| Sweetser | Saco | P300 Human Services | $50.2M | 7 |
| Trustees of Saint Joseph's College | Standish | B430 Education | $48.1M | 11 |
| THE BLUE HILL MEMORIAL HOSPITAL | Blue Hill | E22Z Health Care | $43.7M | 21 |
| ALPHA ONE | Portland | P44Z Human Services | $43.4M | 5 |
| WOODFORDS FAMILY SERVICES | Westbrook | B28Z Education | $43.3M | 7 |
| VNA Home Health & Hospice | South Portland | E920 Health Care | $43M | 16 |
| KENNEBEC VALLEY COMMUNITY ACTION | Waterville | P200 Human Services | $42.4M | 6 |
| KENNEBEC VALLEY MENTAL HEALTH CENTE | Waterville | F80Z Mental Health & Crisis Intervention | $41.8M | 8 |
| HealthReach Community Health Centers | Waterville | E39Z Health Care | $40.5M | 7 |
| Wreaths Across America | Columbia Falls | W30 Public & Societal Benefit | $40.2M | 5 |
| THOMAS COLLEGE | Waterville | B420 Education | $40M | 8 |
| COASTAL ENTERPRISES INC | Brunswick | L21 Housing & Shelter | $39.9M | 9 |
| LUNDER FOUNDATION | Portland | — | $38.3M | 0 |
| Shalom House Inc | Portland | F33Z Mental Health & Crisis Intervention | $37.9M | 3 |
| Medical Care Development Inc | Hallowell | E21Z Health Care | $37.2M | 13 |
| The Opportunity Alliance | South Portland | P20 Human Services | $36.5M | 7 |
| Maine Technology Institute | Brunswick | B29 Education | $36.2M | 2 |
| Maine Financial Institutions | Westbrook | Y43 Mutual & Membership Benefit | $34.8M | 3 |
| MAINE AUTOMOBILE DEALERS | Augusta | E81Z Health Care | $33.4M | 1 |
| KATAHDIN VALLEY HEALTH CENTER | Patten | E32Z Health Care | $33.1M | 8 |
| TRUSTEES OF THORNTON ACADEMY | Saco | B25Z Education | $33.1M | 7 |
| Millinocket Regional Hospital | Millinocket | E220 Health Care | $31.8M | 13 |
| COMMUNITY HEALTH AND COUNSELING SERVICES | Bangor | F320 Mental Health & Crisis Intervention | $31.4M | 10 |
| Catholic Charities Maine | Portland | P200 Human Services | $30.8M | 7 |
| SENIORSPLUS | Lewiston | P810 Human Services | $30.8M | 2 |
| Bigelow Laboratory for Ocean Sciences | East Boothbay | U210 Science & Technology | $30.5M | 16 |
| MAINE STATE CREDIT UNION | Augusta | — | $30.2M | 11 |
| MAINE COLLEGE OF ART AND DESIGN | Portland | B420 Education | $29.8M | 5 |
| CPORT CREDIT UNION | Portland | — | $29.7M | 7 |
| COLLEGE OF THE ATLANTIC | Bar Harbor | — | $29.6M | 7 |
| WAYNFLETE SCHOOL | Portland | B200 Education | $29.5M | 7 |
| UNIVERSITY CREDIT UNION | Orono | — | $29.3M | 11 |
| Maine Life Care Retirement Community Inc | Scarborough | L22 Housing & Shelter | $28.9M | 6 |
| PREBLE STREET | Portland | P300 Human Services | $28.7M | 5 |
| EVERGREEN CREDIT UNION | Portland | — | $28.4M | 9 |
| LifeFlight of Maine LLC | Bangor | M23 Public Safety, Disaster Preparedness & Relief | $28.3M | 2 |
| YORK COUNTY COMMUNITY ACTION | Sanford | P20Z Human Services | $28.1M | 8 |
| Pines Health Services | Caribou | E20 Health Care | $27.4M | 8 |
| Calais Community Hospital | Calais | E22 Health Care | $27.4M | 9 |
| TD CHARITABLE FOUNDATION | Portland | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $27.3M | 0 |
| AROOSTOOK MENTAL HEALTH | Presque Isle | F80 Mental Health & Crisis Intervention | $27.2M | 4 |
| Creative Works | Westbrook | J300 Employment | $27M | 7 |
| Community Concepts Inc | Lewiston | — | $26.9M | 7 |
| BERWICK ACADEMY | South Berwick | B200 Education | $26.8M | 8 |
| Maine Coast Heritage Trust | Topsham | C340 Environment | $26.6M | 6 |
| MaineHealth Services | Portland | E12 Health Care | $26.3M | 10 |
| KENTS HILL SCHOOL | Kents Hill | — | $25.4M | 7 |
| Onpoint Health Data | Portland | E00L Health Care | $25.4M | 7 |
| MAINEHEALTH CARE AT HOME | Saco | E92 Health Care | $25.4M | 12 |
| Charles A Dean Memorial Hospital | Greenville | E200 Health Care | $24.6M | 18 |
