| BUCKNER RETIREMENT SERVICES INC | Dallas | L220 Housing & Shelter | $72M | 14 |
| THE 1877 JOURNEY | Little Elm | L20 Housing & Shelter | $71.6M | 1 |
| DELTA DELTA DELTA COLLEGIATE CHAPTERS | Dallas | — | $71.2M | 0 |
| WORKSOURCE - GREATER AUSTIN AREA DBA WORKFORCE SOLUTIONS - CAPITAL | Austin | J200 Employment | $71.1M | 6 |
| North Texas Higher Education Authority Inc | Arlington | B80Z Education | $71M | 0 |
| TAYLOR ELECTRIC COOPERATIVE INC | Merkel | — | $70.7M | 17 |
| REMINGTON COLLEGE | Dallas | B42 Education | $70.5M | 8 |
| WE ARE BLOOD | Austin | E61Z Health Care | $70.4M | 11 |
| HEART OF TEXAS COMMUNITY HEALTH CENTER INC | Waco | E22 Health Care | $70.1M | 0 |
| THE GEORGE FOUNDATION | Richmond | — | $70.1M | 6 |
| AVOCADOS FROM MEXICO | Irving | S46 Community Improvement & Capacity Building | $69.5M | 5 |
| REGIONAL EAST TEXAS FOOD BANK | Tyler | — | $69M | 7 |
| FIVEPOINT CREDIT UNION | Nederland | — | $68.9M | 19 |
| HEART OF TEXAS ELECTRIC COOPERATIVE INC | McGregor | Y22 Mutual & Membership Benefit | $68.7M | 16 |
| THE UNIVERSITY OF TEXAS FOUNDATION INC | Austin | — | $68.5M | 1 |
| Create Healthy Management | Fredericksburg | E220 Health Care | $68.4M | 7 |
| ALLIANCE TO END PLASTIC WASTE INC | Austin | C01 Environment | $68.3M | 12 |
| FORT WORTH COMMUNITY CREDIT UNION | Bedford | — | $68.3M | 23 |
| TESSITURA NETWORK INC | Dallas | — | $67.9M | 10 |
| CATHOLIC CHARITIES OF DALLAS INC | Dallas | — | $67.6M | 10 |
| FirstDay Foundation | San Antonio | P30 Human Services | $67.5M | 12 |
| COMMUNITY RESOURCE CREDIT UNION | Baytown | — | $67.4M | 11 |
| BASIS TEXAS CHARTER SCHOOLS INC | San Antonio | B29 Education | $67.3M | 2 |
| TEXAS BAY CREDIT UNION | Houston | — | $67.2M | 17 |
| AVANCE INC | San Antonio | S20Z Community Improvement & Capacity Building | $67.1M | 13 |
| Baylor Health Care System | Dallas | E210 Health Care | $67M | 4 |
| FEDERATION OF STATE MEDICAL BOARDS OF THE UNITED STATES INC | Euless | G05 Diseases, Disorders & Medical Disciplines | $67M | 27 |
| The Awty International School | Houston | — | $66.8M | 11 |
| AMERICAN QUARTER HORSE ASSOCIATION | Amarillo | — | $66.6M | 13 |
| LUBBOCK CHRISTIAN UNIVERSITY | Lubbock | B420 Education | $66.5M | 8 |
| Cherokee County Electric Cooperative Association | Rusk | — | $66.5M | 14 |
| Community Action Corporation of South Texas | Alice | P20Z Human Services | $66.4M | 9 |
| SOUTH PLAINS COMMUNITY ACTION ASSOC | Levelland | P200 Human Services | $66.4M | 5 |
| Sunny Glen Children's Home Inc | San Benito | P70Z Human Services | $66.4M | 6 |
| HIGHLAND SPRINGS INC | Dallas | L22 Housing & Shelter | $66.3M | 7 |
| THE MENNINGER CLINIC | Houston | E300 Health Care | $66.3M | 11 |
| NAVARRO COUNTY ELECTRIC COOPERATIVE INC | Corsicana | — | $65.6M | 19 |
| TRINITY CHRISTIAN CENTER OF SANTA ANA | Fort Worth | X200 Religion-Related | $65.5M | 10 |
| TEXAS LUTHERAN UNIVERSITY | Seguin | — | $65M | 14 |
| The Philecology Foundation | Fort Worth | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $64.3M | 0 |
| RITA BLANCA ELECTRIC COOPERATIVE INC | Dalhart | — | $64M | 18 |
| TRANSPORT WORKERS MTA HEALTH & WELF | Houston | — | $63.9M | 0 |
| WARREN CHARITABLE FOUNDATION | Midland | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $63.8M | 0 |
| SAN ANTONIO ZOOLOGICAL SOCIETY | San Antonio | D500 Animal-Related | $63.8M | 10 |
| Rusk County Electric Cooperative Inc | Henderson | — | $63.3M | 14 |
| Hillcrest Physician Services | Dallas | E320 Health Care | $63.2M | 18 |
| CIRCUIT EVENTS LOCAL ORGANIZING COMMITTEE | Austin | S40 Community Improvement & Capacity Building | $62.9M | 0 |
| JASPER NEWTON ELECTRIC COOPERATIVE INC | Kirbyville | — | $62.7M | 17 |
| METHODIST CHILDREN'S HOME | Waco | P730 Human Services | $62.3M | 10 |
| MOODY GARDENS INC | Galveston | — | $62.2M | 7 |
