| AUNT MARTHA'S HEALTH AND WELLNESS INC | Olympia Fields | P300 Human Services | $84.2M | 12 |
| INTERNATIONAL UNION OF OPERATING | Chicago | — | $83.8M | 4 |
| LORETTO HOSPITAL | Chicago | E220 Health Care | $83.7M | 9 |
| LAWNDALE EDUCATIONAL AND REGIONAL | Chicago | B29 Education | $83.1M | 8 |
| The YMCA of Metropolitan Chicago | Chicago | P270 Human Services | $82.8M | 16 |
| CNA EMPLOYEES' HEALTH PLAN TRUST | Chicago | — | $82.3M | 0 |
| CHICAGO COOK WORKFORCE PARTNERSHIP | Chicago | B90 Education | $82.3M | 21 |
| Southern Illinois Medical Services NFP | Carbondale | E300 Health Care | $81.6M | 18 |
| The Spencer Foundation | Chicago | B99Z Education | $81.5M | 13 |
| DEVELOPMENT NOW FOR CHICAGO | Chicago | S41 Community Improvement & Capacity Building | $81.5M | 1 |
| EXXON MOBIL MASTER WELFARE BENEFIT TRUST 22-05528 | Chicago | — | $81.1M | 0 |
| CHILDREN'S HOME & AID SOCIETY OF ILL | Chicago | P200 Human Services | $81M | 7 |
| Chicago Symphony Orchestra | Chicago | A690 Arts, Culture & Humanities | $80.8M | 10 |
| GREAT LAKES CREDIT UNION | Bannockburn | — | $80.7M | 12 |
| NEF COMMUNITY INVESTMENTS INC | Chicago | L20 Housing & Shelter | $80.4M | 8 |
| ILLINOIS COALITION FOR IMMIGRANT | Chicago | R21Z Civil Rights, Social Action & Advocacy | $80.4M | 3 |
| Hoopeston Community Memorial Hospital | Urbana | E22Z Health Care | $79M | 28 |
| TCS Education System | Chicago | B198 Education | $78.9M | 15 |
| ROSECRANCE INC | Rockford | — | $78M | 8 |
| One Hope United | Chicago | P40 Human Services | $77.9M | 9 |
| INTER-INDUSTRY CONFERENCE ON AUTO | Hoffman Estates | — | $77.6M | 7 |
| CLEARBROOK | Arlington Heights | P820 Human Services | $76.2M | 11 |
| ROSELAND COMMUNITY HOSPITAL ASSOCIATION | Chicago | E22Z Health Care | $75.8M | 5 |
| CHESTNUT HEALTH SYSTEMS INC | Bloomington | E70 Health Care | $75.8M | 10 |
| HEALTHCARE INFORMATION AND MANAGEMENT | Chicago | S41 Community Improvement & Capacity Building | $74.5M | 22 |
| Prairie Cardiovascular Consultants Ltd | Springfield | E31 Health Care | $74.4M | 12 |
| Adventist Health Partners Inc | La Grange | — | $74.3M | 0 |
| SUBURBAN TEAMSTERS OF NORTHERN ILLINOIS | West Chicago | — | $74.2M | 5 |
| EASTER SEALS METROPOLITAN CHICAGO INC | Chicago | E500 Health Care | $73.8M | 7 |
| LOCAL NO 731 I B OF T HEALTH | Burr Ridge | — | $73.6M | 8 |
| Children's Hospital of Chicago Medical Center | Chicago | E24Z Health Care | $72.5M | 10 |
| KIRBY MEDICAL CENTER | Monticello | E220 Health Care | $71.7M | 11 |
| ADVOCATE AURORA HEALTH INC | Oak Brook | E02 Health Care | $71.5M | 43 |
| KSKJ Life | Joliet | Y41Z Mutual & Membership Benefit | $70.7M | 14 |
| American Property Casualty Insurance Association | Chicago | S41 Community Improvement & Capacity Building | $70.4M | 16 |
| CENTRAL STATES JOINT BOARD HEALTH | Hillside | — | $70.3M | 2 |
| St Joseph's Hospital - Hospital Sisters - Third Order of St Francis | Breese | E220 Health Care | $70M | 10 |
| SOUTHWESTERN ELECTRIC COOPERATIVE INC | Greenville | — | $69.8M | 17 |
| ALPHA KAPPA ALPHA SORORITYINC | Chicago | — | $69.4M | 0 |
| DUNARD FUND USA LTD | Northbrook | — | $68.9M | 0 |
| HEARTLAND HUMAN CARE SERVICES INC | Chicago | P610 Human Services | $68.8M | 12 |
| NATIONAL INSURANCE CRIME BUREAU | Oak Brook | — | $68.4M | 18 |
| CHICAGO HORTICULTURAL SOCIETY | Glencoe | C410 Environment | $68.1M | 14 |
| UNIVERSITY OF ST FRANCIS | Joliet | — | $67.8M | 9 |
| St Margaret's Health-Spring Valley | Spring Valley | E220 Health Care | $67.7M | 8 |
| Harold B Smith Foundation | Chicago | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $67.5M | 0 |
| Lions Clubs International Foundation | Oak Brook | T50 Philanthropy, Voluntarism & Grantmaking Foundations | $67.4M | 6 |
| The International Association of Lions Clubs | Oak Brook | — | $67.3M | 9 |
| NAVY PIER INC | Chicago | A80 Arts, Culture & Humanities | $66.9M | 10 |
| 1ST MIDAMERICA CREDIT UNION | Bethalto | — | $66.8M | 10 |
