| NEIGHBORS IN NEED OF SERVICES INC | Rio Hondo | B210 Education | $28.6M | 1 |
| United Hands Relief Inc | Arlington | Q30 International, Foreign Affairs & National Security | $28.6M | 1 |
| The Cynthia & George Mitchell Foundation | The Woodlands | — | $28.4M | 7 |
| WHARTON COUNTY ELECTRIC COOPERATIVE INC | El Campo | — | $28.4M | 17 |
| SJRC TEXAS INC | Bulverde | P70Z Human Services | $28.4M | 13 |
| BROWNSVILLE COMMUNITY HEALTH CLINIC CORP | Brownsville | — | $28.3M | 10 |
| THE ONESTAR NATIONAL SERVICE | Austin | S80 Community Improvement & Capacity Building | $28.3M | 5 |
| PRESBYTERIAN CHILDREN'S HOMES & SERVICES | Austin | P730 Human Services | $28.3M | 15 |
| Texas Health Resources Foundation | Arlington | E110 Health Care | $28.2M | 17 |
| THE 1687 FOUNDATION | McKinney | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $28.2M | 7 |
| LONGHORN VILLAGE | Austin | P75 Human Services | $28.2M | 8 |
| BETTERHEALTH A PLANNED PARENTHOOD | Houston | E42 Health Care | $28.1M | 8 |
| ROLLING PLAINS MANAGEMENT CORPORATION | Crowell | P200 Human Services | $28M | 1 |
| TING TSUNG & WEI FONG CHAO FOUNDATION | Houston | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $28M | 0 |
| SOUTHWEST TEXAS ELECTRIC | Eldorado | — | $28M | 8 |
| MANVILLE WATER SUPPLY CORP | Coupland | — | $28M | 10 |
| SHARING LIFE COMMUNITY OUTREACH INC | Mesquite | P60 Human Services | $27.9M | 1 |
| SER Jobs Progress National Inc | Irving | — | $27.8M | 8 |
| Dallas Museum of Art | Dallas | A510 Arts, Culture & Humanities | $27.8M | 11 |
| Texas Agricultural Land Trust | San Antonio | C34 Environment | $27.8M | 2 |
| EARTH DAY TEXAS INC | Dallas | N52 Recreation & Sports | $27.8M | 5 |
| EDUCATIONAL LEADERSHIP INC | Houston | B20 Education | $27.7M | 6 |
| Southeast Texas Food Bank Inc | Beaumont | P20Z Human Services | $27.7M | 1 |
| STAR OF HOPE MISSION | Houston | L41 Housing & Shelter | $27.6M | 8 |
| Workforce Solutions For South Texas Inc | Laredo | J22 Employment | $27.6M | 2 |
| DNGC MEMBER CLUB INC | Dallas | N50 Recreation & Sports | $27.5M | 5 |
| Partnership With Native Americans | Addison | P20 Human Services | $27.5M | 5 |
| AUSTIN CONVENTION AND VISITORS BUREAU | Austin | — | $27.4M | 11 |
| NATIONAL DOMESTIC VIOLENCE HOTLINE | Austin | P43Z Human Services | $27.4M | 13 |
| WESLEYAN HOMES INC | Georgetown | — | $27.3M | 6 |
| AMERICA FIRST POLICY INSTITUTE INC | Fort Worth | B05 Education | $27.3M | 10 |
| WEST TEXAS FOOD BANK | Odessa | — | $27.2M | 6 |
| PIPE FITTERS LOCAL UNION #211 WELFARE | Houston | — | $27.2M | 0 |
| Advance Child Care Inc | Corsicana | P33 Human Services | $27.1M | 4 |
| CAL FARLEY'S BOYS RANCH FOUNDATION | Amarillo | P110 Human Services | $27M | 2 |
| TEXAS INSTRUMENTS FOUNDATION | Dallas | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $26.9M | 0 |
| NORTH TEXAS PUBLIC BROADCASTING INC | Dallas | A300 Arts, Culture & Humanities | $26.9M | 12 |
| SOUTHWEST CHRISTIAN SCHOOL INC | Fort Worth | B21Z Education | $26.7M | 5 |
| REGENCE HEALTH NETWORK INC | Plainview | E39Z Health Care | $26.7M | 4 |
| APV REDEVELOPMENT CORPORATION | Houston | L20 Housing & Shelter | $26.7M | 0 |
| Yoakum Community Hospital | Yoakum | — | $26.7M | 12 |
| THE LEGACY WILLOW BEND INC | Plano | P75 Human Services | $26.6M | 10 |
| Valor Texas Education Foundation | Austin | B12 Education | $26.5M | 6 |
| Hamill Foundation | Houston | — | $26.5M | 5 |
| COASTAL CONSERVATION ASSOCIATION | Houston | C013 Environment | $26.5M | 12 |
| ALLEY THEATRE | Houston | A650 Arts, Culture & Humanities | $26.3M | 8 |
| Belknap Ministries Inc | Dallas | X20 Religion-Related | $26.3M | 0 |
| HEART OF TEXAS GOODWILL INDUSTRIES INC | Waco | J32Z Employment | $26.2M | 1 |
| HOUSTON ASSOCIATION OF REALTORS | Houston | — | $26.2M | 30 |
| Bible Study Fellowship | San Antonio | X20Z Religion-Related | $26.2M | 9 |
