| Yale University | New Haven | B430 Education | $6.8B | 24 |
| YALE NEW HAVEN HOSPITAL | New Haven | E220 Health Care | $4.6B | 17 |
| KNIGHTS OF COLUMBUS | New Haven | Y41 Mutual & Membership Benefit | $2.8B | 36 |
| Hartford Hospital | Hartford | E220 Health Care | $2.7B | 22 |
| AMERICARES FOUNDATION INC | Stamford | Q123 International, Foreign Affairs & National Security | $2B | 13 |
| Boehringer Ingelheim Cares Foundation Inc | Ridgefield | B99 Education | $1.7B | 0 |
| YALE NEW HAVEN HEALTH SERVICES CORPORATION | New Haven | E120 Health Care | $1.1B | 30 |
| Save The Children Federation Inc | Fairfield | Q330 International, Foreign Affairs & National Security | $920.5M | 25 |
| GENERAL ELECTRIC INSURANCE PLAN TRUST | Norwalk | — | $913.9M | 0 |
| BRIDGEPORT HOSPITAL | Bridgeport | E220 Health Care | $910M | 14 |
| The Danbury Hospital | Danbury | E220 Health Care | $903.8M | 17 |
| SAINT FRANCIS HOSPITAL AND MEDICAL CENTER | Hartford | E220 Health Care | $876.8M | 17 |
| The Stamford Hospital | Stamford | E220 Health Care | $852.4M | 14 |
| DALIO FAMILY FUND INC | Westport | P20 Human Services | $806.9M | 0 |
| The Hospital of Central Connecticut | New Britain | E22 Health Care | $776.5M | 15 |
| Hartford HealthCare Corporation | Hartford | E210 Health Care | $707.6M | 44 |
| Hartford HealthCare Medical Group Specialists PLLC | Wethersfield | F31 Mental Health & Crisis Intervention | $694.9M | 14 |
| NORTHEAST MEDICAL GROUP INC | Stratford | — | $647M | 8 |
| SVMC Holdings Inc | Bridgeport | E20 Health Care | $637.9M | 15 |
| CONNECTICUT CHILDREN'S MEDICAL CENTER | Hartford | E240 Health Care | $637.6M | 18 |
| QUINNIPIAC UNIVERSITY | Hamden | B430 Education | $595.3M | 8 |
| The William W Backus Hospital | Norwich | E220 Health Care | $585.2M | 18 |
| GREENWICH HOSPITAL | Greenwich | E220 Health Care | $575.8M | 16 |
| SACRED HEART UNIVERSITY INCORPORATED | Fairfield | B430 Education | $540M | 13 |
| MIDDLESEX HOSPITAL | Middletown | E220 Health Care | $539.7M | 18 |
| LAWRENCE MEMORIAL HOSPITAL INC | New London | E220 Health Care | $501.4M | 10 |
| Fairfield University | Fairfield | B430 Education | $489.3M | 12 |
| THE ZOOM FOUNDATION | Greenwich | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $450.4M | 0 |
| WESLEYAN UNIVERSITY | Middletown | B420 Education | $449M | 19 |
| Midstate Medical Center | Meriden | E220 Health Care | $443.4M | 15 |
| The Norwalk Hospital Association | Norwalk | E220 Health Care | $433.1M | 15 |
| Nuvance Health Medical Practice CT Inc | Danbury | — | $423.7M | 22 |
| University of New Haven | West Haven | B430 Education | $379.7M | 13 |
| SAINT MARY'S HOSPITAL INC | Hartford | E220 Health Care | $355.8M | 15 |
| THE MERCY HOSPITAL INC | Hartford | E220 Health Care | $337.4M | 18 |
| TRINITY HEALTH OF NEW ENGLAND PROVIDER NETWORK ORGANIZATION INC | Hartford | — | $290.1M | 24 |
| UNIVERSITY OF HARTFORD | West Hartford | B430 Education | $287.5M | 22 |
| TRINITY COLLEGE | Hartford | B420 Education | $272.9M | 10 |
| GRIFFIN HOSPITAL | Derby | E220 Health Care | $268.3M | 13 |
| Stamford Health Medical Group Inc | Stamford | E30 Health Care | $251.5M | 24 |
| Hartford HealthCare Medical Group Inc | Wethersfield | E21 Health Care | $223.7M | 19 |
| The Charlotte Hungerford Hospital | Torrington | E220 Health Care | $217M | 14 |
| TRINITY HEALTH OF NEW ENGLAND CORPORATION INC | Hartford | E21Z Health Care | $205.4M | 15 |
| CONNECTICUT COLLEGE | New London | B420 Education | $191.8M | 11 |
| ACHIEVEMENT FIRST BROOKLYN CHARTER SCHOOLS C/O ACHIEVEMENT FIRST INC | New Haven | B29 Education | $190.4M | 5 |
| Yale University Retiree Health Benefits Coverage Trust | New Haven | Y430 Mutual & Membership Benefit | $182.8M | 0 |
| AREA COOPERATIVE EDUCATIONAL SERVICES | New Haven | B20 Education | $182M | 7 |
| COMMUNITY HEALTH CENTER INC | Middletown | E32 Health Care | $179.5M | 15 |
| BRISTOL HOSPITAL INC | Bristol | E220 Health Care | $175.2M | 11 |
| THE COMMON FUND FOR NONPROFIT ORGANIZATIONS | Wilton | S500 Community Improvement & Capacity Building | $173.6M | 18 |
