| ASSYRIAN UNIVERSAL ALLIANCE FOUNDATION | Lincolnwood | Q112 International, Foreign Affairs & National Security | $59.5M | 4 |
| SHEET METAL WORKERS LOCAL 73 WELFARE FUND | Hillside | — | $59.4M | 6 |
| Deaconess Illinois Crossroads Inc | Mount Vernon | E22 Health Care | $59.4M | 5 |
| ADA S MCKINLEY COMMUNITY SERVICES INC | Chicago | P200 Human Services | $59.2M | 10 |
| CRUSADERS CENTRAL CLINIC ASSOCIATION | Rockford | E30Z Health Care | $59.1M | 15 |
| ILLINOIS COLLEGE | Jacksonville | B420 Education | $59.1M | 9 |
| National Merit Scholarship Corporation | Evanston | B820 Education | $59.1M | 8 |
| AMERICAN SOCIETY OF ANESTHESIOLOGISTS | Schaumburg | — | $58.5M | 77 |
| THE LATIN SCHOOL OF CHICAGO | Chicago | B200 Education | $58.2M | 8 |
| MISERICORDIA FOUNDATION | Chicago | P110 Human Services | $58M | 2 |
| Illinois Action for Children | Chicago | — | $58M | 8 |
| EASTER SEALS INC | Chicago | — | $58M | 11 |
| THE MORTON ARBORETUM | Lisle | C410 Environment | $57.8M | 18 |
| FERRELL HOSPITAL COMMUNITY FOUNDATION | Eldorado | E202 Health Care | $57.8M | 8 |
| Lyric Opera of Chicago | Chicago | A6A0 Arts, Culture & Humanities | $57.1M | 11 |
| Illinois Children's Healthcare Foundation | Oak Brook | P12 Human Services | $57M | 1 |
| CORPORATE AMERICA FAMILY CREDIT UNION | Elgin | — | $56.8M | 10 |
| QUINCY UNIVERSITY CORPORATION | Quincy | B420 Education | $56.5M | 7 |
| LINCOLN PARK ZOOLOGICAL SOCIETY | Chicago | D500 Animal-Related | $56.4M | 8 |
| Council for Jewish Elderly | Chicago | P750 Human Services | $56.1M | 14 |
| TRILOGY INC | Chicago | — | $56.1M | 10 |
| Illinois Life & Health Insurance Guaranty Association | Lisle | — | $55.9M | 2 |
| INTERNATIONAL UNION OF OPERATING ENGINEERS 150 | Countryside | — | $55.9M | 27 |
| Abbott Fund | Abbott Park | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $55.6M | 0 |
| KIPP CHICAGO SCHOOLS | Chicago | B29 Education | $55.3M | 7 |
| Distinctive Schools of Illinois | Chicago | B24 Education | $55.2M | 17 |
| PEKIN MEMORIAL HOSPITAL | Urbana | E220 Health Care | $55M | 19 |
| Moose International Inc | Mooseheart | — | $54.6M | 19 |
| Memorial Hospital Association | Carthage | E22 Health Care | $54.5M | 8 |
| SAMARITAN MINISTRIES INTERNATIONAL | Peoria | E80 Health Care | $54.4M | 13 |
| Greenville College | Greenville | B420 Education | $54.2M | 5 |
| UCM CARE NETWORK MEDICAL GROUP INC | Chicago | E21 Health Care | $54.1M | 21 |
| AMERICAN LIBRARY ASSOCIATION | Chicago | B030 Education | $54.1M | 11 |
| St Joseph's Hospital of the Hospital Sisters of the Third Order of St Francis | Highland | E220 Health Care | $53.9M | 10 |
| ROCHELLE COMMUNITY HOSPITAL ASSOCIATION | Rochelle | E22 Health Care | $53.9M | 9 |
| Chicago Commons Association | Chicago | P200 Human Services | $53.7M | 9 |
| NUMARK CREDIT UNION | Joliet | W61 Public & Societal Benefit | $53.6M | 10 |
| WADE MCNEILL EXEMPT UNITRUST | Chicago | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $53.5M | 0 |
| FAMILY GUIDANCE CENTERS INC | Glenview | — | $53.3M | 8 |
| UNIVERSITY OF ILLINOIS COMMUNITY CREDIT UNION | Champaign | — | $52.7M | 15 |
| ASSOCIATION FOR INDIVIDUAL DEVELOPMENT | Aurora | P82Z Human Services | $52.5M | 8 |
| THE CHRISTOPHER L & M SUSAN GUST FOUNDATION | Chicago | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $52.4M | 0 |
| Carlinville Area Hospital Association | Carlinville | E22 Health Care | $52.4M | 6 |
| ABBOTT LABORATORIES EMPLOYEES CREDIT UNION (ALEC) | Gurnee | W61 Public & Societal Benefit | $52.2M | 13 |
| PCC COMMUNITY WELLNESS CENTER | Oak Park | E320 Health Care | $52M | 11 |
| WAYNE-WHITE COUNTIES ELECTRIC COOPERATIVE INC | Fairfield | — | $52M | 16 |
| Planned Parenthood of Illinois | Chicago | E420 Health Care | $51.9M | 7 |
| Tri-County Electric Cooperative Inc | Mount Vernon | — | $51.7M | 16 |
| AMERICAN VETERINARY MEDICAL ASSOCIATION | Schaumburg | K03 Food, Agriculture & Nutrition | $51.7M | 33 |
| NORRIS ELECTRIC COOPERATIVE | Newton | — | $51.6M | 18 |
