIAL COMMONS | Morganton | J20 Employment | $11.7M | 4 |
| COMMUNITY REAL PROPERTY HOLDINGS INC | Charlotte | P117 Human Services | $11.6M | 5 |
| Lutheran Retirement Center - Salisbury Inc | Salisbury | L22Z Housing & Shelter | $11.6M | 6 |
| SOCIETY FOR THE PREVENTION OF CRUELTY TO ANIMALS WAKE COUNTY INC | Raleigh | D200 Animal-Related | $11.6M | 1 |
| COMPASSION HEALTH CARE INC | Yanceyville | E32Z Health Care | $11.6M | 11 |
| CARY CHRISTIAN SCHOOL INCORPORATED | Cary | B20Z Education | $11.6M | 3 |
| THE FOUNDATION OF FIRSTHEALTH INC | Pinehurst | — | $11.6M | 4 |
