| 21ST CENTURY CYBER CHARTER SCHOOL | West Chester | B25 Education | $22.9M | 8 |
| LOYAL CHRISTIAN BENEFIT ASSOCIATION | Erie | — | $22.9M | 15 |
| INGLIS FOUNDATION | Philadelphia | P112 Human Services | $22.8M | 10 |
| THE JACK BUNCHER FOUNDATION | Pittsburgh | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $22.8M | 0 |
| UNITED DISABILITIES SERVICES | Lancaster | G23Z Diseases, Disorders & Medical Disciplines | $22.8M | 7 |
| CORNERSTONE CARE INC | Greensboro | E32Z Health Care | $22.8M | 7 |
| USW DISTRICT 10 LOCAL 286 HEALTH AND WELFARE FUND | Philadelphia | — | $22.8M | 4 |
| SHEET METAL WORKERS LOCAL NO 12 WELFARE FUND | Pittsburgh | — | $22.7M | 0 |
| Presbyterian Medical Center of Oakmont Pennsylvania Inc | Oakmont | E910 Health Care | $22.7M | 3 |
| PATHWAYS TO HOUSING - PA | Philadelphia | L20 Housing & Shelter | $22.7M | 7 |
| SECOND HARVEST FOOD BANK OF NW PA INC | Erie | K31Z Food, Agriculture & Nutrition | $22.6M | 1 |
| WISSAHICKON HOSPICE OF UPHS | Bala Cynwyd | P74Z Human Services | $22.6M | 17 |
| COMMUNITY FIRST FUND | Lancaster | L80Z Housing & Shelter | $22.6M | 6 |
| COMMUNITY RESOURCES FOR INDEPENDENCE INC | Erie | — | $22.6M | 5 |
| PHILADELPHIA COLLEGE OF OSTEOPATHIC MEDICINE FOUNDATION | Philadelphia | B110 Education | $22.6M | 8 |
| DAYSPRING CHRISTIAN ACADEMY | Mountville | B20 Education | $22.5M | 3 |
| NATIONAL CONSTITUTION CENTER | Philadelphia | A540 Arts, Culture & Humanities | $22.5M | 8 |
| LABORERS' DISTRICT COUNCIL EDUCATION & TRAINING FUND OF THE PHILADELPHIA AREA | Exton | B30 Education | $22.5M | 1 |
| GLADE RUN LUTHERAN SERVICES | Zelienople | P300 Human Services | $22.5M | 5 |
| THE ACADEMY OF NATURAL SCIENCES OF PHILADELPHIA | Philadelphia | U300 Science & Technology | $22.4M | 14 |
| STAIRWAYS BEHAVIORAL HEALTH INC | Erie | F300 Mental Health & Crisis Intervention | $22.4M | 9 |
| MERAKEY PARKSIDE RECOVERY | Lafayette Hill | — | $22.3M | 8 |
| JOHN HEINZ INSTITUTE OF REHABILITATION MEDICINE | Clarks Summit | E50Z Health Care | $22.3M | 5 |
| COUNCIL OF THREE RIVERS AMERICAN INDIAN CENTER INC | Pittsburgh | P800 Human Services | $22.1M | 8 |
| Brandywine Conservancy & Museum of Art | Chadds Ford | A500 Arts, Culture & Humanities | $22M | 7 |
| Christ the King Manor Inc | DuBois | E91Z Health Care | $22M | 3 |
| PEIRCE COLLEGE | Philadelphia | — | $22M | 12 |
| HISTORICAL SOCIETY OF WESTERN PENNSYLVANIA | Pittsburgh | A800 Arts, Culture & Humanities | $22M | 5 |
| TUSCARORA INTERMEDIATE UNIT CAPITAL INSURANCE TRUST | Pleasant Gap | — | $21.8M | 0 |
| PENNSYLVANIA SCHOOL FOR THE DEAF | Philadelphia | — | $21.8M | 7 |
| SQUARE ROOTS COMMUNITY PARTNERSHIP INC | Kennett Square | — | $21.8M | 3 |
| VALLEY VIEW HAVEN INC DBA VALLEY VIEW RETIREMENT COMMUNITY | Belleville | L20 Housing & Shelter | $21.8M | 8 |
| KIDSPEACE NATIONAL CENTERS OF NORTH AMERICA | Schnecksville | — | $21.8M | 6 |
| MERCY MANAGEMENT OF SOUTHEASTERN PENNSYLVANIA | Newtown Square | E21Z Health Care | $21.8M | 11 |
| The Vanguard Group Foundation | Malvern | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $21.7M | 0 |
| MATERNAL & FAMILY HEALTH SERVICES INC | Wilkes Barre | E40Z Health Care | $21.7M | 5 |
| ELM TERRACE GARDENS | Lansdale | P750 Human Services | $21.6M | 7 |
| THE DA VINCI DISCOVERY CENTER OF SCIENCE AND TECHNOLOGY INC | Allentown | A52 Arts, Culture & Humanities | $21.6M | 5 |
| DON SERVICES INC | New Castle | P50 Human Services | $21.6M | 6 |
| BEHAVIORAL HEALTH ASSOCIATES | Weissport | F60 Mental Health & Crisis Intervention | $21.6M | 9 |
| SOLEBURY SCHOOL | New Hope | — | $21.5M | 7 |
| HATFIELD MENNONITE HOME INC | Hatfield | E91Z Health Care | $21.5M | 8 |
| VISIONCORPS | Lancaster | P860 Human Services | $21.5M | 10 |
| CRISTO REY PHILADELPHIA HIGH SCHOOL | Philadelphia | B25 Education | $21.5M | 3 |
| THE NEUBAUER FAMILY FOUNDATION | Philadelphia | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $21.4M | 1 |
| SCHUYLKILL COUNTY EMPLOYEES HEALTH & WELFARE TRUST | Mar Lin | — | $21.4M | 0 |
| DIVERSIFIED CARE MANAGEMENT | Cranberry Township | P20 Human Services | $21.4M | 1 |
| CHILD GUIDANCE RESOURCE CENTERS | Havertown | F300 Mental Health & Crisis Intervention | $21.4M | 7 |
| GREENBERG FOUNDATION C/O IRENE FIELDS | Equinunk | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $21.4M | 0 |
| THE BRADLEY CENTER INC | Pittsburgh | P820 Human Services | $21.3M | 10 |
