| NORTH COUNTRY HEALTHCARE INC | Flagstaff | — | $63.4M | 11 |
| MARIPOSA COMMUNITY HEALTH CENTER | Nogales | E32Z Health Care | $62.7M | 13 |
| ARIZONA BEHAVIORAL HEALTH CORPORATION | Phoenix | Z99 Unknown | $61M | 5 |
| UTAH-IDAHO TEAMSTERS SECURITY FUND | Phoenix | — | $59.6M | 0 |
| LINCOLN INSTITUTE OF LAND POLICY | Phoenix | B110 Education | $55.3M | 22 |
| TMC Medical Network | Tucson | E21 Health Care | $55.1M | 5 |
| KAIZEN EDUCATION FOUNDATION | Phoenix | A12 Arts, Culture & Humanities | $53.9M | 0 |
| Intl Brotherhood of Electrical Workers | Phoenix | — | $53.3M | 0 |
| ABILITY360 INC | Phoenix | P80Z Human Services | $52.7M | 5 |
| LEMAN ACADEMY OF EXCELLENCE INC | Tucson | B20 Education | $52.3M | 8 |
| Arizona Humane Society | Phoenix | D200 Animal-Related | $52.2M | 11 |
| AMERICAN CHARTER SCHOOLS FOUNDATION | Phoenix | B122 Education | $51.8M | 1 |
| Phoenix Children's Hospital Foundation | Phoenix | E112 Health Care | $51.6M | 7 |
| LA POSADA AT PARK CENTRE INC | Green Valley | P750 Human Services | $51.2M | 12 |
| Community Hospital Association Inc | Wickenburg | E22Z Health Care | $49.8M | 12 |
| PARTNERS IN RECOVERY LLC | Mesa | F32 Mental Health & Crisis Intervention | $49.1M | 2 |
| CITY OF SCOTTSDALE MUNICIPAL PROPERTY | Scottsdale | — | $49M | 0 |
| ARIZONA LEADERSHIP FOUNDATION INC | Scottsdale | B82 Education | $49M | 3 |
| La Paz Regional Hospital | Parker | E20 Health Care | $48.9M | 10 |
| UNITED CEREBRAL PALSY OF SOUTHERN | Tucson | P80 Human Services | $48.5M | 4 |
| The Diane and Bruce Halle Foundation | Scottsdale | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $47.7M | 0 |
| EASTERSEALS BLAKE FOUNDATION | Tucson | P800 Human Services | $47.1M | 9 |
| CHILD PARENT CENTERS | Tucson | B210 Education | $46.9M | 7 |
| ARIZONA CENTER FOR NATURE CONSERVATION | Phoenix | D500 Animal-Related | $46.7M | 8 |
| CATHOLIC CHARITIES COMMUNITY SERVICES | Phoenix | P200 Human Services | $46.7M | 8 |
| UNITED FOOD BANK | Mesa | K31Z Food, Agriculture & Nutrition | $46M | 3 |
| SAN LUIS WALK-IN CLINIC INC | Somerton | E40 Health Care | $45.7M | 7 |
| CENTER FOR BIOLOGICAL DIVERSITY INC | Tucson | D20 Animal-Related | $45.7M | 11 |
| SUNSET COMMUNITY HEALTH CENTER | Yuma | E30 Health Care | $45.6M | 8 |
| COMMISSION ON ACCREDITATION OF | Tucson | E50D Health Care | $45M | 8 |
| American Conservation Experience | Flagstaff | C19 Environment | $44.7M | 8 |
| HORIZON HEALTH AND WELLNESS INC | Apache Junction | F31Z Mental Health & Crisis Intervention | $44.6M | 13 |
| Goodwill Industries of Southern AZ Inc | Tucson | — | $44.2M | 8 |
| GREATHEARTS ARIZONA | Phoenix | B022 Education | $43.7M | 7 |
| La Frontera Center Inc | Tucson | P840 Human Services | $43.5M | 9 |
| AREA AGENCY ON AGING REGION ONE INC | Phoenix | P81Z Human Services | $43.4M | 8 |
| Valley of the Sun Young Men's Christian Association | Phoenix | P270 Human Services | $43.2M | 9 |
| LITTLE COLORADO MEDICAL CENTER | Winslow | E22Z Health Care | $42.8M | 8 |
| CRITICAL PATH INSTITUTE | Tucson | H99 Medical Research | $42.6M | 15 |
| ARIZONA CENTRAL CREDIT UNION | Phoenix | — | $42.4M | 16 |
| Catholic Community Services of Southern | Tucson | — | $42.2M | 7 |
| CHILDHELP INC | Scottsdale | P300 Human Services | $41.5M | 21 |
| JEWISH FAMILY AND CHILDREN'S SERVICE | Phoenix | P30Z Human Services | $41.3M | 8 |
| CHILD CRISIS ARIZONA | Mesa | I720 Crime & Legal-Related | $41.1M | 8 |
| MUSICAL INSTRUMENT MUSEUM | Phoenix | A50 Arts, Culture & Humanities | $41.1M | 5 |
| Virginia G Piper Charitable Trust | Phoenix | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $41M | 12 |
| Legacy Traditional Schools - Nevada Inc | Chandler | B29 Education | $40.7M | 2 |
| LIFEWELL | Phoenix | — | $40.5M | 11 |
| DIABETES PREVENTION AND AID FUND | Nogales | K30Z Food, Agriculture & Nutrition | $40.4M | 1 |
| A NEW LEAF | Mesa | F20Z Mental Health & Crisis Intervention | $39.9M | 11 |
