| MOZILLA FOUNDATION | San Francisco | U40 Science & Technology | $64.7M | 16 |
| CAMINO NUEVO CHARTER ACADEMY | Los Angeles | B29 Education | $64.5M | 6 |
| G4S SECURE SOLUTIONS (USA) GRP INSURANCE PROGRAM FOR EMPL & DEPS | Irvine | — | $64.4M | 0 |
| THE KOUM FAMILY FOUNDATION | Palo Alto | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $64.3M | 1 |
| DREW CHILD DEVELOPMENT CORPORATION | Gardena | P37Z Human Services | $64.2M | 5 |
| Operating Engineers Local 501 Security Fund | West Covina | — | $63.7M | 0 |
| THOUSAND CURRENTS | San Francisco | Q300 International, Foreign Affairs & National Security | $63.6M | 5 |
| PEDIATRIC AND FAMILY MEDICAL CENTER DBA EISNER HEALTH | Los Angeles | E220 Health Care | $63.5M | 14 |
| CALIFORNIA RURAL INDIAN HEALTH BOARD INC | Roseville | E39Z Health Care | $63.5M | 30 |
| BLUPEAK CREDIT UNION | San Diego | — | $63.5M | 13 |
| RIVERSIDE SHERIFFS ASSOCIATION BENEFIT TRUST | Riverside | — | $63.4M | 1 |
| QUALITY DEVELOPMENT AND CONSTRUCTION INC | Irvine | L11 Housing & Shelter | $63.4M | 12 |
| VALLEY FIRST CREDIT UNION | Modesto | — | $63.3M | 15 |
| PLEDGELING FOUNDATION | San Francisco | T12 Philanthropy, Voluntarism & Grantmaking Foundations | $63.2M | 3 |
| RADY CHILDREN'S HEALTH SERVICES - SAN DIEGO | San Diego | — | $63M | 15 |
| CALFOODS LOGISTICS | Pleasant Hill | K31 Food, Agriculture & Nutrition | $63M | 5 |
| SOUTHLAND CREDIT UNION | Los Alamitos | — | $62.8M | 8 |
| JEWISH FAMILY SERVICE OF LOS ANGELES | Los Angeles | P400 Human Services | $62.7M | 11 |
| JOHN ADAMS ACADEMIES INC | Roseville | B29 Education | $62.6M | 6 |
| MENLO COLLEGE | Atherton | — | $62.6M | 6 |
| REDWOOD EMPIRE FOOD BANK | Santa Rosa | K31Z Food, Agriculture & Nutrition | $62.6M | 10 |
| UDW AFSCME 3930 RIVERSIDE COUNTY BENEFITS TRUST FUND | San Diego | Y43 Mutual & Membership Benefit | $62.6M | 1 |
| COLLEGE TRACK | Oakland | B82 Education | $62.4M | 15 |
| NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION INC | San Francisco | H00Z Medical Research | $62.3M | 7 |
| CATHOLIC CHARITIES CYO OF THE ARCHDIOCESE OF SAN FRANCISCO | San Francisco | P20Z Human Services | $62.3M | 9 |
| Unlikely Collaborators Inc | West Hollywood | T99 Philanthropy, Voluntarism & Grantmaking Foundations | $62.1M | 0 |
| ARARAT HOME OF LOS ANGELES | Mission Hills | E910 Health Care | $62M | 5 |
| JEFF AND MARIEKE ROTHSCHILD FOUNDATION | Palo Alto | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $62M | 0 |
| SOCIAL GOOD FUND INC | Richmond | B99 Education | $62M | 9 |
| EDNOVATE INC | Los Angeles | B20 Education | $62M | 10 |
| THE EAMES INSTITUTE | Petaluma | A54 Arts, Culture & Humanities | $61.9M | 6 |
| WESTERN ALLIANCE TRUST FUND | Pasadena | — | $61.8M | 0 |
| UNITED INDIAN HEALTH SERVICES INC | Arcata | E320 Health Care | $61.7M | 27 |
| Illumination Health Home formerly The Illumination Foundation | Santa Ana | P85 Human Services | $61.6M | 5 |
| UNITED TEACHERS LOS ANGELES | Los Angeles | — | $61.5M | 14 |
| THE CAMPANILE FOUNDATION | San Diego | B110 Education | $61.5M | 5 |
| SEIU LOCAL 1021 | Oakland | — | $61.4M | 49 |
| COMMUNITY HEALTH SYSTEMS INC | Riverside | — | $61.4M | 12 |
| SKID ROW HOUSING TRUST | Los Angeles | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $61.2M | 3 |
| Pathways LA | Los Angeles | P330 Human Services | $61.2M | 6 |
| VALLEY HEALTH TEAM INC | San Joaquin | E30Z Health Care | $61M | 5 |
| CAL POLY HUMBOLDT SPONSORED PROGRAMS FOUNDATION | Arcata | B43I Education | $61M | 27 |
| CYPRESS LAWN CEMETERY ASSOCIATION | Colma | — | $61M | 17 |
| THE DEUTSCH FOUNDATION | Santa Monica | T22J Philanthropy, Voluntarism & Grantmaking Foundations | $60.9M | 1 |
| SBCS CORPORATION | Chula Vista | P200 Human Services | $60.8M | 9 |
| LifeStream Blood Bank | San Bernardino | E61 Health Care | $60.7M | 7 |
| KAISER HEALTH PLAN ASSET MANAGEMENT INC | Oakland | E110 Health Care | $60.7M | 10 |
| THE INTERNATIONAL SCHOOL OF SAN FRANCISCO | San Francisco | B26Z Education | $60.6M | 8 |
| WONDERFUL COLLEGE PREP ACADEMY | Delano | B29 Education | $60.6M | 8 |
| 1ST UNITED CREDIT UNION | Pleasanton | — | $60.5M | 25 |
