| Future Farmers of America | Indianapolis | O52Z Youth Development | $36.1M | 9 |
| WHITEWATER VALLEY RURAL ELECTRIC MEMBERSHIP CORPORATION | Liberty | — | $36.1M | 16 |
| Retirement Living Inc | Indianapolis | P750 Human Services | $36M | 20 |
| NORTH CENTRAL INDIANA SCHOOL INSURANCE CONSORTIUM TRUST | Muncie | Y43 Mutual & Membership Benefit | $35.9M | 0 |
| Logan Community Resources Inc | South Bend | — | $35.6M | 4 |
| SAINT MARY-OF-THE-WOODS COLLEGE | St Mary Of The Woods | B42Z Education | $35.4M | 9 |
| FOUR COUNTY COMPREHENSIVE MENTAL HEALTH CENTER INC | Rochester | F30 Mental Health & Crisis Intervention | $35.3M | 12 |
| USA Track & Field Inc | Indianapolis | N700 Recreation & Sports | $35M | 15 |
| Mission Pre-Born Inc | Indianapolis | P20 Human Services | $34.7M | 7 |
| Lifeline Youth & Family Services Inc | Fort Wayne | P20 Human Services | $34.6M | 6 |
| COMMUNITY FOUNDATION OF GREATER FORT WAYNE INC | Fort Wayne | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $33.8M | 3 |
| WESTMINSTER VILLAGE GREENWOOD INC | Greenwood | P750 Human Services | $33.8M | 5 |
| Community Stroke and Rehabilitation Center Inc | Munster | E24 Health Care | $33.6M | 15 |
| PARK TUDOR FOUNDATION INC | Indianapolis | B200 Education | $33.5M | 10 |
| THE ARC OF NORTHEAST INDIANA INC | Fort Wayne | P820 Human Services | $33.1M | 10 |
| Christel House Academy Inc | Indianapolis | B40 Education | $32.9M | 8 |
| NINETWELVE INSTITUTE INC | Zionsville | U02 Science & Technology | $32.8M | 0 |
| HENRY COUNTY RURAL ELECTRIC MEMBERSHIP CORPORATION | New Castle | — | $32.6M | 17 |
| 16 TECH COMMUNITY CORPORATION | Indianapolis | S30 Community Improvement & Capacity Building | $32.5M | 10 |
| GOOD SAMARITAN HOSPITAL PHYSICIAN SERVICES INC | Vincennes | E60 Health Care | $32.5M | 5 |
| METROPOLITAN YOUNG MEN'S CHRISTIAN ASSOCIATION OF GREATER FORT WAYNE | Fort Wayne | P270 Human Services | $32.3M | 4 |
| COMMUNITY ACTION OF NORTHEAST INDIANA INC | Fort Wayne | S21 Community Improvement & Capacity Building | $32M | 6 |
| Indiana University Health Frankfort Inc | Indianapolis | E20 Health Care | $31.9M | 27 |
| ALPHA CHI OMEGA FRATERNITY INC SUBORDINATE GROUP RETURN | Indianapolis | — | $31.6M | 0 |
| Richard M Fairbanks Foundation Inc | Indianapolis | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $31.3M | 4 |
| STEUBEN COUNTY RURAL ELECTRIC MEMBERSHIP CORPORATION | Angola | W80 Public & Societal Benefit | $31.3M | 15 |
| NORTHWEST INDIANA LIGHTHOUSE CHARTER SCHOOLS | Gary | B90 Education | $31.3M | 6 |
| Good Samaritan Family Health Center Inc | Vincennes | E22 Health Care | $31.2M | 3 |
| TRI-STATE FOOD BANK | Evansville | — | $31.1M | 1 |
| PARAMOUNT SCHOOLS OF EXCELLENCE | Indianapolis | B29 Education | $30.9M | 5 |
| LIUNA State of Indiana District Council | Terre Haute | — | $30.6M | 11 |
| Aspire Indiana Health Inc | Noblesville | E20 Health Care | $30.6M | 20 |
| KAPPA ALPHA THETA FRATERNITY HOUSING CORPORATION | Indianapolis | B83 Education | $30.5M | 7 |
| HOLY CROSS COLLEGE INC | Notre Dame | B41Z Education | $30.3M | 7 |
| The Villages of Indiana Inc | Bloomington | P700 Human Services | $30.3M | 8 |
| CAREER ACADEMY OF SOUTH BEND INC | South Bend | B29 Education | $30M | 3 |
| REAL SERVICES INC | South Bend | P600 Human Services | $30M | 2 |
| PARKE COUNTY RURAL ELECTRIC MEMBERSHIP CORPORATION | Rockville | — | $30M | 13 |
| NEW HOPE OF INDIANA INC | Indianapolis | — | $29.9M | 7 |
| TECH CREDIT UNION | Crown Point | W61 Public & Societal Benefit | $29.8M | 21 |
| WESTMINSTER VILLAGE WEST LAFAYETTE INC | West Lafayette | P750 Human Services | $29.7M | 5 |
| CICP FOUNDATION INC | Indianapolis | S11 Community Improvement & Capacity Building | $29.6M | 2 |
| Community Village Inc | Munster | P750 Human Services | $29.5M | 7 |
| COMMUNITY MENTAL HEALTH CENTER INC | Lawrenceburg | F31Z Mental Health & Crisis Intervention | $29.2M | 8 |
| LAKE COUNTY INDIANA NECA-IBEW HEALTH AND BENEFIT PLAN | Merrillville | — | $29.1M | 2 |
| CHRISTEL HOUSE INTERNATIONAL INC | Indianapolis | Q30 International, Foreign Affairs & National Security | $28.8M | 8 |
| SOUTHEASTERN INDIANA SCHOOL INSURANCE TR | Carmel | Y43 Mutual & Membership Benefit | $28.5M | 0 |
| DEAN & BARBARA WHITE FAMILY FOUNDATION INC | Merrillville | T20Z Philanthropy, Voluntarism & Grantmaking Foundations | $28.4M | 0 |
| KIPP INDIANAPOLIS INC | Indianapolis | B29 Education | $28.3M | 1 |
| EUGENE & MARILYN GLICK FOUNDATION | Indianapolis | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $28M | 0 |
