| FAMILY TREE INC | Wheatridge | P200 Human Services | $12.5M | 5 |
| THE CLUB AT ROLLING HILLS | Golden | — | $12.4M | 6 |
| WALDORF SCHOOL ASSOCIATION OF BOULDER INC | Boulder | — | $12.4M | 4 |
| ASPEN PREP ACADEMY | Greenwood Village | B24 Education | $12.4M | 2 |
| MESA COUNTY LAND CONSERVANCY INC | Grand Junction | C340 Environment | $12.4M | 1 |
| ADDENBROOKE CLASSICAL ACADEMY INC | Lakewood | B20 Education | $12.4M | 0 |
| COLORADANS FOR RESPONSIBLE ENERGY DEVELOPMENT | Englewood | Z99 Unknown | $12.4M | 0 |
| Cadence International | Englewood | — | $12.3M | 5 |
| World Compass Academy | Castle Rock | B29 Education | $12.3M | 3 |
| SunWest Educational Credit Union | Pueblo | — | $12.2M | 9 |
| GREELEY AREA HABITAT FOR HUMANITY | Greeley | L20Z Housing & Shelter | $12.2M | 2 |
| Vive | Denver | O50 Youth Development | $12.2M | 1 |
| THE BOULDER JEWISH COMMUNITY CENTER | Boulder | P28 Human Services | $12.1M | 4 |
| KEYSTONE SYMPOSIA ON MOLECULAR AND CELLULAR BIOLOGY | Silverthorne | U50 Science & Technology | $12.1M | 6 |
| BSCS SCIENCE LEARNING | Colorado Springs | — | $12.1M | 11 |
| AMERICAN ANIMAL HOSPITAL ASSOCIATION | Lakewood | — | $12.1M | 9 |
| Parker Core Knowledge Inc | Parker | B29 Education | $12M | 5 |
| FLATIRONS ACADEMY | Westminster | B24 Education | $12M | 3 |
| HOVER SENIOR LIVING COMMUNITY | Longmont | — | $11.9M | 0 |
| UNITED STATES FIELD HOCKEY ASSOCIATION INC | Colorado Springs | N600 Recreation & Sports | $11.9M | 4 |
| Loveland Elder Green House Homes for Life Enrichment | Loveland | L22 Housing & Shelter | $11.9M | 6 |
| Cheyenne Village | Colorado Springs | P800 Human Services | $11.8M | 2 |
| MINNEQUA WORKS CREDIT UNION | Pueblo | W61 Public & Societal Benefit | $11.7M | 13 |
| DENVER JEWISH DAY SCHOOL | Denver | B25 Education | $11.7M | 2 |
| International Brotherhood of Teamsters Local Union No 455 | Denver | — | $11.7M | 13 |
| HABITAT FOR HUMANITY ROARING FORK | Glenwood Springs | — | $11.6M | 4 |
| PYRAMID MODEL CONSORTIUM | Fort Collins | B99 Education | $11.6M | 0 |
| COMMUNITY HEALTH PROVIDER ALLIANCE | Denver | P20 Human Services | $11.5M | 5 |
| THE ST FRANCIS CENTER | Denver | — | $11.5M | 3 |
| ROUNDUP FELLOWSHIP | Denver | P700 Human Services | $11.5M | 4 |
| ZEFF KESHER FOUNDATION | Denver | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $11.5M | 0 |
| JUNIOR ACHIEVEMENT USA HEALTH & WELFARE BENEFIT PLAN TRUST | Colorado Springs | — | $11.5M | 4 |
| UPTOWN COMMUNITY HEALTH CENTER INC | Denver | E32 Health Care | $11.4M | 6 |
| Dr James Dobson Family Institute | Colorado Springs | X83 Religion-Related | $11.4M | 4 |
| TENNYSON CENTER FOR CHILDREN AT COLORADO CHRISTIAN HOME | Denver | P30 Human Services | $11.3M | 5 |
| AXL Academy Charter School | Aurora | B24 Education | $11.3M | 2 |
| INNER CITY HEALTH CENTER | Denver | F32Z Mental Health & Crisis Intervention | $11.3M | 11 |
| FLAGSTAFF ACADEMY | Longmont | B29 Education | $11.3M | 3 |
| UTILITY NOTIFICATION CENTER OF COLORADO | Golden | — | $11.3M | 6 |
| CAPROCK ACADEMY | Grand Junction | B29 Education | $11.3M | 2 |
| WELD LEGACY FOUNDATION | Greeley | E110 Health Care | $11.2M | 3 |
| The Word for the World USA | Colorado Springs | X20 Religion-Related | $11.2M | 2 |
| BIEBER FAMILY FOUNDATION | Denver | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $11.2M | 0 |
| PIKES PEAK COMMUNITY FOUNDATION | Colorado Springs | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $11.2M | 4 |
| NOCO HUMANE | Loveland | D200 Animal-Related | $11.2M | 2 |
| UNIVERSITY PREPARATORY SCHOOLS | Denver | B29 Education | $11.2M | 2 |
| FUND FOR THE NEW SCHOOL BOULDER COUNTRY DAY SCHOOL | Boulder | — | $11.2M | 6 |
| VALLEY COUNTRY CLUB | Centennial | — | $11.1M | 6 |
| Cherry Hills Christian School | Highlands Ranch | B24 Education | $11.1M | 3 |
| JEWISH COMMUNITY CENTERS OF DENVER | Denver | P28Z Human Services | $11.1M | 4 |
