| SOUTHERN CALIFORNIA PIPE TRADES | Los Angeles | Y43 Mutual & Membership Benefit | $190.1M | 13 |
| ST JOHN'S COMMUNITY HEALTH | Los Angeles | T99Z Philanthropy, Voluntarism & Grantmaking Foundations | $187.5M | 16 |
| Point Loma Nazarene University | San Diego | B430 Education | $187.3M | 9 |
| Sharp Coronado Hospital & Healthcare Center | San Diego | — | $186.8M | 16 |
| FHCSD HOLDINGS INC | San Diego | S80 Community Improvement & Capacity Building | $186.6M | 2 |
| CALIFORNIA LUTHERAN UNIVERSITY | Thousand Oaks | B430 Education | $185.1M | 18 |
| Internet Corporation for Assigned Names and Numbers | Los Angeles | U99 Science & Technology | $184.8M | 37 |
| CHILDREN'S HUNGER FUND | Rancho Cascades | Q330 International, Foreign Affairs & National Security | $183.8M | 7 |
| UNIVERSITY OF REDLANDS | Redlands | B430 Education | $182.7M | 14 |
| FOUNDATION FOR CALIFORNIA COMMUNITY | Sacramento | B19 Education | $181.8M | 10 |
| TARZANA TREATMENT CENTERS INC | Tarzana | F34Z Mental Health & Crisis Intervention | $181.5M | 7 |
| PATH | Los Angeles | P850 Human Services | $181.1M | 7 |
| COMMUNITY PARTNERS | Los Angeles | S20 Community Improvement & Capacity Building | $180.3M | 7 |
| WIKIMEDIA FOUNDATION INC | San Francisco | B60 Education | $180.2M | 13 |
| CREDIT UNION OF SOUTHERN CALIFORNIA | Anaheim | — | $179.5M | 30 |
| IBEW LOCAL 18 HEALTH AND WELFARE TRUST | Los Angeles | — | $179.1M | 13 |
| FOREST LAWN MEMORIAL-PARK ASSOCIATION | Glendale | — | $178.4M | 24 |
| SENECA FAMILY OF AGENCIES | Oakland | — | $176.9M | 8 |
| SAN FRANCISCO CULINARY BARTENDERS & SERVICE | Pleasanton | — | $176.9M | 1 |
| FOOD FORWARD INC | North Hollywood | K30 Food, Agriculture & Nutrition | $175.2M | 7 |
| Community Health Centers of the | Santa Maria | E320 Health Care | $175M | 11 |
| OPERATING ENGINEERS LOCAL UNION NO 3 | Alameda | Y35 Mutual & Membership Benefit | $174.6M | 0 |
| ROCKETSHIP EDUCATION | San Jose | B29 Education | $173.9M | 7 |
| WRITERS GUILD - INDUSTRY HEALTH FUND | Burbank | — | $173.4M | 8 |
| PRIMA MEDICAL FOUNDATION | Novato | E300 Health Care | $172.9M | 11 |
| JEWISH COMMUNITY FOUNDATION OF SAN DIEGO | San Diego | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $172.5M | 6 |
| PREMIER AMERICA CREDIT UNION | Chatsworth | — | $172.5M | 22 |
| THE WALLIS ANNENBERG LEGACY FOUNDATION | Playa Vista | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $171.8M | 0 |
| H&H EVERGREEN FOUNDATION | Menlo Park | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $171.7M | 1 |
| NORTHEAST VALLEY HEALTH CORPORATION | San Fernando | E320 Health Care | $170.1M | 16 |
| Special Service for Groups Inc | Los Angeles | P840 Human Services | $169.9M | 14 |
| REDWOOD COAST DEVELOPMENTAL | Ukiah | — | $169.9M | 6 |
| SANTA MONICA UNITE HERE HEALTH | Los Angeles | — | $169.6M | 0 |
| COMMUNITY ACTION PARTNERSHIP OF KERN | Bakersfield | P200 Human Services | $169.2M | 12 |
| SIERRA CLUB | Oakland | — | $169M | 29 |
| CHILDREN'S HOME SOCIETY OF CALIFORNIA | Los Angeles | P300 Human Services | $168.1M | 7 |
| HENRY E HUNTINGTON LIBRARY | San Marino | A540 Arts, Culture & Humanities | $168M | 11 |
| ORANGE COUNTY COMMUNITY FOUNDATION | Irvine | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $167.9M | 9 |
| SAINT MARY'S COLLEGE OF CALIFORNIA | Moraga | B430 Education | $166.5M | 10 |
| SIERRA HEALTH FOUNDATION | Sacramento | E70 Health Care | $166.4M | 3 |
| USC VERDUGO HILLS HOSPITAL | Glendale | E20 Health Care | $166.3M | 19 |
| SAN FRANCISCO FOOD BANK | San Francisco | — | $165.7M | 11 |
| Los Angeles LGBT Center | Los Angeles | — | $162.4M | 11 |
| VALLEY CHILDREN'S MEDICAL GROUP | Madera | G98 Diseases, Disorders & Medical Disciplines | $162.2M | 9 |
| COMMUNITY HEALTH GROUP | Chula Vista | E80 Health Care | $161.5M | 20 |
| The Salk Institute for Biological Studies | La Jolla | U500 Science & Technology | $161.2M | 12 |
| WESTERN REGIONAL MEDICAL CENTER INC | Duarte | E24 Health Care | $159.3M | 18 |
| THE SAN FRANCISCO FOUNDATION | San Francisco | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $159.3M | 11 |
| MONTAGE HEALTH | Monterey | E110 Health Care | $159.1M | 11 |
| DIRECTORS GUILD OF AMERICA - PRODUCER | Los Angeles | — | $158M | 9 |
