| ROBOTICS EDUCATION & COMPETITION FOUNDATION INC | Greenville | B99 Education | $22.1M | 1 |
| Mobility Credit Union | Irving | — | $22.1M | 7 |
| COMMUNITY HEALTH DEVELOPMENT INC | Uvalde | E320 Health Care | $22.1M | 13 |
| LIFTFUND INC | San Antonio | S43 Community Improvement & Capacity Building | $22.1M | 6 |
| AMERICAS CREDIT UNION | Garland | — | $22M | 14 |
| LOUISIANA CLINICAL SERVICES INC | Austin | — | $22M | 0 |
| The Urban Alternative | DeSoto | X800 Religion-Related | $22M | 6 |
| Jarvis Christian University | Hawkins | — | $22M | 5 |
| LTTS CHARTER SCHOOL INC DBA UNIVERSAL ACADEMY | Irving | B20P Education | $22M | 5 |
| THE ADDY FOUNDATION | Dallas | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $22M | 1 |
| RESOURCE CENTER OF DALLAS INC | Dallas | G81Z Diseases, Disorders & Medical Disciplines | $21.9M | 6 |
| PEDIATRIC HEALTH MANAGEMENT SERVICES | Dallas | — | $21.9M | 11 |
| CHRISTUS CHILDREN'S FOUNDATION | San Antonio | E24Z Health Care | $21.9M | 0 |
| SHARYLAND WATER SUPPLY CORPORATION | Alton | — | $21.8M | 1 |
| LAKESIDE COUNTRY CLUB | Houston | — | $21.8M | 8 |
| SEMMES FOUNDATION INC | San Antonio | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $21.8M | 1 |
| COMMISSION TO EVERY NATION | Kerrville | X20 Religion-Related | $21.8M | 3 |
| MCT CREDIT UNION | Port Neches | — | $21.7M | 8 |
| PAEON HEALTH SERVICES INC | Austin | E60 Health Care | $21.7M | 8 |
| THE CITIZENS FOUNDATION USA | Houston | P12 Human Services | $21.7M | 3 |
| MUNICIPAL GOLF ASSOCIATION - SA | San Antonio | N6A Recreation & Sports | $21.7M | 5 |
| Houston Hospice | Houston | — | $21.7M | 10 |
| ABILENE GOODWILL INDUSTRIES INC | Abilene | J32Z Employment | $21.6M | 3 |
| ORENDA EDUCATION | Georgetown | F20 Mental Health & Crisis Intervention | $21.6M | 3 |
| 15TH STREET FOUNDATION | Dallas | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $21.6M | 0 |
| TRINITY BROADCASTING OF FLORIDA | Fort Worth | X840 Religion-Related | $21.5M | 10 |
| Trustees of Shannon West Texas Memorial Hospital | San Angelo | E110 Health Care | $21.5M | 8 |
| GREENBELT ELECTRIC COOPERATIVE INC | Wellington | — | $21.5M | 14 |
| AUSTIN HABITAT FOR HUMANITY INC | Austin | — | $21.4M | 10 |
| EARTH DAY TEXAS INC | Dallas | N52 Recreation & Sports | $21.4M | 4 |
| The Wildcat Foundation | Fort Worth | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $21.4M | 0 |
| HOUSTON LIVESTOCK SHOW AND RODEO EDUCATIONAL FUND | Houston | N520 Recreation & Sports | $21.3M | 3 |
| SAFARI CLUB INTERNATIONAL | San Antonio | D013 Animal-Related | $21.3M | 6 |
| PLUMBERS' LOCAL UNION NO 68 WELFARE FUND | Houston | — | $21.3M | 0 |
| THE WOODFOREST CHARITABLE FOUNDATION | The Woodlands | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $21.3M | 0 |
| ContinueCare Hospital of Tyler Inc | Plano | E20 Health Care | $21.3M | 9 |
| SAN ANTONIO METROPOLITAN MINISTRIES INC | San Antonio | — | $21.3M | 5 |
| DISABILITY RIGHTS TEXAS | Austin | R23Z Civil Rights, Social Action & Advocacy | $21.2M | 11 |
| HERMANN SONS LIFE | San Antonio | — | $21.2M | 11 |
| HOSPICE OF EAST TEXAS | Tyler | — | $21.2M | 7 |
| GIRL SCOUTS OF NORTHEAST TEXAS | Dallas | O42 Youth Development | $21.1M | 8 |
| TEXAS HEALTH ACTION | Austin | E32 Health Care | $21.1M | 4 |
| HELEN JONES FOUNDATION INC | Lubbock | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $21M | 2 |
| SER-NINOS INC DBA SER NINOS CHARTER SCHOOL | Houston | B24P Education | $21M | 1 |
| INCARNATE WORD RETIREMENT COMMUNITY INC | San Antonio | — | $21M | 8 |
| CAHRMC | Eagle Lake | E20 Health Care | $20.8M | 1 |
| H E BUTT FOUNDATION | Kerrville | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $20.8M | 2 |
| CHILD INC | Austin | B210 Education | $20.7M | 2 |
| Mercy Restorative Care Hospital Inc | Plano | E20 Health Care | $20.7M | 10 |
| Gateway Foundation - Texas | Houston | F200 Mental Health & Crisis Intervention | $20.7M | 3 |
