| BIRTHRIGHT ISRAEL FOUNDATION | New York | Q230 International, Foreign Affairs & National Security | $85.5M | 12 |
| RAINFOREST ALLIANCE INC | New York | — | $85.5M | 11 |
| AMSTERDAM NURSING HOME | New York | E910 Health Care | $85.5M | 12 |
| THE WINDWARD SCHOOL | White Plains | B28Z Education | $85.3M | 8 |
| RETIREE HEALTH AND WELFARE FUND OF | New York | — | $85M | 6 |
| THE ROSALIND AND JOSEPH GURWIN JEWISH | Commack | E910 Health Care | $84.8M | 5 |
| THE ARC JEFFERSON-ST LAWRENCE | Watertown | P820 Human Services | $84.7M | 8 |
| ASPIRE OF WESTERN NEW YORK INC | Getzville | L80 Housing & Shelter | $84.6M | 9 |
| INTERBOROUGH DEVELOPMENTAL AND CONSULTATION | Brooklyn | F30Z Mental Health & Crisis Intervention | $84.3M | 17 |
| CATHOLIC GUARDIAN SERVICES | New York | — | $84.3M | 9 |
| GENESEE REGION HOME CARE ASSOCIATION INC | Rochester | E92Z Health Care | $84.2M | 11 |
| CITI FOUNDATION | New York | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $84.2M | 0 |
| CONCERN WORLDWIDE (US) INC | New York | Q300 International, Foreign Affairs & National Security | $84M | 7 |
| MDRC | New York | J200 Employment | $83.9M | 10 |
| THE CENTRAL EUROPEAN UNIVERSITY | New York | Q300 International, Foreign Affairs & National Security | $83.8M | 0 |
| Columbia Grammar and Preparatory School | New York | B200 Education | $83.7M | 11 |
| THE ACADEMY CHARTER SCHOOL | Hempstead | B29 Education | $83.6M | 12 |
| NATIONAL URBAN LEAGUE INC | New York | P220 Human Services | $83.4M | 6 |
| CANCER CARE CO-PAYMENT ASSISTANCE | New York | E118 Health Care | $83.4M | 6 |
| BESTSELF BEHAVIORAL HEALTH INC | Buffalo | — | $83.4M | 7 |
| MANHATTANVILLE COLLEGE | Purchase | B420 Education | $83.3M | 12 |
| Hartwick College | Oneonta | B420 Education | $82.9M | 11 |
| FOUNDATION OF THE STATE UNIVERSITY OF | Binghamton | B110 Education | $82.8M | 1 |
| UNIVERSITY AT BUFFALO FOUNDATION | Buffalo | B11 Education | $82.8M | 1 |
| NEW YORK LAW SCHOOL | New York | B500 Education | $82.8M | 9 |
| VOCATIONAL INSTRUCTION PROJECT COMMUNITY | Bronx | — | $82.7M | 10 |
| Siegel Family Endowment | New York | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $82.7M | 1 |
| THE MACMILLAN FAMILY FOUNDATION INC | New York | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $82.6M | 0 |
| THE COLLEGE OF SAINT ROSE | Albany | B430 Education | $82.4M | 10 |
| IUOE LOCAL 30 BENEFITS FUND | Whitestone | — | $82.2M | 11 |
| RISEBORO COMMUNITY PARTNERSHIP INC | Brooklyn | P810 Human Services | $82.1M | 15 |
| GRAY FOUNDATION | Albany | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $82M | 2 |
| 1199 SEIU LEAGUE TRAINING AND | New York | J200 Employment | $81.9M | 11 |
| CROHN'S & COLITIS FOUNDATION INC | New York | G70Z Diseases, Disorders & Medical Disciplines | $81.8M | 13 |
| LIVEONNY INC | Long Island City | E65 Health Care | $81.7M | 17 |
| MONDELEZ GLOBAL LLC RETIREE HEALTH AND | New York | Y43 Mutual & Membership Benefit | $81.6M | 1 |
| PEPSICO EMPLOYEES LONG TERM DISABILITY BENEFIT TRUST | Purchase | — | $81.5M | 0 |
| YEDEI CHESED INC | Chestnut Ridge | P80 Human Services | $81.3M | 6 |
| LIBERTY RESOURCES INC | Syracuse | — | $81.2M | 5 |
| B H R A G S HOMECARE INC | Brooklyn | — | $81.1M | 6 |
| CHINESE-AMERICAN PLANNING COUNCIL INC | New York | P840 Human Services | $81M | 9 |
| HAMASPIK OF ROCKLAND COUNTY INC | Monsey | Z99 Unknown | $81M | 11 |
| OHEL CHILDRENS HOME AND FAMILY SERVICES INC | Brooklyn | P70 Human Services | $80.9M | 10 |
| Mount Saint Mary College | Newburgh | B430 Education | $80.8M | 8 |
| PAVERS & ROADBUILDERS DC | Whitestone | — | $80.8M | 8 |
| MARYMOUNT MANHATTAN COLLEGE | New York | B420 Education | $80.6M | 15 |
| SULLIVAN-ORANGE-DUTCHESS COUNTIES | Monticello | — | $80.6M | 8 |
| ROYAL CHARTER PROPERTIES EAST INC | New York | E110 Health Care | $80.4M | 11 |
| NICHOLAS H NOYES MEMORIAL HOSPITAL | Dansville | E220 Health Care | $80M | 11 |
| THE NEW YORK GRACIE SQUARE HOSPITAL INC | New York | F31Z Mental Health & Crisis Intervention | $80M | 17 |
