| DR ALFRED A KUEHN INNOVATION INSTITUTE | Tarentum | W05 Public & Societal Benefit | $103.2M | 2 |
| JUNIATA COLLEGE | Huntingdon | B420 Education | $103.2M | 16 |
| STEAMFITTERS LU NO 420 WELFARE PLAN | Philadelphia | — | $102.9M | 5 |
| Abraxas Alliance Inc | Pittsburgh | P99 Human Services | $102.7M | 7 |
| SETON HILL UNIVERSITY | Greensburg | B420 Education | $102.6M | 10 |
| COMMUNITY CONNECTIONS FOR CHILDREN INC | York | P33B Human Services | $102.5M | 2 |
| SAINT FRANCIS UNIVERSITY | Loretto | B430 Education | $102.4M | 8 |
| Supportive Concepts for Families Inc | Reading | P820 Human Services | $102.1M | 11 |
| DELTA DENTAL OF DELAWARE INC | Camp Hill | — | $101.8M | 15 |
| CONCURRENT TECHNOLOGIES CORPORATION | Johnstown | U400 Science & Technology | $101.3M | 24 |
| DR GERTRUDE A BARBER CENTER INC | Erie | P820 Human Services | $101M | 16 |
| Delaware Valley University | Doylestown | — | $100.6M | 9 |
| Fox Chase Cancer Center Medical GroupIn | Philadelphia | E24 Health Care | $100.6M | 14 |
| THE UNIVERSITY OF THE ARTS | Philadelphia | B430 Education | $100.3M | 10 |
| ST LUKE'S HOSPITAL - CARBON CAMPUS | Allentown | E20 Health Care | $99.5M | 5 |
| ISDA FRATERNAL ASSOCIATION | Pittsburgh | — | $99.1M | 4 |
| UNIQUESOURCE PRODUCTS & SERVICES | Mechanicsburg | J330 Employment | $98.7M | 7 |
| WARREN GENERAL HOSPITAL | Warren | E220 Health Care | $98.1M | 13 |
| The Institute For Cancer Research | Philadelphia | H300 Medical Research | $98M | 17 |
| PHILADELPHIA CORPORATION FOR AGING | Philadelphia | P810 Human Services | $97.6M | 7 |
| IBEW LOCAL 98 HEALTH & WELFARE PLAN BOARD OF | Philadelphia | — | $97.5M | 3 |
| DEFENDER ASSOCIATION OF PHILADELPHIA | Philadelphia | I800 Crime & Legal-Related | $97.4M | 9 |
| GOODWILL KEYSTONE AREA | Harrisburg | J32Z Employment | $97.1M | 5 |
| TRINITY HEALTH MID-ATLANTIC MEDICAL GROUP | Langhorne | E030 Health Care | $96.9M | 13 |
| INT'L UNION OF OPERATING ENGRS WELFARE FUND OF E PA AND DE | Fort Washington | — | $96.7M | 7 |
| MISERICORDIA UNIVERSITY | Dallas | B430 Education | $96.5M | 9 |
| HOLY FAMILY UNIVERSITY | Philadelphia | B420 Education | $96.4M | 10 |
| Pennsylvania Mountains Healthcare Alliance ASO-PA Mtns Hlthcare Alliance | DuBois | Y43 Mutual & Membership Benefit | $96M | 0 |
| ACCESSLEX INSTITUTE | West Chester | W60 Public & Societal Benefit | $95.9M | 16 |
| KIMMEL CENTER INC | Philadelphia | A600 Arts, Culture & Humanities | $95.7M | 13 |
| SUMMIT PHYSICIAN SERVICES | York | — | $95.6M | 21 |
| CHEVRON PHILLIPS CHEMICAL CO LP HEALTH & | Pittsburgh | B99 Education | $95.1M | 1 |
| AMERICAN INSTITUTE FOR CHARTERED PROPERTY CASUALTY UNDERWRITERS | Malvern | Y200 Mutual & Membership Benefit | $95M | 9 |
| ANN'S CHOICE INC | Warminster | L22 Housing & Shelter | $94.7M | 8 |
| GSL HOSPITAL | Allentown | E20 Health Care | $94.4M | 1 |
| CENTER FOR ORGAN RECOVERY AND EDUCATION | Pittsburgh | E650 Health Care | $94.1M | 11 |
| ACTS COMMUNITIES OF MARYLAND INC FKA INTEGRACE INC | Fort Washington | E190 Health Care | $94M | 11 |
| Greater Philadelphia Health Action Inc | Philadelphia | — | $93.9M | 19 |
| THE HEINZ ENDOWMENTS | Pittsburgh | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $93.9M | 14 |
| SAE International | Warrendale | U030 Science & Technology | $93.7M | 11 |
| INTEALTH | Philadelphia | B900 Education | $93.6M | 13 |
| BUTLER MEDICAL PROVIDERS | Butler | E31Z Health Care | $93.2M | 13 |
| THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY | Philadelphia | H300 Medical Research | $93.1M | 15 |
| HEARTHSTONE SENIOR COMMUNITIES INC | Bala Cynwyd | E120 Health Care | $92.9M | 10 |
| KING'S COLLEGE | Wilkesbarre | B430 Education | $92.6M | 11 |
| THE GOOD SHEPHERD REHABILITATION HOSPITAL | Allentown | E24 Health Care | $92.6M | 11 |
| DISTRICT COUNCIL 47 HEALTH AND WELFARE FUND | Philadelphia | — | $92.4M | 0 |
| AMERICAN BIBLE SOCIETY | Philadelphia | X200 Religion-Related | $91.3M | 22 |
| CHATHAM UNIVERSITY | Pittsburgh | B420 Education | $90.9M | 13 |
| American Electric Power System Retiree Medical Benefit Trust | Pittsburgh | Y43 Mutual & Membership Benefit | $90.5M | 1 |
