| Alliance Preparatory Schools Inc | Charlotte | — | $25.8M | 0 |
| DreamKey Partners Inc | Charlotte | L210 Housing & Shelter | $25.7M | 7 |
| Wake Preparatory Academy | Wake Forest | B29 Education | $25.5M | 0 |
| The Methodist Home for Children Inc | Raleigh | P730 Human Services | $25.5M | 7 |
| Z SMITH REYNOLDS FOUNDATION INC | Winstonsalem | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $25.3M | 15 |
| Lowes Foundation | Mooresville | B12 Education | $25.3M | 6 |
| NORTH CAROLINA COASTAL FEDERATION INC | Newport | — | $25.2M | 6 |
| NATIONAL COLLEGE ADVISING CORPS INC | Raleigh | B80 Education | $25M | 10 |
| DAVIDSON WATER INC | Welcome | — | $25M | 21 |
| UNC MANAGEMENT COMPANY INC | Chapel Hill | — | $25M | 13 |
| MOSES CONE MEDICAL SERVICES INC | Greensboro | E110 Health Care | $25M | 12 |
| THE CANNON FOUNDATION INC | Concord | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $24.8M | 10 |
| MOSES CONE PHYSICIAN SERVICES INC | Greensboro | E30 Health Care | $24.8M | 12 |
| LIFE ST JOSEPH OF THE PINES INC | Fayetteville | — | $24.7M | 12 |
| UNION ACADEMY | Monroe | B29 Education | $24.7M | 4 |
| STATE CHARTERED CREDIT UNIONS IN NORTH CAROLINA | Greensboro | — | $24.4M | 2 |
| Winston Salem Industries for the Blind Inc | Winstonsalem | J33Z Employment | $24.4M | 14 |
| NORTH CAROLINA SPORTS LEGACY FOUNDATION FKA PROMOTE THE YOUTH FOUNDATION | Charlotte | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $24.1M | 0 |
| MYERS PARK COUNTRY CLUB INC | Charlotte | N50 Recreation & Sports | $24.1M | 6 |
| Lincoln Charter School Inc | Denver | B20 Education | $24M | 4 |
| ROOF ABOVE INC | Charlotte | A23Z Arts, Culture & Humanities | $24M | 5 |
| YOUNG MEN'S CHRISTIAN ASSOCIATION OF CATAWBA VALLEY INC | Hickory | P27Z Human Services | $23.8M | 3 |
| THE NATURAL SCIENCE CENTER OF GREENSBORO INC DBA GREENSBORO SCIENCE CENTER | Greensboro | A560 Arts, Culture & Humanities | $23.7M | 2 |
| MOUNTAIN PROJECTS INC | Waynesville | — | $23.7M | 2 |
| Country Club of Landfall | Wilmington | P20 Human Services | $23.6M | 6 |
| Carolina Day School Inc | Asheville | B24Z Education | $23.5M | 7 |
| ROWAN-CABARRUS YOUNG MEN'S CHRISTIAN ASSOCIATION | Salisbury | P27Z Human Services | $23.5M | 4 |
| EDUCATIONAL FOUNDATION SCHOLARSHIP ENDOWMENT TRUST | Chapel Hill | B820 Education | $23.4M | 5 |
| UWHARRIE GREEN SCHOOL INC | Asheboro | B29 Education | $23.3M | 2 |
| Saint Marys School | Raleigh | B410 Education | $23.3M | 8 |
| THE CYPRESS OF RALEIGH CLUB INC | Raleigh | N99 Recreation & Sports | $23.3M | 5 |
| Charlotte Sports Foundation | Charlotte | N40 Recreation & Sports | $23.3M | 2 |
| PACE AT HOME INC | Newton | E50 Health Care | $23.2M | 4 |
| NORTH CAROLINA BIOTECHNOLOGY CENTER | Research Triangle Park | U500 Science & Technology | $23.1M | 9 |
| Greensboro College | Greensboro | B420 Education | $23.1M | 5 |
| FOUNDATION OF THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE | Charlotte | — | $22.9M | 3 |
| UNITED STATES BASEBALL FEDERATION INC | Cary | — | $22.7M | 9 |
| THE TIMOTHY INITIATIVE INC | Raleigh | X20 Religion-Related | $22.7M | 7 |
| BARIUM SPRINGS HOME FOR CHILDREN | Barium Springs | P73 Human Services | $22.6M | 7 |
| TRIANGLE RESIDENTIAL OPTIONS FOR SUBSTANCE ABUSERS INC | Durham | — | $22.5M | 7 |
| INSTITUTE FOR MEDICAL RESEARCH INC | Durham | — | $22.4M | 4 |
| Pine Lake Preparatory | Mooresville | B29 Education | $22.3M | 5 |
| TELCO COMMUNITY CREDIT UNION | Candler | — | $22.2M | 5 |
| DHIC Inc | Raleigh | — | $22.1M | 9 |
| CAROMONT HEALTH SERVICES | Gastonia | E20 Health Care | $21.8M | 5 |
| MOUNTAIN CREDIT UNION | Waynesville | — | $21.8M | 7 |
| NEW HANOVER COUNTY FINANCING CORPORATION | Wilmington | W110 Public & Societal Benefit | $21.7M | 0 |
| NORTH CAROLINA CENTRAL UNIVERSITY FOUNDATION INC | Durham | B110 Education | $21.7M | 2 |
| HENDERSON COLLEGIATE INC | Henderson | B29 Education | $21.7M | 2 |
| CHRIST SCHOOL INC | Arden | B250 Education | $21.6M | 6 |
