| TIBURCIO VASQUEZ HEALTH CENTER INC | Hayward | E320 Health Care | $47M | 5 |
| UNION OF CALIFORNIA STATE WORKERS | Sacramento | J40 Employment | $46.9M | 5 |
| ACACIA FOUNDATION | Arcadia | T99Z Philanthropy, Voluntarism & Grantmaking Foundations | $46.8M | 2 |
| GOLDEN GATE UNIVERSITY | San Francisco | B430 Education | $46.8M | 13 |
| STEP UP ON SECOND STREET INC | Santa Monica | P800 Human Services | $46.7M | 7 |
| UCSF HEALTH MEDICAL FOUNDATION | Emeryville | E112 Health Care | $46.7M | 14 |
| FOOD IN NEED OF DISTRIBUTION INC | Indio | K310 Food, Agriculture & Nutrition | $46.6M | 1 |
| LOS ANGELES OPERA COMPANY | Los Angeles | A6A0 Arts, Culture & Humanities | $46.6M | 13 |
| San Diego UNITE - HERE Health Fund | San Diego | — | $46.6M | 0 |
| CASA DE LAS CAMPANAS INC | San Diego | P750 Human Services | $46.4M | 7 |
| INGLEWOOD PARK CEMETERY | Inglewood | — | $46.4M | 23 |
| Native American Health Center Inc | Oakland | — | $46.3M | 16 |
| TIDES NETWORK | San Francisco | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $46.3M | 12 |
| INTEL RETIREE MEDICAL PLAN TRUST | Santa Clara | — | $46.3M | 0 |
| MENTAL HEALTH AMERICA OF LOS ANGELES | Long Beach | — | $46.3M | 9 |
| GRANITE MOUNTAIN CHARTER SCHOOL | Lucerne Valley | B29 Education | $46.3M | 7 |
| MADERA COMMUNITY HOSPITAL | Madera | E220 Health Care | $46.3M | 8 |
| CALIFORNIA WESTERN SCHOOL OF LAW | San Diego | B500 Education | $46.2M | 11 |
| Kalliopeia Foundation | Inverness | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $46.1M | 6 |
| OAKWOOD SCHOOL | North Hollywood | B24Z Education | $46M | 8 |
| THE RONALD REAGAN PRESIDENTIAL | Simi Valley | B110 Education | $46M | 14 |
| CALIFORNIA HEALTH FOUNDATION AND TRUST | Sacramento | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $46M | 2 |
| THE SAN FRANCISCO SOCIETY FOR THE | San Francisco | D200 Animal-Related | $46M | 17 |
| CALIFORNIA INSTITUTE OF INTEGRAL STUDIES | San Francisco | B5XZ Education | $45.9M | 32 |
| SOUTH BAY WORKFORCE INVESTMENT BOARD INC | Hawthorne | B90 Education | $45.8M | 7 |
| WATER AND POWER COMMUNITY CREDIT UNION | Los Angeles | — | $45.7M | 12 |
| UNION RESCUE MISSION | Los Angeles | P600 Human Services | $45.7M | 9 |
| REX AND MARGARET FORTUNE SCHOOL OF | Sacramento | B25 Education | $45.7M | 8 |
| THE CHILDREN'S CLINIC | Long Beach | — | $45.7M | 11 |
| ELECTRICAL WORKERS HEALTH AND WELFARE | Pleasanton | — | $45.7M | 5 |
| LOMA LINDA UNIVERSITY BEHAVIORAL | San Bernardino | B54Z Education | $45.7M | 32 |
| CENTER THEATRE GROUP OF LOS ANGELES | Los Angeles | A650 Arts, Culture & Humanities | $45.6M | 10 |
| INTERNATIONAL UNION OF OPERATING | Pasadena | — | $45.6M | 31 |
| CARPENTERS TRAINING TRUST FUND | Oakland | J22I Employment | $45.6M | 6 |
| Quaye at Wellington Inc | San Francisco | Y11 Mutual & Membership Benefit | $45.4M | 0 |
| CEMENT MASONS HEALTH & WELFARE | Dublin | — | $45.3M | 2 |
| QUANTUM LEAP HEALTHCARE COLLABORATIVE | San Francisco | P20 Human Services | $45.1M | 11 |
| COMPLETE CARE COMMUNITY HEALTH CENTER I | Los Angeles | E20 Health Care | $45.1M | 9 |
| ROCKETSHIP EDUCATION DC PUBLIC CHARTER | San Jose | B29 Education | $45.1M | 11 |
| BABY2BABY | Los Angeles | Z99 Unknown | $45.1M | 7 |
| COLLEGE TRACK | Oakland | B82 Education | $45M | 17 |
| Central Valley Indian Health Inc | Clovis | E30Z Health Care | $45M | 21 |
| TIPPING POINT COMMUNITY | San Francisco | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $45M | 10 |
| THE HIGH DESERT PARTNERSHIP IN ACADEMIC | Apple Valley | B200 Education | $45M | 14 |
| PALISADES CHARTER HIGH SCHOOL | Pacific Palasades | B29 Education | $45M | 17 |
| LOS ANGELES JEWISH HOME FOR THE AGING | Reseda | S500 Community Improvement & Capacity Building | $44.9M | 12 |
| VENTURA COUNTY COMMUNITY FOUNDATION | Camarillo | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $44.9M | 6 |
| COALITION FOR HUMANE IMMIGRANT RIGHTS | Los Angeles | R21Z Civil Rights, Social Action & Advocacy | $44.9M | 2 |
| MONTEREY PENINSULA FOUNDATION | Monterey | T12 Philanthropy, Voluntarism & Grantmaking Foundations | $44.9M | 5 |
| ORANGE COUNTY SCHOOL OF THE ARTS | Santa Ana | B25 Education | $44.9M | 8 |
