| SCHUMAN FAMILY FOUNDATION | Beverly Hills | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $53.1M | 0 |
| Central City Community Health Center Inc | Monterey Park | Z99 Unknown | $53M | 9 |
| TOLD FOUNDATION | Camarillo | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $53M | 0 |
| CAPITAL GROUP COMPANIES CHARITABLE FOUNDATION | Irvine | T20Z Philanthropy, Voluntarism & Grantmaking Foundations | $52.7M | 0 |
| REVOLUTIONARY MEDICAL TRUST | Pasadena | — | $52.6M | 0 |
| TOSA FOUNDATION C/O TASHIA MORGRIDGE | Portola Valley | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $52.6M | 1 |
| CAMINAR | San Mateo | F31Z Mental Health & Crisis Intervention | $52.5M | 18 |
| HOPE SERVICES | San Jose | J300 Employment | $52.4M | 9 |
| KINGS COMMUNITY ACTION ORGANIZATION INC | Hanford | P20Z Human Services | $52.3M | 6 |
| DESERT SANDS PUBLIC CHARTER INC | Valencia | B29 Education | $52.2M | 16 |
| CHILDREN'S HEALTHCARE OF CALIFORNIA | Orange | E120 Health Care | $52.1M | 5 |
| THE LOS ANGELES FREE CLINIC | Los Angeles | E32Z Health Care | $52.1M | 7 |
| CLINICA MSR OSCAR A ROMERO | Los Angeles | E32Z Health Care | $52.1M | 10 |
| CALIFORNIA VIRTUAL ACADEMY SAN DIEGO | Simi Valley | B20 Education | $52.1M | 0 |
| WOODBURY UNIVERSITY | Burbank | B430 Education | $52.1M | 15 |
| THE MARISLA FOUNDATION | Laguna Beach | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $52M | 3 |
| FOOD IN NEED OF DISTRIBUTION INC | Indio | K310 Food, Agriculture & Nutrition | $52M | 2 |
| CHRYSALIS CENTER | Los Angeles | — | $51.9M | 6 |
| MEN'S HEALTH FOUNDATION | Los Angeles | E30 Health Care | $51.8M | 11 |
| CENTER THEATRE GROUP OF LOS ANGELES | Los Angeles | A650 Arts, Culture & Humanities | $51.8M | 9 |
| SECOND HARVEST OF THE GREATER VALLEY | Manteca | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $51.7M | 1 |
| SPECIALTY EQUIPMENT MARKET ASSOCIATION & PERFORMANCE RACING INC | Diamond Bar | — | $51.6M | 11 |
| MONTAGE MEDICAL GROUP | Monterey | E30 Health Care | $51.5M | 10 |
| BAY AREA AUTOMOTIVE GROUP WELFARE FUND | Dublin | — | $51.5M | 0 |
| PISCES FOUNDATION | San Francisco | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $51.5M | 2 |
| REX AND MARGARET FORTUNE SCHOOL OF EDUCATION | Sacramento | B25 Education | $51.5M | 8 |
| EVERY ORG | San Francisco | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $51.4M | 3 |
| PRICE PHILANTHROPIES FOUNDATION | La Jolla | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $51.4M | 3 |
| FLEXTECH ALLIANCE INC | San Jose | — | $51.3M | 8 |
| GLOBAL SUPPORT AND DEVELOPMENT | Redwood City | P20 Human Services | $51.1M | 2 |
| MANIFEST MEDEX | Riverside | E02 Health Care | $51.1M | 11 |
| Gracelight Community Health | Los Angeles | — | $51M | 9 |
| UNIVERSITY FACULTY ASSOCIATES INC | Fresno | E21 Health Care | $51M | 0 |
| JONI AND FRIENDS | Agoura Hills | — | $50.9M | 9 |
| THE UNIVERSITY CORPORATION | Northridge | — | $50.7M | 14 |
| GOLDEN GATE NATIONAL PARKS CONSERVANCY | San Francisco | C110 Environment | $50.7M | 15 |
| ST JOSEPH CENTER | Venice | P200 Human Services | $50.4M | 9 |
| MIND OC | Irvine | P20 Human Services | $50.4M | 11 |
| COMMUNITY FOUNDATION SANTA CRUZ COUNTY | Aptos | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $50.4M | 5 |
| DREAM MACHINE INNOVATION SO INC | Los Angeles | S31 Community Improvement & Capacity Building | $50.4M | 2 |
| REAL JOURNEY ACADEMIES | Ontario | B29 Education | $50.4M | 7 |
| SOUTH CENTRAL FAMILY HEALTH CENTER | Los Angeles | E32Z Health Care | $50.2M | 12 |
| HILLSIDES | Pasadena | P200 Human Services | $50.2M | 10 |
| UFW FOUNDATION | Los Angeles | — | $50.1M | 7 |
| PROVIDENCE HEALTH & SERVICES FOUNDATION SAN FERNANDO & SANTA CLARITA VALLEYS SA | Burbank | E112 Health Care | $50.1M | 5 |
| ARIA COMMUNITY HEALTH CENTER | Lemoore | E30Z Health Care | $50M | 9 |
| CRAIG H NEILSEN FOUNDATION | Calabasas | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $50M | 7 |
| INTERNATIONAL RELIEF TEAMS | San Diego | Q330 International, Foreign Affairs & National Security | $50M | 2 |
| DISABILITY RIGHTS CALIFORNIA | Sacramento | R230 Civil Rights, Social Action & Advocacy | $49.7M | 7 |
| RADY CHILDREN'S HOSPITAL FOUNDATION - SAN DIEGO | San Diego | T11 Philanthropy, Voluntarism & Grantmaking Foundations | $49.7M | 13 |
