| Catholic Charities of Southern Nevada | Las Vegas | P200 Human Services | $52.5M | 7 |
| PANDA CARES FOUNDATION INC | Las Vegas | B90 Education | $51.7M | 0 |
| THE GEORGE W GILLEMOT FOUNDATION | Reno | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $51M | 0 |
| WELLS RURAL ELECTRIC COMPANY | Wells | — | $50.2M | 23 |
| ALEXANDER DAWSON FOUNDATION | Las Vegas | B200 Education | $49.5M | 11 |
| LAS VEGAS SUPER BOWL HOST COMMITTEE INC | Las Vegas | — | $47.6M | 3 |
| GREAT BASIN INSTITUTE | Reno | C60 Environment | $45.9M | 1 |
| Tahoe Community Foundation | Incline Village | B120 Education | $44.2M | 2 |
| BIT HOLDINGS THREE INC | Las Vegas | — | $43.3M | 0 |
| COMMUNITY HEALTH ALLIANCE | Reno | — | $43M | 7 |
| TEAMSTERS SECURITY FUND FOR SOUTHERN NEV | Las Vegas | — | $42.9M | 1 |
| NEVADA COMMUNITY FOUNDATION INC | Las Vegas | T31Z Philanthropy, Voluntarism & Grantmaking Foundations | $42.8M | 2 |
| MT WHEELER POWER INC | Ely | — | $42.7M | 18 |
| Renown Transitional Care Services | Reno | E400 Health Care | $42.4M | 3 |
| BPS FOUNDATION | Las Vegas | — | $41.3M | 0 |
| LEGAL AID CENTER OF SOUTHERN NEVADA | Las Vegas | R20 Civil Rights, Social Action & Advocacy | $39.6M | 7 |
| BOULDER DAM CREDIT UNION | Boulder City | — | $38.8M | 8 |
| Community Foundation of Northern Nevada | Reno | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $38.4M | 4 |
| NEVADA AFFORDABLE HOUSING ASSISTANCE CORPORATION | Las Vegas | L20 Housing & Shelter | $37.9M | 1 |
| RITE OF PASSAGE ADOLESCENT TREATMENT CENTERS AND S | Minden | — | $37M | 6 |
| The Smith Center for the Performing Arts | Las Vegas | A61 Arts, Culture & Humanities | $37M | 11 |
| OPPORTUNITY VILLAGE | Las Vegas | J330 Employment | $36.9M | 10 |
| LAS VEGAS EVENTS INC | Las Vegas | — | $36.6M | 8 |
| UNITE HERE LOCAL UNION 226 CULINARY WORKERS UNION LOCAL 226 | Las Vegas | — | $35M | 19 |
| Boulder City Hospital Inc | Boulder City | E220 Health Care | $33.2M | 9 |
| SCHOOL ADMINISTRATOR'S WELFARE TRUST | Las Vegas | — | $32.7M | 0 |
| Nathan Adelson Hospice Inc | Las Vegas | P74 Human Services | $32.3M | 7 |
| ST ROSE DOMINICAN HEALTH FOUNDATION | Henderson | E99 Health Care | $32.2M | 7 |
| CONSTRUCTION INDUSTRY AND LABORERS HEALTH AND WELFARE PLAN | Las Vegas | — | $30.7M | 2 |
| The Meadows School | Las Vegas | B200 Education | $30.7M | 6 |
| THE BOYD FAMILY FOUNDATION C/O WILLIAM S BOYD | Las Vegas | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $29.4M | 7 |
| HELP OF SOUTHERN NEVADA | Las Vegas | P200 Human Services | $28.8M | 5 |
| VOTE YES ON 3 | Las Vegas | — | $28.8M | 1 |
| WVC | Las Vegas | D024 Animal-Related | $28.4M | 30 |
| SAGEBRUSH HEALTH SERVICES | Las Vegas | P20 Human Services | $27.3M | 1 |
| SIERRA MEDICAL SERVICES ALLIANCE | Reno | E62 Health Care | $27M | 8 |
| BOYS AND GIRLS CLUB OF TRUCKEE MEADOWS | Reno | O23I Youth Development | $26.8M | 7 |
| OPPORTUNITY VILLAGE FOUNDATION | Las Vegas | T70Z Philanthropy, Voluntarism & Grantmaking Foundations | $26.7M | 3 |
| THE VILLAGE SOUTH INC | Las Vegas | F320 Mental Health & Crisis Intervention | $26.4M | 5 |
| NEVADA CHARTER ACADEMIES | Las Vegas | B29 Education | $26.3M | 2 |
| UNIVERSITY STUDIES ABROAD CONSORTIUM | Reno | B99 Education | $25.1M | 4 |
| SPORTS LEADERSHIP AND MANAGEMENT ACADEMY OF NEVADA | Las Vegas | B29 Education | $24.5M | 2 |
| HEMOSTASIS AND THROMBOSIS CENTER OF NEVADA | Las Vegas | G80 Diseases, Disorders & Medical Disciplines | $24.1M | 8 |
| LAS VEGAS CLARK COUNTY LIBRARY DISTRICT FOUNDATION | Las Vegas | B117 Education | $24M | 0 |
| NEVADA VIRTUAL CHARTER SCHOOL | Las Vegas | B29 Education | $23.7M | 2 |
| WESTCARE FOUNDATION INC | Las Vegas | P43 Human Services | $23.5M | 5 |
| DR MIRIAM AND SHELDON G ADELSON EDUCATIONAL INSTITUTE | Las Vegas | — | $23.3M | 8 |
| THE NICHOLAS & DOROTHY CUMMINGS FOUNDATION | Reno | B82Z Education | $21.6M | 1 |
| UBC NATIONAL JOB CORPS TRAINING FUND INC | Las Vegas | J22 Employment | $21.5M | 6 |
| GAY & LESBIAN COMMUNITY CENTER OF SOUTHERN NEVADA | Las Vegas | P99Z Human Services | $21M | 8 |
