| LOMA LINDA - INLAND EMPIRE CONSORTIUM FOR HEALTHCARE EDUCATION | San Bernardino | T99 Philanthropy, Voluntarism & Grantmaking Foundations | $89.6M | 11 |
| CALIFORNIA VIRTUAL ACADEMY AT LOS ANGELES | Simi Valley | B29 Education | $89.6M | 0 |
| THE ELI AND EDYTHE BROAD FOUNDATION | Los Angeles | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $89.1M | 1 |
| OTIS COLLEGE OF ART AND DESIGN | Los Angeles | B400 Education | $88.5M | 18 |
| IBEWNECA SOUND AND COMMUNICATIONS HEALTH AND WELFARE PLAN | San Jose | — | $88.3M | 1 |
| SECOND HARVEST FOOD BANK OF ORANGE COUNTY INC | Irvine | K31 Food, Agriculture & Nutrition | $88.3M | 7 |
| LOW INCOME INVESTMENT FUND | San Francisco | L820 Housing & Shelter | $88.3M | 11 |
| ACADEMY FOUNDATION | Beverly Hills | A310 Arts, Culture & Humanities | $88M | 14 |
| The Center for Strategic Economic Studies and Institutional Development | Los Angeles | S99 Community Improvement & Capacity Building | $88M | 3 |
| RIVIAN FOUNDATION | Irvine | C34 Environment | $87.6M | 0 |
| AIDS MCO OF FLORIDA INC | Los Angeles | G81 Diseases, Disorders & Medical Disciplines | $87.4M | 2 |
| RIVERSIDE-SAN BERNARDINO COUNTY INDIAN HEALTH INC | Grand Terrace | E300 Health Care | $87.2M | 38 |
| BM-A INSTITUTE | Palo Alto | B40 Education | $87.1M | 0 |
| Northern Valley Indian Health Inc | Willows | E320 Health Care | $87M | 14 |
| AVID CENTER | San Diego | B99Z Education | $86.9M | 15 |
| AZTEC SHOPS LTD | San Diego | B113 Education | $86.8M | 13 |
| COMMUNITY CLINICS HEALTH NETWORK DBA HEALTH QUALITY PARTNERS | San Diego | E120 Health Care | $86.7M | 11 |
| OLE HEALTH | Napa | E32Z Health Care | $86.6M | 13 |
| Monterey Bay Aquarium Research Institute | Moss Landing | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $86.3M | 15 |
| IBEW LOCAL 332 HEALTH WELFARE PLAN | San Jose | — | $86.2M | 0 |
| SOKA UNIVERSITY OF AMERICA | Aliso Viejo | B43 Education | $86.2M | 15 |
| EDEN HOUSING INC | Hayward | L210 Housing & Shelter | $86M | 11 |
| COAST CENTRAL CREDIT UNION | Eureka | — | $85.3M | 7 |
| THE CALIFORNIA WELLNESS FOUNDATION | Los Angeles | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $85.3M | 17 |
| CASA COLINA INC | Pomona | F020 Mental Health & Crisis Intervention | $85.2M | 11 |
| The Master's University and Seminary | Santa Clarita | B42 Education | $85.1M | 15 |
| Claremont Graduate University | Claremont | B430 Education | $85.1M | 12 |
| SANTA ROSA COMMUNITY HEALTH CENTERS | Santa Rosa | E32Z Health Care | $85M | 10 |
| WU YEE CHILDREN'S SERVICES | San Francisco | — | $85M | 7 |
| URBAN ALCHEMY | San Francisco | S99 Community Improvement & Capacity Building | $84.9M | 12 |
| TAIPEI AMERICAN SCHOOL FOUNDATION | Los Angeles | B20I Education | $84.9M | 24 |
| MARK TWAIN MEDICAL CENTER | San Francisco | E22Z Health Care | $84.8M | 17 |
| Elica Health Centers | Sacramento | E32 Health Care | $84.7M | 14 |
| THE ENERGY FOUNDATION | San Francisco | — | $84.5M | 14 |
| MAGNOLIA EDUCATIONAL AND RESEARCH FOUNDATION | Los Angeles | B90 Education | $84.4M | 8 |
| SACRAMENTO FOOD BANK & FAMILY SERVICES | Sacramento | — | $84.2M | 7 |
| Young Men's Christian Association of the East Bay | Berkeley | P270 Human Services | $83.8M | 8 |
| BRAILLE INSTITUTE OF AMERICA INC | Los Angeles | P860 Human Services | $83.6M | 11 |
| Adventist Health Mendocino Coast | Fort Bragg | — | $83.4M | 21 |
| OPEN PHILANTHROPY ACTION FUND | Palo Alto | S01 Community Improvement & Capacity Building | $83.2M | 0 |
| Motion Picture Association Inc | Sherman Oaks | — | $83.2M | 14 |
| TURNING POINT COMMUNITY PROGRAMS | Rancho Cordova | P820 Human Services | $83.2M | 12 |
| BRENTWOOD SCHOOL | Los Angeles | B200 Education | $83.1M | 9 |
| Oaks Christian School | Westlake Village | B250 Education | $82.8M | 10 |
| Central Valley Community Foundation A Corporation | Fresno | T50 Philanthropy, Voluntarism & Grantmaking Foundations | $82.7M | 8 |
| CocoKids Inc | Concord | P30L Human Services | $82.5M | 5 |
| Western Health Resources | Roseville | — | $82.4M | 15 |
| FEEDING SAN DIEGO | San Diego | K30 Food, Agriculture & Nutrition | $82.3M | 7 |
| INTERNATIONAL FINANCIAL REPORTING STANDARDS FOUNDATION | San Francisco | — | $82.2M | 36 |
| BRIGHT STAR SCHOOLS | Los Angeles | B29 Education | $81.5M | 10 |
