| EASTER SEALS MIDWEST | Saint Louis | — | $105.5M | 11 |
| Advocates For a Healthy Community Inc | Springfield | E30Z Health Care | $104.2M | 18 |
| Mercy Hospital Lebanon | Lebanon | E22Z Health Care | $102.9M | 12 |
| CENTRAL INDIANA HEALTH SYSTEM CARDIAC SERVICES INC | St Louis | — | $102.7M | 9 |
| ASCENSION VIA CHRISTI HOSPITAL MANHATTAN INC | St Louis | E220 Health Care | $102.7M | 12 |
| The Missouri Foundation for Health | St Louis | E70 Health Care | $102.4M | 9 |
| ST LOUIS AREA FOOD BANK INC | Bridgeton | — | $99M | 3 |
| Saint Thomas Regional Hospitals | St Louis | — | $98.8M | 19 |
| ASCENSION MEDICAL GROUP PROMED | St Louis | E31Z Health Care | $98.5M | 23 |
| ST LOUIS MUNICIPAL FINANCE CORPORATION | Saint Louis | W190 Public & Societal Benefit | $95.6M | 0 |
| Veterans of Foreign Wars of The United States | Kansas City | — | $94.1M | 31 |
| PLUMBERS' & PIPEFITTERS' WELFARE | Earth City | — | $93.4M | 13 |
| ARC OF THE OZARKS | Springfield | — | $93.2M | 7 |
| ASCENSION VIA CHRISTI HOSPITAL PITTSBURG INC | St Louis | E220 Health Care | $93.1M | 14 |
| Mosaic Medical Center Maryville | Saint Joseph | E22 Health Care | $91.7M | 15 |
| ST LOUIS COMMUNITY FOUNDATION INC | St Louis | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $90.3M | 8 |
| NATIONAL INSURANCE PRODUCER REGISTRY | Kansas City | — | $89.8M | 12 |
| ST LUKE'S MEDICAL GROUP | Chesterfield | — | $89.4M | 10 |
| Drury University | Springfield | B420 Education | $89.4M | 15 |
| ST MARYS MEDICAL GROUP LLC | St Louis | E31 Health Care | $86.6M | 21 |
| SWOPE HEALTH SERVICES | Kansas City | E300 Health Care | $85.6M | 11 |
| The Principia Corporation | St Louis | B200 Education | $85.5M | 18 |
| St John Providence | St Louis | E210 Health Care | $85.4M | 16 |
| Alexian Brothers Behavioral Health Hospital | St Louis | — | $85.2M | 13 |
| PARK UNIVERSITY | Parkville | B430 Education | $84.5M | 21 |
| ST LUKE'S DES PERES EPISCOPAL- | Chesterfield | E22 Health Care | $84.3M | 9 |
| OSBA EMPLOYEE BENEFITS TRUST | Bolivar | Y44 Mutual & Membership Benefit | $84M | 12 |
| LACLEDE ELECTRIC COOPERATIVE | Lebanon | — | $82.6M | 18 |
| SOUTHWEST ELECTRIC COOPERATIVE | Bolivar | — | $81.7M | 15 |
| UNITED WAY OF GREATER ST LOUIS INC | Saint Louis | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $81.4M | 10 |
| GATEWAY REGION YOUNG MEN'S | Saint Louis | P270 Human Services | $81.3M | 10 |
| Ozark Electric Cooperative Inc | Mount Vernon | — | $80.4M | 19 |
| UNITED STATES SOYBEAN EXPORT COUNCIL | Chesterfield | S40 Community Improvement & Capacity Building | $80.4M | 18 |
| Rediscover | Lees Summit | — | $79.1M | 13 |
| Alexian Brothers Ambulatory Group | St Louis | E30 Health Care | $78.4M | 8 |
| BERRY FOUNDATION | Kansas City | B60 Education | $77.7M | 13 |
| JOHN KNOX VILLAGE | Lees Summit | P750 Human Services | $77M | 12 |
| St Vincent Fishers Hospital Inc | St Louis | E22 Health Care | $76.8M | 17 |
| Platte-Clay Electric Cooperative Inc | Kearney | — | $75.8M | 15 |
| AMEREN HEALTH AND WELFARE TRUST | Saint Louis | — | $75.4M | 1 |
| BOARD OF TRUSTEES OF IBEW LOCAL 1 | St Louis | — | $75.3M | 0 |
| MISSOURI BOTANICAL GARDEN BOARD OF | St Louis | C410 Environment | $75.3M | 13 |
| CITIZENS MEMORIAL HEALTH CARE FOUNDATION | Bolivar | E91Z Health Care | $75.2M | 12 |
| TEAMSTERS & EMPLOYERS WELFARE TRUST | Earth City | — | $75.1M | 0 |
| SetonUT Austin Dell Medical School University Physicians Group | St Louis | E30 Health Care | $74.9M | 8 |
| THE RANKEN-JORDAN HOME FOR CONVALESCENT CRIPPLED CHILDREN | Maryland Heights | E91Z Health Care | $74.5M | 9 |
| International Academy of Science | Kansas City | — | $73.9M | 3 |
| Ascension Medical Group Michigan | St Louis | E32 Health Care | $73.4M | 24 |
| Boone Electric Cooperative | Columbia | — | $72.7M | 20 |
| Columbia College | Columbia | B430 Education | $72M | 14 |
