| Maine Public Broadcasting Corporation | Lewiston | A320 Arts, Culture & Humanities | $24.6M | 9 |
| Penobscot Valley Hospital | Lincoln | E20 Health Care | $23.6M | 8 |
| FIVE COUNTY CREDIT UNION | Bath | — | $23.6M | 7 |
| Fryeburg Academy | Fryeburg | B25Z Education | $23.4M | 2 |
| PEOPLESCHOICE CREDIT UNION | Saco | — | $23.1M | 7 |
| Portland Community Health Center | Portland | E32 Health Care | $23.1M | 8 |
| Hospice of Southern Maine | Scarborough | P74 Human Services | $22.8M | 8 |
| New Communities Inc | Westbrook | L21 Housing & Shelter | $22.5M | 7 |
| Waypoint Maine Inc | Sanford | P820 Human Services | $22.5M | 1 |
| Maine-Dartmouth Family Medicine | Augusta | B54Z Education | $22M | 15 |
| DECOSTER FAMILY CHARITABLE | Turner | X12 Religion-Related | $22M | 0 |
| St Joseph's Rehabilitation & Residence | Portland | E91 Health Care | $21.5M | 12 |
| Jobs for Maine's Graduates Inc | Augusta | — | $20.7M | 5 |
| GULF OF MAINE RESEARCH INSTITUTE | Portland | D500 Animal-Related | $20.2M | 10 |
| AROOSTOOK COUNTY ACTION PROGRAM | Presque Isle | I720 Crime & Legal-Related | $20.2M | 4 |
| DOWNEAST CREDIT UNION | Baileyville | — | $19.5M | 7 |
| EVELYN S AND K E BARRETT FOUNDATION | York | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $19.4M | 2 |
| OHI | Bangor | P73 Human Services | $19.3M | 4 |
| MORRISON CENTER | Scarborough | G23Z Diseases, Disorders & Medical Disciplines | $19.3M | 1 |
| WALDO COMMUNITY ACTION PARTNERS | Belfast | P20 Human Services | $19.2M | 4 |
| MOTIVATIONAL SERVICES INC | Augusta | F34Z Mental Health & Crisis Intervention | $19M | 2 |
| JHA SERVICES | Portland | — | $19M | 9 |
| EASTERN MAINE ELECTRIC COOPERATIVE INC | Calais | — | $18.4M | 18 |
| Acadia Healthcare Inc | Brewer | E200 Health Care | $18.1M | 18 |
| Northern Light Health Foundation | Brewer | E200 Health Care | $17.7M | 9 |
| Better World Libraries | Biddeford | A30 Arts, Culture & Humanities | $17.2M | 0 |
| GOULD ACADEMY | Bethel | B250 Education | $16.6M | 4 |
| WABANAKI HEALTH & WELLNESS NPC | Bangor | F99 Mental Health & Crisis Intervention | $16.1M | 5 |
| CASA INC | Westbrook | P730 Human Services | $15.9M | 2 |
| Volunteers of America Northern | Brunswick | — | $15.9M | 4 |
| Community Clinical Services Inc | Lewiston | E32Z Health Care | $15.5M | 11 |
| Portland Museum of Art | Portland | A510 Arts, Culture & Humanities | $15.4M | 8 |
| SHAW BROTHERS FAMILY FOUNDATION | Gorham | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $15.2M | 0 |
| North Yarmouth Academy | Yarmouth | B250 Education | $15.1M | 6 |
| INITIATIVE FOR DIGITAL ENGINEERING | Falmouth | — | $15M | 2 |
| PORT RESOURCES INC | South Portland | P820 Human Services | $14.7M | 2 |
| Maine Health Access Foundation Inc | Augusta | E12 Health Care | $14.6M | 4 |
| SPECTRUM GENERATIONS | Augusta | P81Z Human Services | $14.6M | 2 |
| Atlantic Salmon Federation (US) Inc | Calais | D330 Animal-Related | $14.5M | 2 |
| CEDARS NURSING CARE CENTER | Portland | E91Z Health Care | $14.5M | 9 |
| Health Access Network Inc | Lincoln | E320 Health Care | $14.4M | 7 |
| Friends of Acadia | Bar Harbor | C340 Environment | $14.3M | 7 |
| DOWNEAST COMMUNITY PARTNERS INC | Ellsworth | P300 Human Services | $14.3M | 2 |
| Maine Central Institute | Pittsfield | B250 Education | $14.1M | 3 |
| MaineGeneral Health | Augusta | E22 Health Care | $14.1M | 10 |
| Mount Desert Island Biological | Salisbury Cove | U500 Science & Technology | $14.1M | 10 |
| St Joseph Healthcare Foundation | Bangor | W12 Public & Societal Benefit | $13.9M | 6 |
| FISH RIVER RURAL HEALTH | Eagle Lake | E700 Health Care | $13.8M | 6 |
| AVESTA HOUSING DEVELOPMENT CORPORATION | Portland | L210 Housing & Shelter | $13.5M | 6 |
| John T Gorman Foundation | Portland | T21J Philanthropy, Voluntarism & Grantmaking Foundations | $13.3M | 2 |
