| HSHS Medical Group Inc | Springfield | — | $211.7M | 13 |
| THE BARACK OBAMA FOUNDATION | Chicago | A80 Arts, Culture & Humanities | $209.8M | 17 |
| Joint Commission on Accreditation of Healthcare Organizations | Oakbrook Terrace | E190 Health Care | $207.5M | 33 |
| Catholic Charities of the Archdiocese | Chicago | — | $201.5M | 17 |
| Howard Brown Health Center | Chicago | — | $201.2M | 11 |
| UNITED STATES SOCCER FEDERATION | Chicago | N640 Recreation & Sports | $196.8M | 21 |
| BEATRICE P DELANY CHAR TR XXXXX7003 | Chicago | — | $195.6M | 1 |
| NECA-IBEW WELFARE TRUST FUND | Decatur | — | $192.5M | 0 |
| Hyatt Hotels Corporation Welfare Benefit Trust | Chicago | — | $192M | 1 |
| UNITED AIRLINES PILOT RETIREE HEALTH | Chicago | Y44 Mutual & Membership Benefit | $191.2M | 0 |
| LEWIS UNIVERSITY | Romeoville | B40 Education | $189M | 10 |
| LOYOLA UNIVERSITY HEALTH SYSTEM | Maywood | E110 Health Care | $186M | 18 |
| Rush Oak Park Hospital Inc | Oak Park | E20 Health Care | $184.3M | 14 |
| THE BRINSON FOUNDATION | Chicago | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $183.6M | 1 |
| KRAFT HEINZ COMPANY GROUP BENEFIT | Chicago | — | $181.6M | 1 |
| Wheaton College | Wheaton | B420 Education | $181.6M | 16 |
| SOUTHERN ILLINOIS POWER COOPERATIVE | Marion | — | $180.8M | 11 |
| PRAIRIE POWER INC | Springfield | — | $178.8M | 25 |
| Dairy Management Inc | Rosemont | — | $178.3M | 9 |
| Edward Health Ventures | Naperville | E110 Health Care | $176.4M | 26 |
| LEROY PHILANTHROPIC TRUST XXXXX7006 | Chicago | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $176.3M | 1 |
| St Anthony's Memorial Hospital of the Hospital Sisters of The Third Order o | Effingham | E220 Health Care | $175.5M | 12 |
| FREEPORT MEMORIAL HOSPITAL | Freeport | E220 Health Care | $175.4M | 14 |
| Gibson Community Hospital Association | Gibson City | — | $174.8M | 12 |
| AURORA UNIVERSITY | Aurora | B430 Education | $173.8M | 9 |
| PIPE FITTERS' WELFARE FUND LOCAL 597 | Chicago | — | $169.2M | 6 |
| Jewish Federation of Metropolitan | Chicago | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $169.1M | 22 |
| CATHOLIC ORDER OF FORESTERS | Naperville | — | $168.5M | 32 |
| FAIRVIEW HEIGHTS MEDICAL GROUPSC | Alton | E310 Health Care | $167.7M | 6 |
| THE COMPUTING TECHNOLOGY INDUSTRY ASSOC | Downers Grove | — | $166.3M | 13 |
| ACCESS COMMUNITY HEALTH NETWORK | Chicago | E320 Health Care | $165.6M | 14 |
| Institute for the International Education of Students | Chicago | B400 Education | $164.5M | 24 |
| St Mary's Hospital Decatur of the Hospital Sisters of the Third Order of St | Decatur | E220 Health Care | $162.1M | 10 |
| EDWARD FEIN CHARITABLE TRUST XXXXX3004 | Chicago | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $161M | 1 |
| ZELL FAMILY FOUNDATION | Chicago | — | $158.4M | 0 |
| McMASTER-CARR SUPPLY CO EMPLOYEES' WELFARE TRUST | Elmhurst | — | $157.5M | 0 |
| KATHERINE SHAW BETHEA HOSPITAL | Dixon | E220 Health Care | $157.2M | 14 |
| SIU PHYSICIANS & SURGEONS INC | Springfield | E31Z Health Care | $155.6M | 22 |
| ARIE AND IDA CROWN MEMORIAL | Chicago | — | $155.2M | 0 |
| SEIU HEALTHCARE IL HOME CARE & CHILD | Chicago | Y430 Mutual & Membership Benefit | $155.1M | 4 |
| AUGUSTANA COLLEGE | Rock Island | B420 Education | $153.9M | 13 |
| National Council of YMCAs of the USA | Chicago | P270 Human Services | $153M | 8 |
| Metropolitan Family Services | Merrionette Park | P400 Human Services | $152.4M | 10 |
| HUMBOLDT PARK HEALTH | Chicago | E220 Health Care | $151.6M | 13 |
| NORTHWESTERN UNIVERSITY MASTER | Chicago | — | $151.4M | 1 |
| GOTTLIEB MEMORIAL HOSPITAL | Melrose Park | E220 Health Care | $151.3M | 18 |
| SDCO SFS Logistics Center Inc | Chicago | S47 Community Improvement & Capacity Building | $151M | 0 |
| Saint Anthony Hospital | Chicago | E210 Health Care | $150.3M | 11 |
| SEIU LOCAL 1 & PARTICIPATING EMPLOYERS | Chicago | — | $150.2M | 7 |
| Genesis Health System (IL) | Silvis | E20 Health Care | $149.7M | 12 |
