| HSS Properties Corporation | New York | E110 Health Care | $79.7M | 6 |
| TARGET ALS FOUNDATION INC | New York | B82 Education | $79.6M | 2 |
| CITIHOPE INTERNATIONAL INC | Delhi | Q300 International, Foreign Affairs & National Security | $79.5M | 0 |
| MENORAH HOME AND HOSPITAL FOR AGED AND INFIRM | New York | E910 Health Care | $79.5M | 9 |
| STONY BROOK FOUNDATION INC | Stony Brook | B112 Education | $79.5M | 10 |
| Brooklyn Ambulatory Care PC | Westbury | E30 Health Care | $79.3M | 3 |
| MJS FOUNDATION INC | New York | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $79.2M | 1 |
| THE HUNTER COLLEGE FOUNDATION INC | New York | B114 Education | $79.2M | 4 |
| COUNCIL ON FOREIGN RELATIONS INC | New York | Q055 International, Foreign Affairs & National Security | $79.2M | 20 |
| CATHOLIC CHARITIES OF THE ROMAN | Syracuse | P20Z Human Services | $79.1M | 8 |
| UNCOMMON SCHOOLS INC | New York | B90 Education | $79.1M | 10 |
| NYSARC INC - MONTGOMERY COUNTY CHAPTER | Amsterdam | P820 Human Services | $79M | 9 |
| UFCW LOCAL 1500 WELFARE FUND | Westbury | — | $78.9M | 8 |
| William Randolph Hearst Foundation | New York | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $78.5M | 2 |
| FERNWOOD GROUP FUND | New York | — | $78.4M | 0 |
| SPONSORS FOR EDUCATIONAL OPPORTUNITY INC | New York | B900 Education | $78.3M | 15 |
| CARDIOVASCULAR RESEARCH FOUNDATION | New York | H20Z Medical Research | $78.3M | 8 |
| MEMORIAL HOSPITAL OF WILLIAM F AND | Wellsville | E22 Health Care | $78.1M | 12 |
| BOARD OF TRUSTEES OF SMW LU NO 28 | Mineola | — | $77.9M | 11 |
| THE COMMUNITY PRESERVATION CORPORATION | New York | S200 Community Improvement & Capacity Building | $77.9M | 69 |
| UNIVERSITY EMERGENCY MEDICAL | Buffalo | M99 Public Safety, Disaster Preparedness & Relief | $77.8M | 15 |
| NEW YORK CITY BALLET INC | New York | A630 Arts, Culture & Humanities | $77.4M | 10 |
| MORRIS HEIGHTS HEALTH CENTER | Bronx | E32Z Health Care | $77.4M | 13 |
| TRINITY EPISCOPAL SCHOOL | New York | B200 Education | $77.1M | 9 |
| SAINT ANN'S SCHOOL | Brooklyn | B200 Education | $76.9M | 10 |
| THE STARR FOUNDATION | New York | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $76.8M | 6 |
| CHILDREN'S RESCUE FUND | Bronx | T70Z Philanthropy, Voluntarism & Grantmaking Foundations | $76.7M | 7 |
| Montefiore Medicine Academic Health System Self Insurance Trust | Bronx | E11 Health Care | $76.5M | 1 |
| CARNEGIE CARDIOVASCULAR PC | Westbury | E30 Health Care | $76.2M | 5 |
| RUSSELL SAGE COLLEGE | Troy | B420 Education | $75.8M | 11 |
| HELEN KELLER INTERNATIONAL | New York | Q300 International, Foreign Affairs & National Security | $75.7M | 17 |
| Brooklyn Defender Services | Brooklyn | R20 Civil Rights, Social Action & Advocacy | $75.6M | 7 |
| MANHATTAN SCHOOL OF MUSIC | New York | A250 Arts, Culture & Humanities | $75.5M | 15 |
| CORPORATION FOR SUPPORTIVE HOUSING | New York | L210 Housing & Shelter | $75.3M | 8 |
| ST ANN'S HOME FOR THE AGED | Rochester | E910 Health Care | $75M | 14 |
| OPEN SPACE INSTITUTE LAND TRUST INC | New York | C340 Environment | $74.8M | 18 |
| INT'L SWAPS & DERIVATIVES ASSOCIATION INC | New York | — | $74.6M | 11 |
| THE BRIDGE INC | New York | P80Z Human Services | $74.5M | 11 |
| THE NHP FOUNDATION | New York | L200 Housing & Shelter | $74.5M | 13 |
| EXCELSIOR UNIVERSITY | Albany | B42Z Education | $74.4M | 16 |
| REHABILITATION SUPPORT SERVICES INC | Altamont | F330 Mental Health & Crisis Intervention | $74.2M | 11 |
| LORETTO INDEPENDENT LIVING SERVICES INC | North Syracuse | P75 Human Services | $74M | 1 |
| AMERICANS FOR BEN-GURION | New York | B110 Education | $74M | 7 |
| MARY MANNING WALSH NURSING HOME CO INC | New York | E910 Health Care | $73.8M | 8 |
| EQUITABLE FACILITIES FUND INC | New York | B11 Education | $73.8M | 6 |
| NEW YORK PUBLIC RADIO | New York | A340 Arts, Culture & Humanities | $73.7M | 14 |
| LORETTO HEALTH & REHABILITATION CENTER | Syracuse | E91 Health Care | $73.7M | 9 |
| C40 Cities Climate Leadership Group Inc | New York | C029 Environment | $73.6M | 8 |
| HIGHLAND PARK COMMUNITY DEVELOPMENT CORPORATION | Brooklyn | L80 Housing & Shelter | $73.6M | 14 |
| UNITED NATIONS INTERNATIONAL SCHOOL | New York | B200 Education | $73.5M | 12 |
