| Presbyterian Healthcare Foundation | Albuquerque | E11 Health Care | $14.2M | 3 |
| Community Foundation of Southern New Mexico | Las Cruces | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $14.2M | 1 |
| NMC INC | Los Alamos | B12 Education | $14.1M | 8 |
| MORA-SAN MIGUEL ELECTRIC COOPERATIVE INC | Mora | — | $13.9M | 10 |
| COLLABORATIVE FOR HIGHER EDUCATION SHARED SERVICES | Santa Fe | B02 Education | $13.9M | 3 |
| FAMILIES AND YOUTH INC | Las Cruces | P200 Human Services | $13.8M | 1 |
| SYNCRONYS | Albuquerque | E21 Health Care | $13.7M | 5 |
| CARC INC | Carlsbad | P700 Human Services | $13.5M | 5 |
| GUIDANCE CENTER OF LEA COUNTY INC | Hobbs | F32Z Mental Health & Crisis Intervention | $13.2M | 4 |
| NEW MEXICO LEGAL AID INC | Albuquerque | I80 Crime & Legal-Related | $13.1M | 7 |
| Bosque School | Albuquerque | B250 Education | $13M | 4 |
| HEADING HOME | Albuquerque | L41 Housing & Shelter | $13M | 3 |
| THORNBURG FOUNDATION | Santa Fe | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $12.9M | 1 |
| TOBOSA DEVELOPMENT AND TRAINING CENTER INC | Roswell | J30Z Employment | $12.8M | 2 |
| UNIVERSITY OF NEW MEXICO RETIREE WELFARE BENEFIT TRUST | Albuquerque | Y44 Mutual & Membership Benefit | $12.8M | 1 |
| NEW MEXICO COMMUNITY FOUNDATION | Santa Fe | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $12.7M | 3 |
| ZIA CREDIT UNION | Los Alamos | W61 Public & Societal Benefit | $12.5M | 6 |
| INDEPENDENT LIVING RESOURCE CENTER | Albuquerque | P80Z Human Services | $12.4M | 6 |
| SIERRA ELECTRIC COOPERATIVE INC | Elephant Butte | — | $12.3M | 15 |
| DONA ANA MUTUAL DOMESTIC WATER CONSUMERS ASSOCIATION | Dona Ana | — | $12.1M | 0 |
| AMERICAN INDIAN SCIENCE AND ENGINEERING SOCIETY | Albuquerque | — | $12M | 7 |
| ALTA MIRA SPECIALIZED FAMILY SERVICES INC | Albuquerque | P8XZ Human Services | $11.7M | 3 |
| ALL FAITHS | Albuquerque | P400 Human Services | $11.7M | 5 |
| COMMUNITY ACTION AGENCY OF SOUTHERN NEW MEXICO INC | Las Cruces | P20Z Human Services | $11.6M | 3 |
| CNM HOLDINGS INC | Albuquerque | — | $11.5M | 3 |
| WESTERN NEW MEXICO UNIVERSITY FOUND | Silver City | B43I Education | $11.5M | 1 |
| LANNAN FOUNDATION | Santa Fe | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $11.4M | 8 |
| EIGHT NORTHERN INDIAN PUEBLOS COUNCIL INC | Ohkay Owingeh | S20 Community Improvement & Capacity Building | $11.3M | 0 |
| SCHOOL FOR ADVANCED RESEARCH | Santa Fe | V21 Social Science | $11.2M | 2 |
| SHIPROCK ASSOCIATED SCHOOLS INC | Shiprock | B200 Education | $11.1M | 6 |
| SANTA MARIA EL MIRADOR | Santa Fe | P20 Human Services | $11.1M | 2 |
| SANTA FE PREPARATORY SCHOOL | Santa Fe | B250 Education | $11M | 5 |
| GEORGIA O'KEEFFE MUSEUM | Santa Fe | A510 Arts, Culture & Humanities | $10.9M | 8 |
| MIDWEST NEW MEXICO COMMUNITY ACTION PROGRAM | Los Lunas | — | $10.9M | 4 |
| Sacramento Mountains Foundation Inc | Alamogordo | R20 Civil Rights, Social Action & Advocacy | $10.8M | 11 |
| SOUTHEAST NM COMMUNITY ACTION CORPORATION | Carlsbad | P20Z Human Services | $10.7M | 1 |
| ALBUQUERQUE HEALTH CARE FOR THE HOMELESS INC | Albuquerque | P85Z Human Services | $10.7M | 8 |
| NEW MEXICO COALITION OF SEXUAL ASSAULT PROGRAMS | Albuquerque | — | $10.7M | 2 |
| SOUTHWESTERN LINE CONSTRUCTION ELECT JOINT APPRENTICESHIP & TRAINING PROGRAM | Albuquerque | J22Z Employment | $10.7M | 13 |
| CONQUISTADOR COUNCIL BSA TRUST FUND | Roswell | O110 Youth Development | $10.5M | 1 |
| RETIREMENT RANCHES INC | Clovis | — | $10.5M | 2 |
| INDIGENOUS EDUCATION INC | Albuquerque | B82 Education | $10.1M | 1 |
| RGEC INC | Albuquerque | B90 Education | $9.9M | 7 |
| CENTER FOR ENVIRONMENTAL HEALTH MONITORING AND MANAGEMENT | Carlsbad | U400 Science & Technology | $9.8M | 2 |
| THREE RIVERS EDUCATION FOUNDATION INC | Farmington | B99 Education | $9.6M | 0 |
| LOS ALAMOS NATIONAL LABORATORY FOUNDATION | Espanola | B120 Education | $9.6M | 6 |
| JF Maddox Foundation | Hobbs | B82 Education | $9.6M | 11 |
| Albuquerque Sign Language Academy | Albuquerque | B29 Education | $9.6M | 1 |
| THE LIFE LINK | Santa Fe | O20Z Youth Development | $9.5M | 3 |
| NEW MEXICO ASSOCIATION OF COUNTIES | Santa Fe | — | $9.4M | 8 |
