| Saint Francis Hospital Inc | Tulsa | E220 Health Care | $1.5B | 11 |
| INTEGRIS BAPTIST MEDICAL CENTER INC | Oklahoma City | E220 Health Care | $1.2B | 14 |
| George Kaiser Family Foundation | Tulsa | T110 Philanthropy, Voluntarism & Grantmaking Foundations | $736.2M | 8 |
| MERCY HOSPITAL OKLAHOMA CITY | Oklahoma City | E220 Health Care | $724.7M | 19 |
| COMMUNITYCARE GOVERNMENT PROGRAMS INC | Tulsa | — | $475.4M | 7 |
| INTEGRIS HEALTH INC | Oklahoma City | E210 Health Care | $437.6M | 33 |
| FEED THE CHILDREN INC | Oklahoma City | Q330 International, Foreign Affairs & National Security | $408.9M | 12 |
| TULSA COMMUNITY FOUNDATION | Tulsa | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $329.5M | 7 |
| INTEGRIS SO OKLAHOMA CITY HOSPCORP | Oklahoma City | E220 Health Care | $303.2M | 15 |
| INTEGRIS RURAL HEALTH INC | Oklahoma City | E200 Health Care | $303.1M | 15 |
| UNIVERSITY OF TULSA | Tulsa | B42 Education | $301.8M | 14 |
| OKLAHOMA STATE UNIVERSITY FOUNDATION | Stillwater | B110 Education | $281.5M | 11 |
| DELTA DENTAL PLAN OF OKLAHOMA | Oklahoma City | — | $281.4M | 32 |
| INTEGRIS AMBULATORY CARE CORP | Oklahoma City | E320 Health Care | $265.8M | 12 |
| UNIVERSITY OF OKLAHOMA FOUNDATION INC | Norman | B110 Education | $243.4M | 12 |
| COMMUNITY STRATEGIES INC | Oklahoma City | W19 Public & Societal Benefit | $240.2M | 5 |
| Warren Clinic Inc | Tulsa | E32Z Health Care | $231.5M | 10 |
| Saint Francis Hospital South LLC | Tulsa | E20 Health Care | $214.2M | 10 |
| Saint Francis Hospital Muskogee Inc | Tulsa | E20 Health Care | $209.7M | 10 |
| Duncan Regional Hospital Inc | Duncan | E220 Health Care | $196.4M | 14 |
| ORAL ROBERTS UNIVERSITY | Tulsa | B430 Education | $192.9M | 10 |
| Grand Lake Mental Health Center Inc | Nowata | F30Z Mental Health & Crisis Intervention | $190.9M | 24 |
| MERCY CLINIC OKLAHOMA COMMUNITIESINC | Oklahoma City | E30 Health Care | $189.3M | 24 |
| MERCY HOSPITAL ARDMORE | Ardmore | E20 Health Care | $176.9M | 13 |
| Charles and Lynn Schusterman Family Foundation | Tulsa | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $175.5M | 0 |
| Oklahoma Blood Institute | Oklahoma City | E61Z Health Care | $146.2M | 27 |
| COMMUNITIES FOUNDATION OF OKLAHOMA | Oklahoma City | T30J Philanthropy, Voluntarism & Grantmaking Foundations | $142.7M | 1 |
| FAMILY & CHILDRENS SERVICES INC | Tulsa | P400 Human Services | $137.5M | 7 |
| INTEGRIS HEALTH EDMOND INC | Oklahoma City | E22 Health Care | $125.6M | 12 |
| MERCY HOSPITAL ADA INC | Ada | — | $118.2M | 11 |
| Oklahoma Medical Research Foundation | Oklahoma City | H920 Medical Research | $114.3M | 18 |
| THE SAMUEL ROBERTS NOBLE FOUNDATION | Ardmore | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $114.2M | 17 |
| OKLAHOMA CITY UNIVERSITY | Oklahoma City | B430 Education | $112.3M | 17 |
| TRI-COUNTY ELECTRIC COOPERATIVE INC | Hooker | — | $103.8M | 21 |
| REGIONAL FOOD BANK OF OKLAHOMA INC | Oklahoma City | K310 Food, Agriculture & Nutrition | $99.4M | 7 |
| VARIETY CARE INC | Oklahoma City | E32Z Health Care | $97.8M | 16 |
| Oklahoma Baptist University | Shawnee | B420 Education | $96.6M | 8 |
| THE CHILDREN'S CENTER INC | Bethany | E910 Health Care | $95.9M | 11 |
| VERDIGRIS VALLEY ELECTRIC | Collinsville | — | $93.6M | 20 |
| CENTRAL OKLAHOMA AMERICAN INDIAN | Oklahoma City | E320 Health Care | $92.6M | 16 |
| Citgo Petroleum Corporation | Tulsa | — | $91.2M | 1 |
| NORTHEAST OKLAHOMA ELECTRIC COOPERATIVE | Vinita | — | $90.2M | 16 |
| CKENERGY ELECTRIC COOPERATIVE INC | Binger | — | $87.2M | 23 |
| COTTON ELECTRIC COOPERATIVE INC | Walters | — | $83.2M | 18 |
| Canadian Valley Electric Cooperative Inc | Seminole | — | $78.5M | 16 |
| OKLAHOMA CITY COMMUNITY FOUNDATION INC | Oklahoma City | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $77.8M | 12 |
| CENTRAL RURAL ELECTRIC COOPERATIVE INC | Stillwater | — | $77.6M | 17 |
| Oklahoma Mental Health Council | Oklahoma City | F32Z Mental Health & Crisis Intervention | $77.1M | 11 |
| CREOKS MENTAL HEALTH SERVICES | Tulsa | F30Z Mental Health & Crisis Intervention | $76.8M | 14 |
| CIMARRON ELECTRIC COOPERATIVE INC | Kingfisher | — | $76M | 19 |
