| CONCERN FOR INDEPENDENT LIVING INC | Medford | F330 Mental Health & Crisis Intervention | $57.9M | 7 |
| WILLIAM J BRENNAN CENTER FOR | New York | B40Z Education | $57.9M | 12 |
| NYSARC INC - WESTCHESTER COUNTY CHAPTER | Hawthorne | P700 Human Services | $57.9M | 7 |
| ASTOR SERVICES FOR CHILDREN & FAMILIES | Rhinebeck | P300 Human Services | $57.6M | 9 |
| OZANAM HALL OF QUEENS NURSING HOME INC | Bayside | E91 Health Care | $57.4M | 6 |
| TEAMSTERS LOCAL 237 ADMINISTRATIVE FUND | New York | J40 Employment | $57.3M | 0 |
| ACCESSCNY INC | Syracuse | G23Z Diseases, Disorders & Medical Disciplines | $57.2M | 8 |
| RISEWELL COMMUNITY SERVICES INC FKA | West Babylon | — | $57.1M | 13 |
| GOODWILL OF THE FINGER LAKES INC | Rochester | P11 Human Services | $57M | 6 |
| VISITING NURSE SERVICE OF NEW YORK | New York | E92 Health Care | $56.9M | 7 |
| STANLEY FAMILY FOUNDATION | Briarcliff Manor | — | $56.6M | 0 |
| UNITED CEREBRAL PALSY ASSOCIATION | Hauppauge | G200 Diseases, Disorders & Medical Disciplines | $56.5M | 7 |
| LITTLE FLOWER CHILDREN FAMILY SERVICES | Wading River | P20 Human Services | $56.4M | 9 |
| ROCHESTER PREP CHARTER SCHOOLS | Rochester | B29 Education | $56.1M | 7 |
| THE BREARLEY SCHOOL | New York | B200 Education | $56.1M | 8 |
| LIVING RESOURCES CORPORATION | Albany | P73Z Human Services | $56.1M | 7 |
| Center for Disability Rights Inc | Rochester | R23Z Civil Rights, Social Action & Advocacy | $56.1M | 5 |
| RYE COUNTRY DAY SCHOOL | Rye | B200 Education | $56.1M | 9 |
| Parkinson's Foundation Inc | New York | H800 Medical Research | $56M | 14 |
| NYSARC INC ERIE COUNTY CHAPTER | Williamsville | P820 Human Services | $55.9M | 8 |
| AMER FED STATE COUNTY MUNI EMP AFL-CIO | New York | — | $55.9M | 56 |
| LEON LEVY FOUNDATION | New York | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $55.8M | 2 |
| FEGS HOME ATTENDANT SERVICES INC | Bronx | P44Z Human Services | $55.5M | 6 |
| GRACE CHURCH SCHOOL | New York | B24 Education | $55.4M | 8 |
| DOMINICAN UNIVERSITY NEW YORK | Orangeburg | — | $55.3M | 9 |
| Livewell Health And Welfare Plan | New Hyde Park | Y43 Mutual & Membership Benefit | $55.2M | 0 |
| SOLDIERS & SAILORS MEMORIAL HOSPITAL OF | Penn Yan | E220 Health Care | $54.9M | 17 |
| ROBERTS WESLEYAN UNIVERSITY | Rochester | B430 Education | $54.8M | 12 |
| GREATCARE INC | New York | P80 Human Services | $54.7M | 2 |
| IRI INNOVATIVE RESOURCES FOR | Elmont | P82Z Human Services | $54.7M | 7 |
| JAWONIO INC | New City | P800 Human Services | $54.5M | 8 |
| THE SHUBERT FOUNDATION INC | New York | — | $54.5M | 2 |
| EGER HEALTH CARE AND REHABILITATION | Staten Island | E91 Health Care | $54.2M | 9 |
| EPILEPSY-PRALID INC | Rochester | P82Z Human Services | $54.2M | 7 |
| BROOKVILLE CENTER FOR CHILDRENS SERVICES INC | Brookville | P20 Human Services | $54.1M | 6 |
| NEW YORK HISTORICAL SOCIETY | New York | A800 Arts, Culture & Humanities | $54M | 13 |
| NYSARC INC | Rochester | F330 Mental Health & Crisis Intervention | $53.9M | 9 |
| THE POPULATION COUNCIL INC | New York | Q055 International, Foreign Affairs & National Security | $53.8M | 12 |
| BronxCare Dr Martin Luther King JrHealth Center | Bronx | — | $53.7M | 8 |
| KEUKA COLLEGE | Keuka Park | B420 Education | $53.6M | 10 |
| The MetLife VEBA Trust | New York | — | $53.5M | 0 |
| HENRY STREET SETTLEMENT | New York | P280 Human Services | $53.3M | 7 |
| ACUMEN FUND INC | New York | Q123 International, Foreign Affairs & National Security | $53.2M | 15 |
| UPSTATE NEW YORK ENGINEERS HEALTH FUND | Syracuse | — | $53.2M | 1 |
| PUBLIC PREP CHARTER SCHOOL ACADEMIES | Bronx | B29 Education | $53.2M | 6 |
| AIZER HEALTH INC | Monroe | P20 Human Services | $53.2M | 8 |
| DREAM CHARTER SCHOOL | New York | B29 Education | $53.1M | 5 |
| Miriam Osborn Memorial Home Association | Rye | — | $53M | 13 |
| TEACH FOR ALL INC | New York | B99 Education | $53M | 14 |
| SAY YES BUFFALO SCHOLARSHIP INC | Buffalo | B12 Education | $53M | 10 |
