| Baylor All Saints Medical Center | Dallas | E220 Health Care | $693.3M | 14 |
| 130 REGIONAL WATER SUPPLY CORPORATION | Round Rock | Y22 Mutual & Membership Benefit | $689M | 0 |
| SOUTH TEXAS ELECTRIC COOPERATIVE INC | Nursery | — | $688.8M | 27 |
| Baylor Health Care System Employee Benefit Trust | Dallas | Y43 Mutual & Membership Benefit | $677.4M | 1 |
| BakerRipley | Houston | P280 Human Services | $635.4M | 15 |
| Texas Health Physicians Group | Dallas | E990 Health Care | $613.4M | 30 |
| HARMONY PUBLIC SCHOOLS | Houston | B20 Education | $599.4M | 27 |
| Texas Health Presbyterian Hospital Plano | Plano | E22 Health Care | $570M | 20 |
| FAMILY ENDEAVORS INC | San Antonio | — | $569.6M | 4 |
| United Regional Health Care System | Wichita Falls | E20Z Health Care | $563.6M | 15 |
| GOLDEN SPREAD ELECTRIC COOPERATIVE INC | Amarillo | — | $545.2M | 42 |
| ELECTRIC RELIABILITY COUNCIL OF TEXAS INC | Austin | W800 Public & Societal Benefit | $543.2M | 34 |
| Christus Health Ark-La-Tex | Texarkana | E210 Health Care | $538.8M | 21 |
| American Bureau of Shipping | Spring | — | $536.6M | 36 |
| Christus Health Southeast Texas | Irving | E220 Health Care | $533.7M | 18 |
| Hillcrest Baptist Medical Center | Dallas | E220 Health Care | $522M | 16 |
| Cook Children's Physician Network | Fort Worth | E240 Health Care | $521.6M | 34 |
| ST JOSEPH REGIONAL HEALTH CENTER | Bryan | E22 Health Care | $502.3M | 13 |
| TEXAS SCOTTISH RITE HOSPITAL FOR CRIPPLED CHILDREN | Dallas | E240 Health Care | $496.2M | 27 |
| CHRONIC DISEASE FUND INC | Frisco | E600 Health Care | $493.9M | 16 |
| THE BIG 12 CONFERENCE INC | Irving | B124 Education | $493.8M | 20 |
| LAURA AND JOHN ARNOLD FOUNDATION | Houston | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $486.4M | 0 |
| KIPP Texas Inc | Houston | B24 Education | $482.4M | 17 |
| BLUEFORGE ALLIANCE | Bryan | U40 Science & Technology | $480.9M | 12 |
| Baylor Regional Medical Center at Grapevine | Dallas | E220 Health Care | $462.7M | 16 |
| BP CORPORATION NORTH AMERICA INC VEBA MASTER TRUST | Houston | Y43 Mutual & Membership Benefit | $459.8M | 1 |
| TRI-COUNTY ELECTRIC COOPERATIVE INC | Aledo | — | $454M | 21 |
| Cook Children's Health Care System | Fort Worth | E210 Health Care | $451.9M | 41 |
| Baylor Regional Medical Center at Plano | Dallas | E22 Health Care | $445.3M | 15 |
| KIMBERLY TETER PRVT BANK EST TR | San Antonio | — | $438.2M | 1 |
| Compass Connections | San Antonio | P30 Human Services | $434.3M | 9 |
| Baptist Hospitals of Southeast Texas | Beaumont | E200 Health Care | $429.7M | 16 |
| RAYBURN COUNTRY ELECTRIC COOPERATIVE INC | Rockwall | — | $412.3M | 19 |
| EAST TEXAS ELECTRIC COOP | Nacogdoches | — | $406.1M | 30 |
| Barrio Comprehensive Family Health Care Center Inc | San Antonio | E30 Health Care | $397.4M | 11 |
| Texas Health Harris Methodist Hospital Southwest Fort Worth | Fort Worth | E220 Health Care | $392.8M | 16 |
| LIFESPACE COMMUNITIES INC | Dallas | P750 Human Services | $391.2M | 28 |
| Texas Essential Healthcare Partnerships Foundation | Austin | E11 Health Care | $390.9M | 0 |
| STOLLER FOUNDATION | Houston | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $376.7M | 12 |
| LEGACY COMMUNITY HEALTH SERVICES | Houston | E30 Health Care | $370.6M | 15 |
| The Houston Food Bank | Houston | — | $366.3M | 10 |
| CATHOLIC CHARITIES DIOCESE OF FORT WORTH | Fort Worth | P20 Human Services | $365.5M | 8 |
| ABILENE CHRISTIAN UNIVERSITY | Abilene | — | $361.6M | 22 |
| Texas Health Harris Methodist Hospital Hurst-Euless-Bedford | Bedford | E220 Health Care | $359.6M | 17 |
| TEXAS DOW EMPLOYEES CREDIT UNION | Houston | — | $357.9M | 30 |
| TEXAS HEALTH HUGULEY INC | Burleson | E20 Health Care | $357.1M | 17 |
| Baylor Scott & White Medical Centers - Greater North Texas | Dallas | E220 Health Care | $354.8M | 18 |
| UNITED ELECTRIC COOPERATIVE SERVICES INC | Cleburne | Y22 Mutual & Membership Benefit | $353.4M | 25 |
| Baylor Medical Center at Irving | Dallas | E220 Health Care | $346.4M | 13 |
| GUADALUPE VALLEY ELECTRIC COOPERATIVE INC | Gonzales | Y22 Mutual & Membership Benefit | $344.4M | 23 |
