| THE PENNSYLVANIA HORTICULTURAL SOCIETY | Philadelphia | C420 Environment | $34.3M | 8 |
| ARTSQUEST | Bethlehem | A200 Arts, Culture & Humanities | $34.2M | 5 |
| THE ARC OF CHESTER COUNTY | West Chester | — | $34.2M | 6 |
| INDEPENDENCE MISSION SCHOOLS | Philadelphia | B24 Education | $34.1M | 5 |
| MOORE COLLEGE OF ART AND DESIGN | Philadelphia | B5XZ Education | $34M | 11 |
| INDIANA JEFFERSON ONCOLOGY LLC | Indiana | E11 Health Care | $34M | 5 |
| THE AGNES IRWIN SCHOOL | Rosemont | B200 Education | $34M | 8 |
| NRG ONCOLOGY FOUNDATION INC | Philadelphia | H30 Medical Research | $33.9M | 1 |
| HAMILTON HEALTH CENTER INC | Harrisburg | E320 Health Care | $33.9M | 9 |
| TURNING POINTS FOR CHILDREN | Philadelphia | P400 Human Services | $33.9M | 7 |
| LIFESTEPS INC | Butler | B99 Education | $33.9M | 4 |
| INDIANA HEALTHCARE PHYSICIAN SERVICES INC | Indiana | E30 Health Care | $33.8M | 9 |
| COMMUNITY AID INC | New Cumberland | P29 Human Services | $33.8M | 6 |
| Westminster Theological Seminary | Glenside | — | $33.6M | 12 |
| COMMUNITY INTERACTIONS INC | Swarthmore | P700 Human Services | $33.5M | 7 |
| PASSAVANT RETIREMENT AND HEALTH CENTER | Cranberry Township | P750 Human Services | $33.4M | 8 |
| THE ARC OF LEHIGH AND NORTHAMPTON COUNTIES INC | Bethlehem | F80 Mental Health & Crisis Intervention | $33.3M | 3 |
| ERIE HOMES FOR CHILDREN & ADULTS INC | Erie | F33Z Mental Health & Crisis Intervention | $33.3M | 2 |
| WYNCOTE FOUNDATION | Philadelphia | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $33.3M | 1 |
| MUSEUM OF THE AMERICAN REVOLUTION | Philadelphia | A54 Arts, Culture & Humanities | $33.1M | 9 |
| THE JEWISH HEALTHCARE FOUNDATION OF PITTSBURGH | Pittsburgh | E192 Health Care | $33M | 6 |
| WESTERN PENNSYLVANIA CONSERVANCY | Pittsburgh | C340 Environment | $32.8M | 12 |
| COMMUNITY ACADEMY OF PHILADELPHIA | Philadelphia | B25 Education | $32.8M | 8 |
| MAST COMMUNITY CHARTER SCHOOL III | Philadelphia | B29 Education | $32.7M | 4 |
| SCIENCE HISTORY INSTITUTE SUPPORT COMPANY | Philadelphia | B700 Education | $32.7M | 9 |
| Behavioral Health Services of Somerset & Bedford Counties | Somerset | P50 Human Services | $32.6M | 1 |
| LIBERTY RESOURCES INC | Philadelphia | — | $32.6M | 3 |
| CITIZENS ACTING TOGETHER CAN HELP INC | Philadelphia | P82Z Human Services | $32.6M | 8 |
| CENTER FOR COMMUNITY ACTION | Everett | L99Z Housing & Shelter | $32.4M | 2 |
| TRUST FOR VERIZON LONG TERM DISABILITY VEBA | Pittsburgh | — | $32.4M | 1 |
| VALLEY SPECIAL NEEDS PROGRAMS INC | Mt Pleasant | P82Z Human Services | $32.4M | 8 |
| A SECOND CHANCE INC | Pittsburgh | P300 Human Services | $32.4M | 10 |
| PETER BECKER COMMUNITY | Harleysville | Z99Z Unknown | $32.4M | 10 |
| THE KINTOCK GROUP OF NEW JERSEY INC | Fort Washington | P20 Human Services | $32.3M | 10 |
| THE PHILADELPHIA PROTESTANT HOME | Philadelphia | P750 Human Services | $32.2M | 9 |
| MORAVIAN ACADEMY | Bethlehem | — | $32.2M | 7 |
| EASTERN NATIONAL | Fort Washington | N190 Recreation & Sports | $32.2M | 9 |
| NEW FOUNDATIONS CHARTER SCHOOL | Philadelphia | B24 Education | $32M | 6 |
| ABILITIES IN MOTION | Reading | — | $32M | 1 |
| B LAB COMPANY | Philadelphia | W03 Public & Societal Benefit | $32M | 12 |
| REVIVAL TODAY INC | Coraopolis | X20 Religion-Related | $32M | 2 |
| WILLS EYE OPHTHALMOLOGY CLINIC INC | Philadelphia | H19 Medical Research | $32M | 15 |
| THE LENFEST INSTITUTE FOR JOURNALISM SPECIAL ASSET FUND OF TPF | Philadelphia | T12 Philanthropy, Voluntarism & Grantmaking Foundations | $32M | 11 |
| CHILD DEVELOPMENT CENTERS INC | Erie | — | $31.8M | 6 |
| ARMCO CREDIT UNION | Butler | — | $31.8M | 7 |
| DELTA COMMUNITY SUPPORTS INC (PA) | Blue Bell | P820 Human Services | $31.7M | 8 |
| WITTMER ZOERB FOUNDATION | Pittsburgh | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $31.6M | 0 |
| LENAPE VALLEY FOUNDATION | Doylestown | F30Z Mental Health & Crisis Intervention | $31.6M | 8 |
| BRADFORD WHITE CORPORATION HEALTH AND WELFARE TRUST | Ambler | — | $31.6M | 0 |
| LUTHERAN COMMUNITY AT TELFORD INC | Telford | P20 Human Services | $31.6M | 8 |
