| AMERICAN ASSOCIATION FOR HOMECARE | Arlington | — | $5.4M | 11 |
| AMERICAN ORTHOTIC AND PROSTHETIC ASSOCIATION | Alexandria | — | $5.4M | 5 |
| FREEDOM VIRGINIA INC | Norfolk | W01 Public & Societal Benefit | $5.4M | 1 |
| HAKOPIAN FAMILY FOUNDATION | Great Falls | P40 Human Services | $5.4M | 0 |
| THE TITMUS FOUNDATION | Sutherland | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $5.4M | 6 |
| PITTSYLVANIA COUNTY COMMUNITY ACTION INC | Chatham | — | $5.4M | 0 |
| International Board of Lactation Consultant Examiners | Fairfax | E4XZ Health Care | $5.4M | 5 |
| GLOBAL RESILIENCE FEDERATION INC | Fairfax | S41 Community Improvement & Capacity Building | $5.4M | 6 |
| RICHMOND INSTITUTE FOR VETERANS RESEARCH | Richmond | H990 Medical Research | $5.4M | 3 |
| CENTER FOR AMERICAN IDEAS | McLean | W05 Public & Societal Benefit | $5.4M | 1 |
| WateReuse Association | Alexandria | — | $5.4M | 6 |
| GIRL SCOUT COUNCIL OF COLONIAL COAST | Chesapeake | O42Z Youth Development | $5.4M | 1 |
| PIPE LINE CONTRACTORS ASSOCIATION | Arlington | — | $5.4M | 4 |
| STONY CREEK COMMUNITY HEALTH CENTER | Stony Creek | — | $5.4M | 4 |
| CENTER FOR EARLY SUCCESS | Danville | P33 Human Services | $5.3M | 1 |
| MONTPELIER FOUNDATION | Orange | A540 Arts, Culture & Humanities | $5.3M | 3 |
| Mercy Medical Angels | Norfolk | E62Z Health Care | $5.3M | 1 |
| DEFENDING EDUCATION | Arlington | R20 Civil Rights, Social Action & Advocacy | $5.3M | 6 |
| ACADEMY CENTER OF THE ARTS INC | Lynchburg | A61 Arts, Culture & Humanities | $5.3M | 1 |
| SAMARITAN HOUSE INC | Virginia Beach | L410 Housing & Shelter | $5.3M | 1 |
| Isle of Wight County Educational Foundation Inc | Isle Of Wight | B20 Education | $5.3M | 1 |
| Richmond Association of Realtors Inc | Richmond | — | $5.3M | 7 |
| USA Rice Council | Arlington | — | $5.3M | 4 |
| American Principles Project | Arlington | R010 Civil Rights, Social Action & Advocacy | $5.3M | 5 |
| Showalter Center Inc | Blacksburg | L22Z Housing & Shelter | $5.3M | 7 |
| Teachers of English to Speakers of Other Languages Inc | Alexandria | B63C Education | $5.3M | 5 |
| ALEXANDRIA CONVENTION & VISITORS ASSOCIATION | Alexandria | — | $5.3M | 2 |
| SJOGREN'S FOUNDATION INC | Reston | G40 Diseases, Disorders & Medical Disciplines | $5.3M | 6 |
| NW WORKS INC | Winchester | J300 Employment | $5.3M | 2 |
| FAGUS FOUNDATION | Middleburg | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $5.3M | 0 |
| THE UNITED COMPANY FOUNDATION | Bristol | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $5.3M | 2 |
| Gesher School Inc | Fairfax | B24Z Education | $5.3M | 1 |
| FIRSTSPARK INC | Newport News | B21 Education | $5.3M | 1 |
| AMERICAN ANTHROPOLOGICAL ASSOCIATION | Arlington | V21C Social Science | $5.3M | 7 |
| GLOBAL WATER CHALLENGE | Arlington | C32 Environment | $5.3M | 0 |
| TYSONS CORNER CHILDRENS CENTER | McLean | P33Z Human Services | $5.3M | 4 |
| Law Enforcement Legal Defense Fund | Alexandria | — | $5.3M | 2 |
| THE VIRGINIA FOUNDATION FOR COMMUNITY COLLEGE EDUCATION INC | Richmond | — | $5.2M | 0 |
| WAKEFIELD COUNTRY DAY SCHOOL INC | Flint Hill | B200 Education | $5.2M | 2 |
| DO NO HARM | Glen Allen | M40 Public Safety, Disaster Preparedness & Relief | $5.2M | 3 |
| HOSPITAL HOSPITALITY HOUSE OF RICHMOND INC | Richmond | E86Z Health Care | $5.2M | 5 |
| KETTLER HEALTH CARE PLAN | McLean | Y43 Mutual & Membership Benefit | $5.2M | 1 |
| THE ALUMNI BOARD OF TRUSTEES OF THE UNIVERSITY OF VA ENDOWMENT FUND | Charlottesville | B110 Education | $5.2M | 2 |
| FUTURE BUSINESS LEADERS OF AMERICA INC | Reston | — | $5.2M | 2 |
| ROCKBRIDGE AREA HOSPICE INC | Lexington | P74Z Human Services | $5.2M | 1 |
| NATIONAL D-DAY MEMORIAL FOUNDATION | Bedford | N52Z Recreation & Sports | $5.2M | 1 |
| NORTHERN VIRGINIA FOOD RESCUE | Manassas | K31 Food, Agriculture & Nutrition | $5.2M | 1 |
| HIGHWAY LOSS DATA INSTITUTE | Arlington | — | $5.2M | 10 |
| Association of Independent Corrugated Converters | Alexandria | — | $5.2M | 5 |
| CENTER FOR REGIONAL ECONOMIC COMPETITIVENESS | Arlington | S30 Community Improvement & Capacity Building | $5.2M | 8 |
