| THE CHAMPLIN FOUNDATION | Pittsburgh | — | $23.8M | 11 |
| OBERKOTTER FOUNDATION | Philadelphia | — | $23.6M | 5 |
| INDIAN CREEK FOUNDATION | Souderton | F70 Mental Health & Crisis Intervention | $23.6M | 4 |
| AGENCY FOR COMMUNITY EMPOWERMENT OF NEPA | Scranton | P200 Human Services | $23.6M | 1 |
| SEWICKLEY ACADEMY | Sewickley | B200 Education | $23.5M | 7 |
| ACHIEVEMENT HOUSE CHARTER SCHOOL | Exton | B29 Education | $23.5M | 4 |
| COLCOM FOUNDATION | Pittsburgh | T70J Philanthropy, Voluntarism & Grantmaking Foundations | $23.5M | 14 |
| UNITED WAY OF THE GREATER LEHIGH VALLEY | Allentown | T70 Philanthropy, Voluntarism & Grantmaking Foundations | $23.5M | 8 |
| PHILADELPHIA CONVENTION & VISITORS | Philadelphia | — | $23.4M | 7 |
| VALLEY RURAL ELECTRIC COOPERATIVE INC | Huntingdon | — | $23.4M | 17 |
| THE EDUCATION CENTER AT THE WATSON | Sewickley | B280 Education | $23.4M | 6 |
| ELM TERRACE GARDENS | Lansdale | P750 Human Services | $23.4M | 7 |
| FREIRE CHARTER SCHOOL | Philadelphia | B24 Education | $23.3M | 2 |
| CONGRESO DE LATINOS UNIDOS INC | Philadelphia | E30Z Health Care | $23.3M | 8 |
| FRANKLIN TOWNE CHARTER HIGH SCHOOL | Philadelphia | B20 Education | $23.3M | 7 |
| ESPERANZA HEALTH CENTER INC | Philadelphia | E320 Health Care | $23.3M | 11 |
| VALLEY FORGE MILITARY ACADEMY FOUNDATION | Wayne | B250 Education | $23.2M | 3 |
| PITTSBURGH LIFETIME CARE COMMUNITY | Cranberry Twp | P750 Human Services | $23.2M | 9 |
| United Way of Greater Philadelphia and | Philadelphia | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $23.2M | 12 |
| LAKESHORE COMMUNITY SERVICES INC | Erie | P20Z Human Services | $23.2M | 8 |
| BELMONT CHARTER SCHOOL | Philadelphia | B29 Education | $23.1M | 6 |
| MASTERY CHARTER SCHOOL - PICKETT CAMPUS | Philadelphia | B20 Education | $23.1M | 6 |
| NORTHWESTERN RURAL ELECTRIC COOPERATIVE | Cambridge Springs | — | $23.1M | 19 |
| CONCORDIA LUTHERAN MINISTRIESFOUNDATION | Cabot | E11 Health Care | $23.1M | 7 |
| VEBA FOR RETIREES OF KAISER ALUMINUM | Pittsburgh | Y43 Mutual & Membership Benefit | $23.1M | 0 |
| The Comcast NBCUniversal Foundation | Philadelphia | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $23.1M | 0 |
| Tacony Academy Charter School | Philadelphia | B29 Education | $23.1M | 7 |
| MILESTONE CENTERS INC | Pittsburgh | F320 Mental Health & Crisis Intervention | $23M | 3 |
| BETHESDA MISSION OF HARRISBURG INC | Harrisburg | P280 Human Services | $23M | 1 |
| ARTMAN LUTHERAN HOME | Ambler | P750 Human Services | $22.9M | 9 |
| 21ST CENTURY CYBER CHARTER SCHOOL | West Chester | B25 Education | $22.9M | 8 |
| ASPIRA BILINGUAL CYBER CHARTER SCHOOL | Philadelphia | B29 Education | $22.9M | 2 |
| LOYAL CHRISTIAN BENEFIT ASSOCIATION | Erie | — | $22.9M | 15 |
| UNITED DISABILITIES SERVICES | Lancaster | G23Z Diseases, Disorders & Medical Disciplines | $22.8M | 7 |
| DELTA DENTAL OF WEST VIRGINIA INC | Camp Hill | — | $22.8M | 16 |
| ENDLESS MOUNTAINS HEALTH SYSTEMS INC | Montrose | E220 Health Care | $22.8M | 8 |
| CORNERSTONE CARE INC | Greensboro | E32Z Health Care | $22.8M | 7 |
| USW DISTRICT 10 LOCAL 286 | Philadelphia | — | $22.8M | 4 |
| ALYESKA PIPELINE WELFARE BENEFIT TRUST | Pittsburgh | — | $22.7M | 1 |
| PHILADELPHIA CHARTER SCHOOL FOR ARTS AND | Philadelphia | B20 Education | $22.7M | 2 |
| SHARING EXCESS | Philadelphia | K30 Food, Agriculture & Nutrition | $22.7M | 2 |
| SHEET METAL WORKERS LOCAL NO 12 WELFARE FUND | Pittsburgh | — | $22.7M | 0 |
| DR GERTRUDE A BARBER IN HOME | Erie | P20 Human Services | $22.7M | 6 |
| Presbyterian Medical Center of Oakmont | Oakmont | E910 Health Care | $22.7M | 3 |
| THE BRADLEY CENTER INC | Pittsburgh | P820 Human Services | $22.6M | 10 |
| NATIONAL CONSTITUTION CENTER | Philadelphia | A540 Arts, Culture & Humanities | $22.5M | 8 |
| TUSCARORA INTERMEDIATE UNIT CAPITAL | Pleasant Gap | — | $22.5M | 0 |
| LABORERS' DISTRICT COUNCIL EDUCATION & | Exton | B30 Education | $22.5M | 1 |
| DON SERVICES INC | New Castle | P50 Human Services | $22.5M | 3 |
| PENN MEDICINE-PMA | Philadelphia | E31 Health Care | $22.5M | 6 |
