| VALLEY HEALTH PARTNERS COMMUNITY HEALTH | Allentown | E32 Health Care | $36.9M | 6 |
| INGLIS HOUSE | Philadelphia | P750 Human Services | $36.5M | 10 |
| LEHIGH VALLEY ACADEMY REGIONAL | Bethlehem | B29 Education | $36.4M | 1 |
| The American College | King Of Prussia | B500 Education | $36.4M | 16 |
| THE UNITED WAY OF SOUTHWESTERN | Pittsburgh | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $36.4M | 7 |
| SPRINGBOARD COLLABORATIVE | Philadelphia | P20 Human Services | $36.3M | 6 |
| PAINTERS DISTRICT COUNCIL 711 | Philadelphia | — | $36.1M | 0 |
| CORNWALL MANOR | Cornwall | P75 Human Services | $35.9M | 14 |
| ADVANCED ROBOTICS FOR MANUFACTURING | Pittsburgh | U05 Science & Technology | $35.9M | 16 |
| PERKIOMEN SCHOOL | Pennsburg | B200 Education | $35.8M | 4 |
| Deere & Company Welfare Benefit Trust #1 | Pittsburgh | Y43 Mutual & Membership Benefit | $35.8M | 1 |
| BIBLE FELLOWSHIP CHURCH HOMES INC | Whitehall | P750 Human Services | $35.8M | 8 |
| BLUEPRINTS | Washington | S200 Community Improvement & Capacity Building | $35.7M | 6 |
| HOMELAND CENTER | Harrisburg | E910 Health Care | $35.7M | 9 |
| LYCOMING-CLINTON COUNTIES COMM FOR | Williamsport | P200 Human Services | $35.7M | 4 |
| VNA HOME HEALTH SERVICES | York | — | $35.5M | 13 |
| TROY COMMUNITY HOSPITAL | Troy | E22Z Health Care | $35.4M | 12 |
| MALVERN PREPARATORY SCHOOL | Malvern | B250 Education | $35.3M | 9 |
| Bethlehem Area School District Employee | Bethlehem | Y44 Mutual & Membership Benefit | $35.3M | 0 |
| HAZLETON PROFESSIONAL SERVICES | Allentown | — | $35.2M | 23 |
| NORTHWEST SCHOOL HEALTH CONSORTIUM | Clarion | Y44 Mutual & Membership Benefit | $35.2M | 1 |
| UNIVERSITY STUDENT HOUSING | West Chester | B42 Education | $35.1M | 3 |
| THE GRABLE FOUNDATION | Pittsburgh | — | $35M | 1 |
| Longwood at Oakmont Inc | Verona | P750 Human Services | $34.9M | 3 |
| Esperanza Academy Charter School | Philadelphia | B29 Education | $34.7M | 7 |
| MAST COMMUNITY CHARTER SCHOOL II | Philadelphia | B29 Education | $34.6M | 5 |
| PAUL'S RUN | Philadelphia | P750 Human Services | $34.6M | 9 |
| HCSC - BLOOD CENTER | Allentown | E61 Health Care | $34.5M | 7 |
| UNITED ELECTRIC COOPERATIVE INC | Du Bois | W802 Public & Societal Benefit | $34.5M | 14 |
| STAR COMMUNITY HEALTH INC | Bethlehem | E20 Health Care | $34.4M | 5 |
| ALLIED SERVICES SKILLED NURSING CENTER | Clarks Summit | E910 Health Care | $34.4M | 5 |
| TRANSCELERATE BIOPHARMA INC | West Conshohocken | H99 Medical Research | $34.2M | 8 |
| INDEPENDENCE MISSION SCHOOLS | Philadelphia | B24 Education | $34.1M | 5 |
| BRIAN'S HOUSE INC | Exton | P70Z Human Services | $34.1M | 9 |
| HAMILTON HEALTH CENTER INC | Harrisburg | E320 Health Care | $33.9M | 9 |
| COMMUNITY AID INC | New Cumberland | P29 Human Services | $33.8M | 6 |
| ERIE COMMUNITY FOUNDATION | Erie | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $33.7M | 5 |
| Asociacion De Puertorriquenos En Marcha Inc | Philadelphia | P84Z Human Services | $33.6M | 6 |
| WESTERN PENNSYLVANIA SCHOOL FOR BLIND | Pittsburgh | B280 Education | $33.6M | 7 |
| THE FREDERICK A SIMEONE MD | Philadelphia | A58Z Arts, Culture & Humanities | $33.6M | 1 |
| CAIRN UNIVERSITY | Langhorne | B500 Education | $33.5M | 4 |
| COMMUNITY INTERACTIONS INC | Swarthmore | P700 Human Services | $33.5M | 7 |
| LIBERTY RESOURCES INC | Philadelphia | — | $33.5M | 4 |
| FOUNDATION FOR INDIVIDUAL RIGHTS AND | Philadelphia | R630 Civil Rights, Social Action & Advocacy | $33.4M | 10 |
| CHILD GUIDANCE RESOURCE CENTERS | Havertown | F300 Mental Health & Crisis Intervention | $33.4M | 8 |
| THE ARC OF LEHIGH AND NORTHAMPTON | Bethlehem | F80 Mental Health & Crisis Intervention | $33.3M | 3 |
| Welfare Benefits Funding Plan for Employees of Temple University | Philadelphia | — | $33.3M | 0 |
| MORAVIAN ACADEMY | Bethlehem | — | $33.1M | 8 |
| MUSEUM OF THE AMERICAN REVOLUTION | Philadelphia | A54 Arts, Culture & Humanities | $33.1M | 9 |
| PHOEBE BERKS HEALTH CARE CENTER INC | Wernersville | E910 Health Care | $33.1M | 7 |
