| Permanent Endowment Fund of | Galveston | X21 Religion-Related | $312.7M | 2 |
| Brazos Electric Power Cooperative Inc | Waco | — | $312.1M | 30 |
| Methodist Healthcare Ministries of South Texas Inc | San Antonio | E120 Health Care | $312.1M | 8 |
| MAGIC VALLEY ELECTRIC COOPERATIVE INC | Mercedes | — | $311.4M | 14 |
| BLUEBONNET ELECTRIC COOPERATIVE INC | Bastrop | — | $311M | 19 |
| Baylor Scott & White Medical Centers - | Dallas | E220 Health Care | $304.9M | 19 |
| UPLIFT EDUCATION | Dallas | B20Z Education | $304.7M | 14 |
| Shannon Clinic | San Angelo | E30 Health Care | $299.9M | 25 |
| The Houston Food Bank | Houston | — | $298.5M | 13 |
| Texas Health Presbyterian Hospital Denton | Denton | E20 Health Care | $295.6M | 0 |
| TEXAS HEALTH HUGULEY INC | Burleson | E20 Health Care | $294.1M | 12 |
| Texas A&M Foundation | College Station | B43I Education | $293.3M | 10 |
| RESPONSIVEED TEXAS AMEND | Lewisville | B20 Education | $293.2M | 5 |
| Baylor Medical Center at Waxahachie | Dallas | E220 Health Care | $291.1M | 17 |
| Baylor Medical Center at Irving | Dallas | E220 Health Care | $290M | 14 |
| CATHOLIC CHARITIES DIOCESE OF FORT WORTH | Fort Worth | P20 Human Services | $289M | 11 |
| Mercy Ships International | Lindale | Q33 International, Foreign Affairs & National Security | $287.1M | 15 |
| University of the Incarnate Word | San Antonio | B430 Education | $282.3M | 17 |
| TARRANT SAFETY NET SUPPORT CORPORATION | Arlington | E19 Health Care | $278.1M | 3 |
| Lake Pointe Operating Company LLC | Dallas | E22 Health Care | $275.4M | 15 |
| Memorial Hermann Medical Group | Houston | E30 Health Care | $265M | 15 |
| YES Prep Public Schools Inc | Houston | B25P Education | $263M | 11 |
| TCH Pediatric Associates Inc | Bellaire | E32 Health Care | $261.2M | 18 |
| COMMUNITIES FOUNDATION OF TEXAS INC | Dallas | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $249.3M | 20 |
| EECU | Fort Worth | — | $246M | 28 |
| GREATER HOUSTON COMMUNITY FOUNDATION | Houston | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $242.9M | 14 |
| Northeast Texas Electric Cooperative | Longview | — | $237.9M | 13 |
| LIFESPACE COMMUNITIES INC | Dallas | P750 Human Services | $236.1M | 37 |
| CENTRAL TEXAS COMMUNITY HEALTH CENTERS | Austin | E193 Health Care | $234.9M | 17 |
| SAM HOUSTON ELECTRIC COOPERATIVE | Livingston | — | $232.2M | 26 |
| TML MULTISTATE INTERGOVERNMENTAL EMPLOYEE BENEFITS | Austin | Y44 Mutual & Membership Benefit | $229.1M | 5 |
| Florida Essential Healthcare | Austin | E12 Health Care | $227.4M | 0 |
| BOA RETIREE TRUST-BAC MEDICAL | Dallas | Y43 Mutual & Membership Benefit | $219.2M | 0 |
| EL PASOANS FIGHTING HUNGER | El Paso | K31 Food, Agriculture & Nutrition | $219M | 3 |
| KOHLS DEPARTMNT STORES INC HEALTH & | Dallas | — | $217.2M | 1 |
| PURE HANDS INC | Plano | Q33 International, Foreign Affairs & National Security | $213.8M | 1 |
| SID PETERSON MEMORIAL HOSPITAL | Kerrville | E220 Health Care | $213.3M | 11 |
| EL PASO CHILDREN'S HOSPITAL CORPORATION | El Paso | E20 Health Care | $213M | 10 |
| HOUSTON LIVESTOCK SHOW AND RODEO INC | Houston | N520 Recreation & Sports | $212.8M | 10 |
| GOODWILL INDUSTRIES OF HOUSTON | Houston | J32Z Employment | $212.6M | 14 |
| NORTH TEXAS FOOD BANK | Plano | — | $211.2M | 9 |
| GOODWILL INDUSTRIES OF CENTRAL TEXAS | Austin | J32Z Employment | $206.1M | 8 |
| DALLAS SAFETY NET SUPPORT CORPORATION | Dallas | E12 Health Care | $205.9M | 3 |
| PRESERVATION FREEHOLD COMPANY | Lewisville | L20 Housing & Shelter | $205.5M | 6 |
| FARMERS ELECTRIC COOPERATIVE INC | Greenville | — | $205.1M | 27 |
| METROPLEX ADVENTIST HOSPITAL INC | Killeen | E220 Health Care | $204.7M | 14 |
| Texas Health Harris Methodist Hospital | Fort Worth | E20 Health Care | $203.3M | 17 |
| TRINITY VALLEY ELECTRIC COOPERATIVE | Kaufman | — | $201.4M | 22 |
| GRAYSON-COLLIN ELECTRIC | Van Alstyne | — | $199.7M | 20 |
| YPO INC | Irving | — | $199.2M | 14 |
