| Barlow Respiratory Hospital | Los Angeles | E240 Health Care | $74.8M | 10 |
| KFH HOLDINGS INC | Oakland | E60 Health Care | $74.7M | 7 |
| CALIFORNIA POLYTECHNIC STATE UNIVERSITY FOUNDATION | San Luis Obispo | B11 Education | $74.7M | 5 |
| BY THE BAY Health | Larkspur | P74 Human Services | $74.7M | 13 |
| CRABILL FAMILY FOUNDATION | San Francisco | P20 Human Services | $74.1M | 0 |
| EDUCATION FOR CHANGE | Oakland | B29 Education | $74M | 8 |
| CREATIVE CENTER OF LOS ALTOS | Los Altos | B24Z Education | $73.7M | 11 |
| HOBSONLUCAS FAMILY FOUNDATION | San Rafael | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $73.5M | 0 |
| Woka Foundation | Newbury Park | X01 Religion-Related | $73.4M | 1 |
| Los Angeles County Fair Association | Pomona | — | $73.2M | 7 |
| Lake County Tribal Health Consortium Inc | Lakeport | Z99Z Unknown | $73.1M | 31 |
| ENTERTAINMENT INDUSTRY FOUNDATION | Los Angeles | T70Z Philanthropy, Voluntarism & Grantmaking Foundations | $72.9M | 9 |
| GOOD NEIGHBORS GLOBAL PARTNERSHIP CENTER | Tustin | Q33 International, Foreign Affairs & National Security | $72.9M | 1 |
| LIFELONG LEARNING ADMINISTRATION CORPORATION | Lancaster | B29 Education | $72.9M | 14 |
| SAN DIEGO HUMANE SOCIETY & SPCA | San Diego | D200 Animal-Related | $72.9M | 8 |
| VIEWPOINT EDUCATIONAL FOUNDATION | Calabasas | — | $72.8M | 10 |
| THE DAVID GEFFEN FOUNDATION | Los Angeles | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $72.8M | 1 |
| California Teaching Fellows Foundation | Fresno | — | $72.7M | 14 |
| CAMARENA HEALTH | Madera | E320 Health Care | $72.7M | 7 |
| THE WILLIAM JEFF AND JENNIFER GROSS FAMILY FOUNDATION | Laguna Beach | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $72.6M | 1 |
| SOUTHERN MONTEREY COUNTY MEMORIAL HOSPITAL | King City | — | $72.4M | 13 |
| MARIN COMMUNITY CLINIC | Novato | E70Z Health Care | $72.4M | 12 |
| Planned Parenthood Shasta-Diablo Inc | Concord | E420 Health Care | $72.4M | 9 |
| THE SOBRATO FAMILY FOUNDATION | Mountain View | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $72.2M | 0 |
| JOB OPTIONS INC | San Diego | J30 Employment | $72.2M | 32 |
| NATIONAL COMMUNITY RENAISSANCE OF CALIFORNIA | Rancho Cucamonga | L200 Housing & Shelter | $72M | 25 |
| SAN JOSE STATE UNIVERSITY RESEARCH FOUNDATION | San Jose | B110 Education | $71.9M | 22 |
| MOMENTUM FOR HEALTH | San Jose | F300 Mental Health & Crisis Intervention | $71.7M | 12 |
| La Sierra University | Riverside | B430 Education | $71.7M | 9 |
| METROPOLITAN EMPLOYEES BENEFITS ASSOCIATION | San Diego | — | $71.5M | 0 |
| AMERICAN YOUTH SOCCER ORGANIZATION | Torrance | N640 Recreation & Sports | $71.3M | 7 |
| TREVOR PROJECT INC | West Hollywood | R20 Civil Rights, Social Action & Advocacy | $71.2M | 13 |
| FEEDING AMERICA RIVERSIDE SAN BERNARDINO COUNTIES | Riverside | K31Z Food, Agriculture & Nutrition | $71.1M | 2 |
| PHILANTHROPIC VENTURES FOUNDATION | Oakland | T500 Philanthropy, Voluntarism & Grantmaking Foundations | $71M | 2 |
| RICHARD B FULLERTON FOUNDATION | San Francisco | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $70.9M | 0 |
| LA FAMILY HOUSING CORPORATION | North Hollywood | — | $70.7M | 20 |
| SHASTA COMMUNITY HEALTH CENTER | Redding | E32Z Health Care | $70.5M | 16 |
| Penny Lane Centers | North Hollywood | — | $70.5M | 7 |
| SAN FRANCISCO BALLET ASSOCIATION | San Francisco | A630 Arts, Culture & Humanities | $70.4M | 14 |
| GOLDEN GLOBE FOUNDATION | West Hollywood | A12 Arts, Culture & Humanities | $70.3M | 1 |
| Visa Foundation | San Francisco | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $70.2M | 0 |
| GALLO EMPLOYEE BENEFIT TRUST | Modesto | Z99 Unknown | $70M | 0 |
| THE AHMANSON FOUNDATION | Beverly Hills | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $70M | 3 |
| VAUGHN NEXT CENTURY LEARNING CENTER | San Fernando | B29 Education | $69.9M | 10 |
| WESTERN TEAMSTERS WELFARE TRUST | Pasadena | — | $69.7M | 0 |
| PRAGER UNIVERSITY FOUNDATION | Sherman Oaks | B99 Education | $69.7M | 11 |
| CAMBIAR EDUCATION | San Diego | B90 Education | $69.5M | 6 |
| BUCK INSTITUTE FOR RESEARCH ON AGING | Novato | V99 Social Science | $69.5M | 8 |
| SPAHT FAMILY FOUNDATION | San Francisco | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $69.5M | 0 |
| XQ INSTITUTE | Oakland | B90 Education | $69.4M | 3 |
