| Coastal Medical Physicians Inc Brown University Health Primary Care | Providence | E21 Health Care | $41.4M | 19 |
| CHILDREN'S FRIEND AND SERVICE | Providence | P34Z Human Services | $40.8M | 5 |
| AMERICAN MATHEMATICAL SOCIETY | Providence | U030 Science & Technology | $39.9M | 12 |
| TRI-COUNTY COMMUNITY ACTION AGENCY | Johnston | P200 Human Services | $39.4M | 5 |
| UNIVERSITY OF RHODE ISLAND FOUNDATION & ALUMNI ENGAGEMENT | Kingston | B110 Education | $39.1M | 8 |
| FELLOWSHIP HEALTH RESOURCES INC | Lincoln | P820 Human Services | $38.9M | 11 |
| LOOKING UPWARDS INC | Middletown | P73Z Human Services | $36.6M | 7 |
| People's Credit Union | Middletown | — | $35M | 20 |
| PROVIDENCE PERFORMING ARTS CENTER | Providence | A610 Arts, Culture & Humanities | $34.1M | 8 |
| THE ACT FOUNDATION | Warwick | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $33.7M | 1 |
| THE PRESERVATION SOCIETY OF NEWPORT COUNTY | Newport | A800 Arts, Culture & Humanities | $33.7M | 7 |
| RHODE ISLAND COMMUNITY FOOD BANK ASSOCIATION | Providence | K31Z Food, Agriculture & Nutrition | $32.8M | 7 |
| INTERNATIONAL TENNIS HALL OF FAME INCORPORATED | Newport | N660 Recreation & Sports | $32.7M | 7 |
| Gateway Healthcare Inc | Providence | F22 Mental Health & Crisis Intervention | $32.3M | 16 |
| J ARTHUR TRUDEAU MEMORIAL CENTER | Warwick | — | $32M | 5 |
| Blackstone Valley Community Health Care Inc | Pawtucket | E300 Health Care | $29.7M | 13 |
| THRIVE BEHAVIORAL HEALTH INC | Warwick | F32Z Mental Health & Crisis Intervention | $29.6M | 9 |
| GODLEY FAMILY FOUNDATION | Saunderstown | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $28.8M | 1 |
| FAMILY SERVICE OF RHODE ISLAND INC | Providence | P30Z Human Services | $28.7M | 8 |
| WEST BAY RESIDENTIAL SERVICES | Warwick | P73Z Human Services | $28.3M | 2 |
| ROGER WILLIAMS UNIVERSITY SCHOOL OF LAW | Bristol | B53Z Education | $27M | 10 |
| UNITED WAY OF RHODE ISLAND INC | Providence | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $26.7M | 8 |
| WESTERLY COMMUNITY CREDIT UNION | Wakefield | — | $25.8M | 24 |
| NORTHWEST COMMUNITY HEALTH CARE | Pascoag | E99 Health Care | $25.2M | 9 |
| SAINT ELIZABETH HOME EAST GREENWICH | East Greenwich | — | $24.6M | 8 |
| BROWN UROLOGY INC | Providence | E20 Health Care | $24.4M | 11 |
| CROSSROADS RHODE ISLAND | Providence | P85Z Human Services | $24.2M | 12 |
| AMERICAN ACADEMY OF ADDICTION PSYCHIATRY INC | East Providence | G9XZ Diseases, Disorders & Medical Disciplines | $24.1M | 5 |
| Meeting Street | Providence | E500 Health Care | $24.1M | 8 |
| Lifespan School Solutions Inc dba The Bradley School | Providence | B28 Education | $24M | 11 |
| RHODE ISLAND CREDIT UNION | Providence | — | $22.2M | 19 |
| SKILLS FOR RHODE ISLAND'S FUTURE | Providence | J22 Employment | $21.9M | 6 |
| THE COLLIS FOUNDATION | Providence | T22J Philanthropy, Voluntarism & Grantmaking Foundations | $21.9M | 0 |
| SAINT ANTOINE RESIDENCE | North Smithfield | P750 Human Services | $21.8M | 11 |
| REFOCUS INC | Providence | F34Z Mental Health & Crisis Intervention | $21.7M | 8 |
| Southeastern New England Defense Industry Alliance | Middletown | S40 Community Improvement & Capacity Building | $21.6M | 1 |
| CODAC INC | Cranston | F22 Mental Health & Crisis Intervention | $21.3M | 6 |
| NEWPORT COUNTY COMMUNITY MENTAL HEALTH CENTER INC | Middletown | F34Z Mental Health & Crisis Intervention | $21.1M | 8 |
| NORTH AMERICAN CATHOLIC EDUCATIONAL PROGRAMMING FOUNDATION INC | Johnston | X800 Religion-Related | $20.8M | 4 |
| THE GRODEN CENTER INC | Providence | — | $20.7M | 7 |
| LINCOLN SCHOOL | Providence | — | $20.4M | 7 |
| GREATER PROVIDENCE YOUNG MENS CHRISTIAN ASSOCIATION | Providence | P27Z Human Services | $20.2M | 6 |
| PAUL CUFFEE SCHOOL | Providence | B29 Education | $19.8M | 7 |
| WESTBAY COMMUNITY ACTION INC | Warwick | — | $19.5M | 4 |
| RALPH R PAPITTO & BARBARA A PAPITTO PRIVATE FAMILY FOUNDATION | Providence | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $19.5M | 3 |
| KENT COUNTY VISITING NURSE ASSOCIATION | Providence | E91Z Health Care | $19.4M | 14 |
| MICHIGAN AUTOMOBILE INSURANCE PLACEMENT FACILITY | Johnston | — | $18.9M | 9 |
| TOCKWOTTON HOME | East Providence | P750 Human Services | $18.7M | 7 |
| FACTORY MUTUAL INSURANCE COMPANY POSTRETIREMENT WELFARE PROGRAM | Johnston | — | $18.6M | 0 |
| JEWISH FEDERATION FOUNDATION OF GREATER RHODE ISLAND | Providence | T70 Philanthropy, Voluntarism & Grantmaking Foundations | $18.5M | 0 |
