| PARK TUDOR FOUNDATION INC | Indianapolis | B200 Education | $33.5M | 10 |
| THE ARC OF NORTHEAST INDIANA INC | Fort Wayne | P820 Human Services | $33.1M | 10 |
| JASPER COUNTY RURAL ELECTRIC MEMBERSHIP | Rensselaer | — | $32.9M | 13 |
| REAL SERVICES INC | South Bend | P600 Human Services | $32.8M | 2 |
| HENRY COUNTY RURAL ELECTRIC MEMBERSHIP | New Castle | — | $32.6M | 17 |
| 16 TECH COMMUNITY CORPORATION | Indianapolis | S30 Community Improvement & Capacity Building | $32.5M | 10 |
| GOOD SAMARITAN HOSPITAL PHYSICIAN SERVICES INC | Vincennes | E60 Health Care | $32.5M | 5 |
| CHOICES COORDINATED CARE SOLUTIONS INC | Indianapolis | P300 Human Services | $32.3M | 7 |
| METROPOLITAN YOUNG MEN'S CHRISTIAN ASSOCIATION OF GREATER FORT WAYNE | Fort Wayne | P270 Human Services | $32.3M | 4 |
| WESTMINSTER VILLAGE NORTH INC | Indianapolis | — | $32.2M | 7 |
| COMMUNITY ACTION OF NORTHEAST INDIANA | Fort Wayne | S21 Community Improvement & Capacity Building | $32M | 6 |
| NORTHWEST INDIANA LIGHTHOUSE CHARTER | Gary | B90 Education | $31.9M | 6 |
| Indiana University Health Frankfort Inc | Indianapolis | E20 Health Care | $31.9M | 27 |
| ALPHA CHI OMEGA FRATERNITY INC | Indianapolis | — | $31.6M | 0 |
| Richard M Fairbanks Foundation Inc | Indianapolis | — | $31.3M | 4 |
| STEUBEN COUNTY RURAL ELECTRIC | Angola | W80 Public & Societal Benefit | $31.3M | 15 |
| TRI-STATE FOOD BANK | Evansville | — | $31.1M | 1 |
| HANCOCK PHYSICIAN NETWORK LLC | Greenfield | — | $30.9M | 10 |
| PARAMOUNT SCHOOLS OF EXCELLENCE | Indianapolis | B29 Education | $30.9M | 5 |
| The Villages of Indiana Inc | Bloomington | P700 Human Services | $30.3M | 8 |
| ELI LILLY AND COMPANY FOUNDATION | Indianapolis | — | $30.2M | 0 |
| PARKE COUNTY RURAL ELECTRIC MEMBERSHIP | Rockville | — | $30M | 13 |
| TECH CREDIT UNION | Crown Point | W61 Public & Societal Benefit | $29.8M | 21 |
| WESTMINSTER VILLAGE WEST LAFAYETTE INC | West Lafayette | P750 Human Services | $29.7M | 5 |
| Community Stroke and Rehabilitation Center Inc | Munster | E24 Health Care | $29.6M | 15 |
| CICP FOUNDATION INC | Indianapolis | S11 Community Improvement & Capacity Building | $29.6M | 2 |
| LAKE COUNTY INDIANA NECA-IBEW | Merrillville | — | $29.1M | 2 |
| Community Village Inc | Munster | P750 Human Services | $29M | 7 |
| Christel House Academy Inc | Indianapolis | B40 Education | $28.8M | 7 |
| L I U N A STATE OF INDIANA DISTRICT | Terre Haute | — | $28.8M | 13 |
| THE VOICE OF GOD RECORDINGS INC | Jeffersonville | X800 Religion-Related | $28.8M | 2 |
| National Security Technology Accelerator | Crane | M02 Public Safety, Disaster Preparedness & Relief | $28.7M | 3 |
| COMMUNITY MENTAL HEALTH CENTER INC | Lawrenceburg | F31Z Mental Health & Crisis Intervention | $28.6M | 8 |
| DEAN & BARBARA WHITE | Merrillville | T20Z Philanthropy, Voluntarism & Grantmaking Foundations | $28.4M | 0 |
| KIPP INDIANAPOLIS INC | Indianapolis | B29 Education | $28.3M | 1 |
| KAPPA ALPHA THETA FRATERNITY HOUSING | Indianapolis | B83 Education | $28.1M | 3 |
| WHEELER MISSION MINISTRIES INC | Indianapolis | P20 Human Services | $28.1M | 6 |
| EUGENE & MARILYN GLICK FOUNDATION | Indianapolis | — | $28M | 0 |
| CUMMINS BEHAVIORAL HEALTH SYSTEMS INC | Avon | F30Z Mental Health & Crisis Intervention | $28M | 8 |
| Community Hospital of Bremen Inc | Bremen | E22Z Health Care | $28M | 12 |
| ORANGE COUNTY RURAL ELECTRIC MEMBERSHIP | Orleans | — | $27.9M | 14 |
| Conner Prairie Foundation Inc | Fishers | A11 Arts, Culture & Humanities | $27.6M | 0 |
| WHITE'S RESIDENTIAL & FAMILY SERVICES INC | Wabash | P300 Human Services | $27.3M | 4 |
| THE PATRICIA SCHAEFER FOUNDATION TR | Fort Wayne | — | $27.3M | 2 |
| INDIANAPOLIS JEWISH HOME INC | Indianapolis | E91Z Health Care | $27.2M | 8 |
| HARRISON COUNTY COMMUNITY FOUNDATION | Corydon | T12 Philanthropy, Voluntarism & Grantmaking Foundations | $27M | 2 |
| REC Holding Building Corp | Rushville | S99 Community Improvement & Capacity Building | $26.9M | 0 |
| SOUTHEASTERN INDIANA SCHOOL INSURANCE TR | Rising Sun | Y43 Mutual & Membership Benefit | $26.9M | 0 |
| FOOD BANK OF NORTHERN INDIANA INC | South Bend | K310 Food, Agriculture & Nutrition | $26.7M | 2 |
| NOBLE COUNTY RURAL ELECTRIC MEMBERSHIP CORP | Albion | — | $26.6M | 16 |
