| MILLION DOLLAR ROUND TABLE | Park Ridge | — | $85.3M | 12 |
| CONCORDIA UNIVERSITY | River Forest | B430 Education | $85.2M | 11 |
| LAWNDALE CHRISTIAN HEALTH CENTER | Chicago | — | $85.1M | 13 |
| La Rabida Children's Hospital | Chicago | E240 Health Care | $84.9M | 20 |
| Big Shoulders Fund | Chicago | B122 Education | $84.8M | 9 |
| ACCREDITATION COUNCIL FOR GRADUATE MEDICAL EDUCATION | Chicago | B50 Education | $84.7M | 7 |
| INTERNATIONAL UNION OF OPERATING ENGINEERS LOCAL 399 HEALTH & WELFARE TRU | Chicago | — | $83.8M | 4 |
| KIRBY MEDICAL CENTER | Monticello | E220 Health Care | $83.4M | 11 |
| Envision Unlimited | Chicago | P82Z Human Services | $83.3M | 10 |
| Lawndale Educational and Regional Network Charter School | Chicago | B29 Education | $83.2M | 8 |
| The YMCA of Metropolitan Chicago | Chicago | P270 Human Services | $82.8M | 16 |
| Kraft Heinz Company Retiree Health & & Welfare Benefits Trust III | Chicago | Y43 Mutual & Membership Benefit | $82.3M | 1 |
| ROSECRANCE INC | Rockford | — | $82.2M | 7 |
| Southern Illinois Medical Services NFP | Carbondale | E300 Health Care | $81.6M | 18 |
| DEVELOPMENT NOW FOR CHICAGO | Chicago | S41 Community Improvement & Capacity Building | $81.5M | 1 |
| One Hope United | Chicago | P40 Human Services | $81.3M | 9 |
| EXXON MOBIL MASTER WELFARE BENEFIT TRUST 22-05528 | Chicago | — | $81.1M | 0 |
| GREAT LAKES CREDIT UNION | Bannockburn | — | $80.7M | 12 |
| NEF COMMUNITY INVESTMENTS INC | Chicago | L20 Housing & Shelter | $80.4M | 8 |
| CHICAGO COOK WORKFORCE PARTNERSHIP | Chicago | B90 Education | $80.1M | 27 |
| Hoopeston Community Memorial Hospital | Urbana | E22Z Health Care | $79M | 28 |
| TCS Education System | Chicago | B198 Education | $78.9M | 15 |
| MCKENDREE UNIVERSITY | Lebanon | B420 Education | $78.7M | 7 |
| The International Association of Lions Clubs | Oak Brook | — | $78M | 9 |
| American Property Casualty Insurance Association | Chicago | S41 Community Improvement & Capacity Building | $77.8M | 16 |
| St Joseph's Hospital - Hospital Sisters - Third Order of St Francis | Breese | E220 Health Care | $77.8M | 10 |
| INTER-INDUSTRY CONFERENCE ON AUTO COLLISION REPAIR | Hoffman Estates | — | $77.6M | 7 |
| CLEARBROOK | Arlington Heights | P820 Human Services | $76.2M | 11 |
| ROSELAND COMMUNITY HOSPITAL ASSOCIATION | Chicago | E22Z Health Care | $75.8M | 5 |
| CHESTNUT HEALTH SYSTEMS INC | Bloomington | E70 Health Care | $75.8M | 10 |
| LOCAL NO 731 I B OF T HEALTH AND WELFARE FUND | Burr Ridge | — | $75.4M | 6 |
| SUBURBAN TEAMSTERS OF NORTHERN ILLINOIS WELFARE FUND | West Chicago | — | $75M | 7 |
| LORETTO HOSPITAL | Chicago | E220 Health Care | $74.9M | 7 |
| HEALTHCARE INFORMATION AND MANAGEMENT SYSTEMS SOCIETY | Chicago | S41 Community Improvement & Capacity Building | $74.5M | 22 |
| NORTHERN TRUST FOUNDATION | Chicago | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $74.3M | 0 |
| EASTER SEALS METROPOLITAN CHICAGO INC | Chicago | E500 Health Care | $73.8M | 7 |
| Prairie Cardiovascular Consultants Ltd | Springfield | E31 Health Care | $72.8M | 13 |
| Children's Hospital of Chicago Medical Center | Chicago | E24Z Health Care | $72.5M | 10 |
| Joint Commission Resources Inc | Oakbrook Terrace | E00B Health Care | $71.8M | 10 |
| ADVOCATE AURORA HEALTH INC | Oak Brook | E02 Health Care | $71.5M | 43 |
| KSKJ Life | Joliet | Y41Z Mutual & Membership Benefit | $70.7M | 14 |
| CENTRAL STATES JOINT BOARD HEALTH & WELFARE TRUST FUND | Hillside | — | $70.3M | 2 |
| SOUTHWESTERN ELECTRIC COOPERATIVE INC | Greenville | — | $69.8M | 17 |
| ALPHA KAPPA ALPHA SORORITYINC SUBORDINATES GROUP RETURN | Chicago | — | $69.4M | 0 |
| HEARTLAND HUMAN CARE SERVICES INC | Chicago | P610 Human Services | $68.8M | 12 |
| NATIONAL INSURANCE CRIME BUREAU | Oak Brook | — | $68.4M | 18 |
| SOCIETY OF ACTUARIES | Chicago | S41 Community Improvement & Capacity Building | $68.3M | 15 |
| CHICAGO HORTICULTURAL SOCIETY | Glencoe | C410 Environment | $68.1M | 14 |
| UNIVERSITY OF ST FRANCIS | Joliet | — | $67.8M | 9 |
| St Margaret's Health-Spring Valley | Spring Valley | E220 Health Care | $67.7M | 8 |
