| GLADE RUN LUTHERAN SERVICES | Zelienople | P300 Human Services | $22.5M | 5 |
| NUTRITIONAL DEVELOPMENT SERVICES | Philadelphia | — | $22.4M | 3 |
| WILLIAMSON COLLEGE OF THE TRADES | Media | B300 Education | $22.4M | 5 |
| STAIRWAYS BEHAVIORAL HEALTH INC | Erie | F300 Mental Health & Crisis Intervention | $22.4M | 9 |
| CP 2023 | Philadelphia | A11 Arts, Culture & Humanities | $22.2M | 0 |
| Brandywine Conservancy & Museum of Art | Chadds Ford | A500 Arts, Culture & Humanities | $22M | 7 |
| COUNCIL OF THREE RIVERS AMERICAN INDIAN CENTER INC | Pittsburgh | P800 Human Services | $22M | 8 |
| Christ the King Manor Inc | DuBois | E91Z Health Care | $22M | 3 |
| PEIRCE COLLEGE | Philadelphia | — | $22M | 12 |
| HISTORICAL SOCIETY OF WESTERN PENNSYLVANIA | Pittsburgh | A800 Arts, Culture & Humanities | $22M | 5 |
| THE JACK BUNCHER FOUNDATION | Pittsburgh | — | $21.9M | 0 |
| THE ACADEMY OF NATURAL SCIENCES OF PHILADELPHIA | Philadelphia | U300 Science & Technology | $21.9M | 14 |
| PENNSYLVANIA SCHOOL FOR THE DEAF | Philadelphia | — | $21.8M | 7 |
| JOHN HEINZ INSTITUTE OF REHABILITATION MEDICINE | Clarks Summit | E50Z Health Care | $21.8M | 6 |
| SQUARE ROOTS COMMUNITY PARTNERSHIP INC | Kennett Square | — | $21.8M | 3 |
| KIDSPEACE NATIONAL CENTERS OF NORTH AMERICA | Schnecksville | — | $21.8M | 6 |
| Esperanza Cyber Charter School | Philadelphia | B29 Education | $21.8M | 2 |
| The Vanguard Group Foundation | Malvern | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $21.7M | 0 |
| MATERNAL & FAMILY HEALTH SERVICES INC | Wilkes Barre | E40Z Health Care | $21.7M | 5 |
| THE NEAG FOUNDATION | Wyomissing | — | $21.7M | 3 |
| MADLYN AND LEONARD ABRAMSON CENTER FOR JEWISH LIFE AND SUBSIDIARIES | Jenkintown | E91 Health Care | $21.7M | 11 |
| THE DA VINCI DISCOVERY CENTER OF SCIENCE AND TECHNOLOGY INC | Allentown | A52 Arts, Culture & Humanities | $21.6M | 5 |
| BEHAVIORAL HEALTH ASSOCIATES | Weissport | F60 Mental Health & Crisis Intervention | $21.6M | 9 |
| SOLEBURY SCHOOL | New Hope | — | $21.5M | 7 |
| OHIO STATE PLUMBERS & PIPEFITTERS HEALTH AND WELFARE FUND | Harmony | — | $21.5M | 0 |
| VISIONCORPS | Lancaster | P860 Human Services | $21.5M | 10 |
| THE NEUBAUER FAMILY FOUNDATION | Philadelphia | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $21.4M | 1 |
| MAPLE HEALTH AND REHABILITATION CENTERS INC | Bala Cynwyd | L22 Housing & Shelter | $21.4M | 8 |
| DIVERSIFIED CARE MANAGEMENT | Cranberry Township | P20 Human Services | $21.4M | 1 |
| CHANDLER HALL HEALTH SERVICES INC | Newtown | E210 Health Care | $21.4M | 8 |
| GREENBERG FOUNDATION C/O IRENE FIELDS | Equinunk | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $21.4M | 0 |
| EASTERN ATLANTIC STATES CARPENTERS TECHNICAL CENTERS | Philadelphia | J22Z Employment | $21.3M | 8 |
| BERKS COMMUNITY HEALTH CENTER | Reading | E32 Health Care | $21.3M | 7 |
| OLD MAN'S HOME OF PHILADELPHIA D/B/A SAUNDERS HOUSE | Collegeville | P750 Human Services | $21.3M | 1 |
| PHILADELPHIA YOUTH NETWORK INC | Philadelphia | O02 Youth Development | $21.2M | 5 |
| HATFIELD MENNONITE HOME INC | Hatfield | E91Z Health Care | $21.2M | 5 |
| NATIONAL KITCHEN & BATH ASSOCIATION | Bethlehem | — | $21.1M | 11 |
| ROSEMONT COLLEGE | Rosemont | B42Z Education | $21.1M | 7 |
| ENERGY COORDINATING AGENCY OF PHILADELPHIA INC | Philadelhia | L820 Housing & Shelter | $21.1M | 3 |
| CRISTO REY PHILADELPHIA HIGH SCHOOL | Philadelphia | B25 Education | $21M | 5 |
| Holy Family Senior Living | Bethlehem | — | $20.9M | 2 |
| West Oak Lane Charter School | Philadelphia | B290 Education | $20.9M | 9 |
| ASBURY HEALTH CENTER | Pittsburgh | P750 Human Services | $20.9M | 7 |
| JACK M BARRACK HEBREW ACADEMY | Bryn Mawr | — | $20.9M | 6 |
| LANCASTER EMERGENCY MEDICAL SERVICES ASSOCIATION | Lancaster | E62 Health Care | $20.8M | 8 |
| University City Science Center | Philadelphia | U050 Science & Technology | $20.8M | 12 |
| VERLAND CLA | Sewickley | P73Z Human Services | $20.8M | 4 |
| COMMUNITY FOUNDATION OF WESTERN PENNSYLVANIA AND EASTERN OHIO | Sharon | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $20.8M | 2 |
| PHOEBE RICHLAND HEALTH CARE CENTER INC | Allentown | E910 Health Care | $20.7M | 8 |
| EMERGYCARE INC | Erie | E62Z Health Care | $20.6M | 3 |
