| ST ANNE'S NURSING CENTER ST ANNE'S RESIDENCE INC | Miami | E91 Health Care | $24.5M | 6 |
| FIRST COAST COMMUNITY DEVELOPMENT INC | Jacksonville | P20 Human Services | $24.4M | 0 |
| JONATHAN'S LANDING GOLF CLUB INC | Jupiter | N50 Recreation & Sports | $24.3M | 7 |
| VISITING NURSE ASSOCIATION OF FLORIDA INC | Stuart | — | $24.2M | 15 |
| Carpenter's Home Estates Inc | Lakeland | — | $24.2M | 5 |
| MIAMI CITY BALLET INC | Miami Beach | A630 Arts, Culture & Humanities | $24.2M | 9 |
| EARLY LEARNING COALITION OF MARION COUNTY INC | Ocala | B032 Education | $24.2M | 1 |
| K9S FOR WARRIORS INC | Ponte Vedra | D99 Animal-Related | $24.2M | 15 |
| AMERICAN MARITIME OFFICERS SAFETY & EDUCATION PLAN | Dania Beach | B600 Education | $24.1M | 2 |
| Boys and Girls Club of Northeast Florida Inc | Jacksonville | O23Z Youth Development | $24.1M | 5 |
| SIGHTLIFE | Tampa | S80Z Community Improvement & Capacity Building | $24.1M | 2 |
| WONDERFUL LIFE FOUNDATION | West Palm Beach | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $24.1M | 0 |
| FEED THE HUNGRY PANTRY OF PALM BEACH COUNTY INC | Palm Beach Gardens | K30 Food, Agriculture & Nutrition | $24M | 0 |
| DR PHILLIPS INC | Orlando | T11 Philanthropy, Voluntarism & Grantmaking Foundations | $24M | 11 |
| HOMELESS SERVICES NETWORK OF CENTRAL FLORIDA INC | Orlando | P85Z Human Services | $24M | 3 |
| MENORAH MANOR INC | St Petersburg | P75Z Human Services | $24M | 7 |
| SUNRISE COMMUNITY OF TENNESSEE INC | Miami | P820 Human Services | $23.9M | 4 |
| LOURDES-NOREEN MCKEEN RESIDENCE FOR GERIATRIC CARE INC | West Palm Beach | P750 Human Services | $23.9M | 6 |
| EARLY LEARNING COALITION OF INDIAN RIVER MARTIN & OKEECHOBEE COUNTIES | Stuart | B039 Education | $23.9M | 1 |
| ROYAL POINCIANA GOLF CLUB INC | Naples | — | $23.9M | 7 |
| EDWARDSON FAMILY FOUNDATION | Boca Grande | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $23.9M | 0 |
| THE NATIONAL BEN GAMLA CHARTER SCHOOL FOUNDATION INC | Miami | B29 Education | $23.8M | 3 |
| UNITED STATES SPECIALTY SPORTS ASSOCIATION INC | Melbourne | — | $23.6M | 16 |
| WEALTH WATCHERS INC | Jacksonville | L22 Housing & Shelter | $23.5M | 3 |
| SUNCOAST CENTER INC | St Petersburg | F32Z Mental Health & Crisis Intervention | $23.5M | 12 |
| THE CHILDREN'S HOME INC | Tampa | F330 Mental Health & Crisis Intervention | $23.4M | 7 |
| VIZCAYA MUSEUM AND GARDENS TRUST INC | Miami | A80 Arts, Culture & Humanities | $23.4M | 11 |
| SAVE OUR MUSICIANS FOUNDATION INC | Jupiter | A11 Arts, Culture & Humanities | $23.3M | 0 |
| DRS KIRAN & PALLAVI PATEL 2017 FOUNDATION FOR GLOBAL UNDERSTANDING INC | Tampa | B90 Education | $23.3M | 0 |
| THE AGRICULTURAL AND LABOR PROGRAM INC | Winter Haven | K300 Food, Agriculture & Nutrition | $23.3M | 2 |
| CONVIVIAL LIFE INC | Venice | L22 Housing & Shelter | $23.2M | 0 |
| MAKE-A-WISH FOUNDATION OF SOUTHERN FLORIDA INC | Miami | E86Z Health Care | $23.2M | 8 |
| ANC HEALTHCARE INC | Winter Park | E210 Health Care | $23.2M | 0 |
| NEXTERA ENERGY FOUNDATION INC | Juno Beach | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $23.2M | 0 |
| SOUTH FLORIDA PBS INC | Boynton Beach | A320 Arts, Culture & Humanities | $23.1M | 9 |
| ORLANDO CREDIT UNION | Orlando | — | $23.1M | 7 |
| SHADOW WOOD COUNTRY CLUB INC | Bonita Springs | N50 Recreation & Sports | $23M | 8 |
| Orange Bowl Committee Inc | Miami Lakes | B42 Education | $22.9M | 7 |
| AVE MARIA SCHOOL OF LAW | Naples | B50 Education | $22.9M | 7 |
| FLORIDA STATE UNIVERSITY INTERNATIONAL PROGRAMS ASSOCATION INC | Tallahassee | — | $22.9M | 13 |
| Clearwater Marine Aquarium Inc | Clearwater | D500 Animal-Related | $22.9M | 11 |
| SARASOTA-MANATEE JEWISH HOUSING COUNCIL INC | Sarasota | P750 Human Services | $22.9M | 8 |
| TAMPA MUSEUM OF ART INC | Tampa | A510 Arts, Culture & Humanities | $22.8M | 4 |
| EPIC CURE INC | St Augustine | O50 Youth Development | $22.8M | 0 |
| PHILLIP AND PATRICIA FROST MUSEUM OF SCIENCE INC | Miami | A570 Arts, Culture & Humanities | $22.8M | 12 |
| OCEAN REEF COMMUNITY FOUNDATION INC | Key Largo | T70 Philanthropy, Voluntarism & Grantmaking Foundations | $22.6M | 2 |
| EPWORTH VILLAGE WEST INC | Hialeah | L220 Housing & Shelter | $22.5M | 1 |
| Cove Behavioral Health Inc | Tampa | F22O Mental Health & Crisis Intervention | $22.3M | 8 |
| THE ZOOLOGICAL SOCIETY OF THE PALM BEACHES INC | West Palm Beach | D500 Animal-Related | $22.3M | 5 |
| BOLEY CENTERS INC | St Petersburg | F300 Mental Health & Crisis Intervention | $22.2M | 4 |
