| AbbVie Foundation | North Chicago | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $67.6M | 0 |
| Harold B Smith Foundation | Chicago | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $67.5M | 0 |
| Lions Clubs International Foundation | Oak Brook | T50 Philanthropy, Voluntarism & Grantmaking Foundations | $67.4M | 6 |
| CONCEPT SCHOOLS NFP | Schaumburg | B25 Education | $67.1M | 8 |
| NAVY PIER INC | Chicago | A80 Arts, Culture & Humanities | $66.9M | 10 |
| 1ST MIDAMERICA CREDIT UNION | Bethalto | — | $66.8M | 10 |
| FEBRES FSC FOUNDATION | Burr Ridge | — | $66.8M | 0 |
| MATHER FOUNDATION | Evanston | E19 Health Care | $66.6M | 4 |
| Kenneth C Griffin Museum of Science and Industry | Chicago | A570 Arts, Culture & Humanities | $66.4M | 11 |
| RAVINIA FESTIVAL ASSOCIATION | Highland Park | A600 Arts, Culture & Humanities | $66.2M | 7 |
| MONMOUTH COLLEGE | Monmouth | B420 Education | $66.2M | 10 |
| ILLINOIS WESLEYAN UNIVERSITY | Bloomington | B420 Education | $66.1M | 13 |
| Jo-Carroll Energy Inc (NFP) | Elizabeth | — | $66.1M | 20 |
| True Sojourners | Wheaton | Q30 International, Foreign Affairs & National Security | $65.4M | 7 |
| CENTERSTONE OF ILLINOIS INC | West Frankfort | F200 Mental Health & Crisis Intervention | $65.3M | 9 |
| UCAN | Chicago | P70Z Human Services | $65.2M | 8 |
| St Francis Hospital Sisters of the Third Order of St Francis | Litchfield | — | $65.1M | 11 |
| WOMEN'S BUSINESS DEVELOPMENT CENTER | Chicago | — | $64.8M | 6 |
| Radiological Society of North America Inc | Oak Brook | G030 Diseases, Disorders & Medical Disciplines | $64.7M | 21 |
| ILLINOIS EDUCATION ASSOCIATION | Springfield | — | $64.7M | 25 |
| Mendota Community Hospital | Peoria | E220 Health Care | $64.6M | 47 |
| STEANS FAMILY FOUNDATION | Chicago | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $64.2M | 0 |
| RICHLAND MEMORIAL HOSPITAL | Urbana | E22Z Health Care | $64M | 16 |
| The Joyce Foundation | Chicago | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $63.8M | 18 |
| CROWN FAMILY FOUNDATION | Chicago | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $63.4M | 3 |
| INTERNATIONAL UNION OF OPERATING ENGINEERS & PIPE LINE EMPLOYERS H&W FUND | Oak Brook | — | $63.4M | 0 |
| Ann & Robert H Lurie Children's Hospital of Chicago Foundation | Chicago | E110 Health Care | $63.2M | 8 |
| Stanley Manne Childrens Research Institute | Chicago | H110 Medical Research | $63.1M | 5 |
| VERSITI ILLINOIS INC | Aurora | E61Z Health Care | $63M | 17 |
| ALL CHICAGO MAKING HOMELESSNESS HISTORY | Chicago | L80 Housing & Shelter | $62.9M | 7 |
| ESPERANZA HEALTH CENTERS | Chicago | E21 Health Care | $62.8M | 9 |
| Illinois Agricultural Association | Bloomington | — | $62.7M | 41 |
| Carle West Physician Group Inc | Urbana | E20 Health Care | $62.1M | 18 |
| Tyndale House Ministries | Carol Stream | X83 Religion-Related | $62M | 19 |
| Rush University Medical Center's Self-Insurance Trust(see attachment 1) | Chicago | — | $61.7M | 1 |
| INDIVIDUAL ADVOCACY GROUP INC | Romeoville | R99 Civil Rights, Social Action & Advocacy | $61.6M | 7 |
| ELKS NATIONAL FOUNDATION INC | Chicago | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $61.6M | 2 |
| Naperville Psychiatric Ventures | Naperville | E99 Health Care | $61.5M | 20 |
| WESTMINSTER PLACE | Skokie | P750 Human Services | $61.3M | 11 |
| VNA Health Care | Aurora | — | $61.3M | 8 |
| UNIVERSITY OF CHICAGO SELF INSURANCE TRUST | Chicago | Y200 Mutual & Membership Benefit | $61M | 0 |
| Elevate Energy | Chicago | C35 Environment | $60.9M | 6 |
| ALPHA KAPPA ALPHA SORORITY INC | Chicago | — | $60.9M | 5 |
| POLISH ROMAN CATHOLIC UNION OF AMERICA | Chicago | — | $60.5M | 18 |
| MUSCULAR DYSTROPHY ASSOCIATION INC | Chicago | G50 Diseases, Disorders & Medical Disciplines | $60.4M | 8 |
| Clayton Brown Family Foundation | Wheaton | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $60.3M | 0 |
| NORTHERN ILLINOIS UNIVERSITY FOUNDATION | DeKalb | B110 Education | $60.3M | 14 |
| LUTHERAN HOME FOR THE AGED INC | Arlington Heights | P750 Human Services | $60M | 8 |
| UNITED CEREBRAL PALSY SEGUIN OF GREATER CHICAGO | Cicero | P820 Human Services | $59.9M | 8 |
| CHICAGO PAINTERS AND DECORATORS WELFARE FUND | Darien | — | $59.9M | 4 |
