| DILLARD UNIVERSITY | New Orleans | B420 Education | $69.3M | 0 |
| EVERGREEN PRESBYTERIAN MINISTRIES INC | Haughton | P73Z Human Services | $68.5M | 8 |
| West Louisiana Health Services Inc | DeRidder | E22Z Health Care | $67.7M | 11 |
| THE GREATER NEW ORLEANS FOUNDATION | New Orleans | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $67.6M | 10 |
| COLLEGIATE ACADEMIES | New Orleans | B29 Education | $65.8M | 19 |
| OUR LADY OF THE ANGELS HOSPITAL INC | Baton Rouge | — | $65.3M | 14 |
| Access Health Louisiana | Luling | E30 Health Care | $62.9M | 13 |
| LAFAYETTE CHARTER FOUNDATION INC | Lafayette | B20 Education | $61.7M | 4 |
| LAFOURCHE PARISH HOSPITAL SERVICE DIST 1 DBA LADY OF THE SEA GENERAL HOSPITAL | Cut Off | — | $61.6M | 10 |
| Audubon Nature Institute Inc | New Orleans | D120 Animal-Related | $61.3M | 9 |
| NEW ORLEANS AND COMPANY | New Orleans | — | $61M | 14 |
| LOUISIANA ORGAN PROCUREMENT AGENCY | Covington | G44Z Diseases, Disorders & Medical Disciplines | $60.5M | 12 |
| SOUTHEASTERN LOUISIANA AREA HEALTH EDUCATION CENTER FOUNDATION | Hammond | — | $60.5M | 5 |
| HIV-AIDS Alliance for Region Two Inc | Baton Rouge | G81 Diseases, Disorders & Medical Disciplines | $59.2M | 8 |
| MARILLAC COMMUNITY HEALTH CENTERS | New Orleans | E32 Health Care | $59.2M | 10 |
| ACADIA GENERAL HOSPITAL INC | Crowley | E20 Health Care | $56M | 10 |
| FIRSTLINE SCHOOLS INC | New Orleans | B90 Education | $55.9M | 11 |
| ARKANSAS ELDER OUTREACH OF LITTLE ROCK | Baton Rouge | E91 Health Care | $55.6M | 7 |
| LAFAYETTE HEALTH VENTURES INC | Lafayette | E21 Health Care | $55M | 11 |
| START Corporation | Houma | P80 Human Services | $54.9M | 18 |
| BATON ROUGE AREA FOUNDATION | Baton Rouge | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $54.6M | 11 |
| CRESCENT CITY SCHOOLS | New Orleans | B03 Education | $53.7M | 8 |
| RAGIN' CAJUN FACILITIES INC ATTENTION SCOTT HEBERT | Lafayette | L40 Housing & Shelter | $53.2M | 0 |
| AGENDA FOR CHILDREN | New Orleans | — | $51.4M | 5 |
| FOUNDATION FOR LOUISIANA STUDENTS | Baton Rouge | B29 Education | $49.7M | 8 |
| WINN COMMUNITY HEALTH CENTER INC | Winnfield | E320 Health Care | $49.1M | 11 |
| DISCOVERY HEALTH SCIENCES FOUNDATION INC | Kenner | B29 Education | $47.8M | 3 |
| SUN BELT CONFERENCE | New Orleans | N41 Recreation & Sports | $47M | 5 |
| LIFESHARE BLOOD CENTER | Shreveport | — | $46.5M | 14 |
| LOUISIANA UNITED METHODIST CHILDREN & FAMILY SERVICES INC | Ruston | P200 Human Services | $45.9M | 4 |
| COMMUNITY SCHOOL FOR APPRENTICESHIP LEARNING | Baton Rouge | B24Z Education | $45.9M | 1 |
| LOUISIANA TECH UNIVERSITY FOUNDATION INC | Ruston | B110 Education | $45.8M | 0 |
| RENEW - REINVENTING EDUCATION | New Orleans | B29 Education | $45.3M | 10 |
| IDEA PUBLIC SCHOOLS LOUISIANA INC | Baton Rouge | B24 Education | $43.7M | 0 |
| ISIDORE NEWMAN SCHOOL | New Orleans | B200 Education | $43.6M | 9 |
| SAVOY MEDICAL MANAGMENT GROUP INC | Mamou | E22 Health Care | $43.3M | 0 |
| GOODWILL INDUSTRIES OF SOUTHEASTERN LOUISIANA INC | New Orleans | J32Z Employment | $42.1M | 7 |
| NATIONAL NETWORK OF PUBLIC HEALTH INSTITUTES INC | New Orleans | E70 Health Care | $42.1M | 8 |
| LAKE CHARLES CHARTER ACADEMY FOUNDATION INC | Lake Charles | B29 Education | $40.5M | 0 |
| NEW ORLEANS PHYSICIAN SERVICES INC | Marrero | S40 Community Improvement & Capacity Building | $40.3M | 8 |
| PROVIDENT GROUP - BISON PROPERTIES INC | Baton Rouge | B11 Education | $39.9M | 4 |
| Desoto Hospital Association Inc DBA Desoto Regional Health System | Mansfield | E220 Health Care | $39.8M | 9 |
| UNITY OF GREATER NEW ORLEANS INC | New Orleans | S50Z Community Improvement & Capacity Building | $39.8M | 1 |
| Georgia Protoncare Center Inc | Baton Rouge | E91 Health Care | $39.6M | 3 |
| ST MARTIN HOSPITAL INC | Breaux Bridge | E22 Health Care | $39M | 7 |
| CENTENARY COLLEGE OF LOUISIANA | Shreveport | — | $38.5M | 7 |
| IBERIA COMPREHENSIVE COMMUNITY HEALTH CENTER | New Iberia | — | $38.1M | 10 |
| ODYSSEY HOUSE LOUISIANA INC | New Orleans | F22 Mental Health & Crisis Intervention | $37.1M | 7 |
| Young Audiences Charter Association | Gretna | B29 Education | $36.9M | 2 |
| THE ST BERNARD PROJECT INC | New Orleans | M20 Public Safety, Disaster Preparedness & Relief | $35.3M | 7 |
