| UPMC LITITZ | Harrisburg | E220 Health Care | $131.6M | 16 |
| CENTRAL PENNSYLVANIA TEAMSTERS HEALTH AND WELFARE FUND | Wyomissing | — | $131.6M | 11 |
| POINT PARK UNIVERSITY | Pittsburgh | — | $131.3M | 18 |
| MOUNT NITTANY MEDICAL CENTER HEALTH SERVICES INC | State College | E21 Health Care | $129.9M | 13 |
| PHILA AREA INDPDNT SCHOOL BUSINESS | Wayne | Y20 Mutual & Membership Benefit | $128.3M | 2 |
| URSINUS COLLEGE | Collegeville | B430 Education | $127.9M | 16 |
| DTCare | Moon Township | J20 Employment | $127.4M | 0 |
| WELLSPAN SURGERY & REHABILITATION HOSPITAL | York | E92 Health Care | $126M | 16 |
| UNITED STATES STEEL CORPORATION RETIREE INSURANCE BENEFITS TRUST | Pittsburgh | Y43 Mutual & Membership Benefit | $124.8M | 1 |
| LABORERS' DISTRICT COUNCIL OF WESTERN PENNSYLVANIA WELFARE FUND | Pittsburgh | — | $123.3M | 0 |
| HILLMAN FAMILY FOUNDATIONS | Pittsburgh | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $122.9M | 6 |
| LONGWOOD GARDENS INC | Kennett Square | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $121M | 2 |
| Eastern University | St Davids | B430 Education | $120.9M | 10 |
| LEBANON VALLEY COLLEGE | Annville | B42 Education | $120.6M | 18 |
| CARBON-SCHUYLKILL COMMUNITY HOSPITAL INC | Allentown | E21Z Health Care | $120.2M | 3 |
| BUCKS AND MONTGOMERY COUNTY SCHOOLS HEALTH CARE CONSORTIUM | Doylestown | Y43 Mutual & Membership Benefit | $120.1M | 0 |
| HFO FOUNDATION | Philadelphia | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $119.6M | 1 |
| Enbridge Employee Services Inc Welfare Benefit Plans Trust | Pittsburgh | — | $119.5M | 1 |
| METHODIST ASSOCIATES IN HEALTHCARE INC | Philadelphia | E31Z Health Care | $119.5M | 7 |
| PHILADELPHIA POST-ACUTE PARTNERS LLC | Philadelphia | E50 Health Care | $119.2M | 10 |
| LA SALLE UNIVERSITY | Philadelphia | B430 Education | $118.8M | 21 |
| HIGH FOUNDATION | Lancaster | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $118.8M | 9 |
| WAYNE MEMORIAL HOSPITAL | Honesdale | E220 Health Care | $116.3M | 11 |
| YOUTH ADVOCATE PROGRAMS INC | Harrisburg | P300 Human Services | $115.7M | 10 |
| PRIMARY HEALTH NETWORK | Sharon | E22Z Health Care | $114.2M | 11 |
| Marywood University | Scranton | B430 Education | $113.9M | 14 |
| AGORA CYBER CHARTER SCHOOL | King Of Prussia | B29 Education | $112.5M | 2 |
| WASHINGTON & JEFFERSON COLLEGE | Washington | B420 Education | $112.3M | 9 |
| NATIONAL CENTER FOR DEFENSE MANUFACTURING AND MACHINING | Johnstown | U40 Science & Technology | $112.2M | 21 |
| GAUDENZIA INC | Norristown | F200 Mental Health & Crisis Intervention | $112.1M | 13 |
| LAW SCHOOL ADMISSION COUNCIL C/O SUSAN KRINSKY | Newtown | B900 Education | $110.9M | 7 |
| ALVERNIA UNIVERSITY | Reading | — | $109.2M | 18 |
| WAYNESBORO HOSPITAL | York | E220 Health Care | $109.1M | 19 |
| THE WILLIAM PENN FOUNDATION | Philadelphia | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $108.9M | 8 |
| BUSINESS LEADERSHIP ORGANIZED FOR CATHOLIC SCHOOLS | King Of Prussia | B82 Education | $108.5M | 6 |
| CONCORDIA LUTHERAN MINISTRIES | Cabot | E11 Health Care | $108.1M | 3 |
| NORTHWEST BEHAVIORAL HEALTH PARTNERSHIP INC | New Castle | E80 Health Care | $107.7M | 1 |
| MERCY LIFE CENTER CORPORATION | Pittsburgh | E210 Health Care | $107.5M | 9 |
| SERVICE ACCESS & MANAGEMENT INC | Pottsville | F300 Mental Health & Crisis Intervention | $107.5M | 9 |
| DIETRICH FOUNDATION | Pittsburgh | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $107.3M | 14 |
| STEP BY STEP INC | Wilkesbarre | P820 Human Services | $107.1M | 16 |
| ELIZABETHTOWN COLLEGE | Elizabethtown | B42Z Education | $106.3M | 14 |
| KEYSTONE RURAL HEALTH CENTER | Chambersburg | E39Z Health Care | $106M | 10 |
| Philabundance | Philadelphia | K31Z Food, Agriculture & Nutrition | $106M | 7 |
| THE AMERICAN BOARD OF INTERNAL MEDICINE | Philadelphia | G95D Diseases, Disorders & Medical Disciplines | $105.8M | 29 |
| Children's Anesthesiology Associates Ltd | Philadelphia | G91Z Diseases, Disorders & Medical Disciplines | $105.5M | 18 |
| SAINT VINCENT COLLEGE | Latrobe | B420 Education | $105.1M | 8 |
| BERKS COUNTY SCHOOL DISTRICTS HEALTH TRUST | Reading | Y20 Mutual & Membership Benefit | $104.9M | 1 |
| LANSDALE HOSPITAL | Philadelphia | E20 Health Care | $104.5M | 7 |
| Greater Philadelphia Young Men's Christian Association | Conshohocken | P270 Human Services | $104.4M | 10 |
