| Olivet Nazarene University | Bourbonnais | B430 Education | $148.6M | 14 |
| NORTHERN ILLINOIS FOOD BANK | Geneva | K31Z Food, Agriculture & Nutrition | $147M | 6 |
| National Louis University | Chicago | B430 Education | $146.3M | 9 |
| Rosalind Franklin University of Medicine and Science | North Chicago | — | $145.6M | 13 |
| American Hospital Association | Chicago | — | $144.7M | 31 |
| NATIONAL FUTURES ASSOCIATION | Chicago | — | $143.7M | 42 |
| GIFT OF HOPE ORGAN & TISSUE | Itasca | E65Z Health Care | $141.7M | 11 |
| Lake Forest College | Lake Forest | B420 Education | $141.5M | 17 |
| CHICAGO & VICINITY LABORERS' DISTRICT | Westchester | Y44 Mutual & Membership Benefit | $141.4M | 8 |
| AMERICAN ACADEMY OF PEDIATRICS | Itasca | G980 Diseases, Disorders & Medical Disciplines | $140.5M | 43 |
| North Central College | Naperville | B430 Education | $140.1M | 13 |
| ELMHURST UNIVERSITY | Elmhurst | — | $139.6M | 11 |
| CATERPILLAR INC GROUP INSURANCE MASTER | Chicago | — | $138.6M | 1 |
| Proctor Hospital | Urbana | E220 Health Care | $138.3M | 16 |
| THOREK MEMORIAL HOSPITAL | Chicago | E220 Health Care | $136.2M | 15 |
| National Council of State Boards | Chicago | E030 Health Care | $136M | 8 |
| Start Early | Chicago | — | $134.9M | 12 |
| Northwest Community Healthcare | Arlington Heights | E120 Health Care | $134.9M | 9 |
| GRAHAM HOSPITAL ASSOCIATION | Canton | E220 Health Care | $134.7M | 11 |
| IFF | Chicago | S500 Community Improvement & Capacity Building | $134.6M | 11 |
| Deaconess Regional Healthcare Services | Marion | E80 Health Care | $133.3M | 6 |
| IH MISSISSIPPI VALLEY CREDIT UNION | Moline | — | $131.3M | 10 |
| MISERICORDIA HOME | Chicago | P820 Human Services | $130.9M | 7 |
| SAINT XAVIER UNIVERSITY | Chicago | B430 Education | $130.4M | 11 |
| Roosevelt University | Chicago | — | $130.4M | 19 |
| Insight Chicago Inc | Chicago | E22 Health Care | $129.6M | 9 |
| AMERICAN COLLEGE OF SURGEONS | Chicago | B600 Education | $129.5M | 11 |
| EMPEOPLE CREDIT UNION | Moline | W61 Public & Societal Benefit | $129M | 15 |
| UNLIMITED DEVELOPMENT INC | Galesburg | L22 Housing & Shelter | $128.5M | 9 |
| MCGAW MEDICAL CENTER OF NORTHWESTERN UNIVERSITY | Chicago | — | $128.1M | 0 |
| HOSPITAL & MEDICAL FOUNDATION | Paris | E21Z Health Care | $128M | 9 |
| Rockford Health Physicians | Rockford | E210 Health Care | $127.9M | 10 |
| RELIGIOUS AND CHARITABLE RISK POOLING | Romeoville | X20 Religion-Related | $125.8M | 0 |
| American Bar Association Fund for Justice and Education | Chicago | I80C Crime & Legal-Related | $124.6M | 13 |
| ACERO CHARTER SCHOOLS INC | Chicago | — | $124.4M | 10 |
| CHICAGO CHARTER SCHOOL FOUNDATION | Chicago | B20 Education | $123.1M | 16 |
| St Bernard Hospital | Chicago | E220 Health Care | $122.7M | 11 |
| ADVENTIST BOLINGBROOK HOSPITAL | Bolingbrook | — | $122.5M | 0 |
| SCOTT CREDIT UNION | Edwardsville | — | $121M | 13 |
| AUTOMOBILE MECHANICS' LOCAL NO 701 | Burr Ridge | — | $120.7M | 3 |
| The Moody Bible Institute of Chicago | Chicago | B500 Education | $119.3M | 21 |
| Franciscan Communities Inc | Lemont | — | $119M | 14 |
| Institute of Gas Technology | Des Plaines | U330 Science & Technology | $118M | 17 |
| Jewish United Fund of Metropolitan | Chicago | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $117.1M | 22 |
| RML Health Providers Limited Partnership | Hinsdale | E22 Health Care | $116.9M | 16 |
| HOLY CROSS HOSPITAL | Chicago | E220 Health Care | $115.5M | 15 |
| FIELD MUSEUM OF NATURAL HISTORY | Chicago | A560 Arts, Culture & Humanities | $114.8M | 10 |
| John and Kathleen Schreiber Foundation | Lake Forest | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $112.2M | 0 |
| DOMINICAN UNIVERSITY | River Forest | B430 Education | $112.1M | 20 |
| Erie Family Health Center Inc | Chicago | E320 Health Care | $111.9M | 11 |
