| PETCO Animal Supplies Stores Inc | San Diego | — | $158M | 1 |
| CALIFORNIA NURSES ASSOCIATION | Oakland | — | $157.8M | 30 |
| ACADEMY OF MOTION PICTURE ARTS AND SCIENCES | Beverly Hills | — | $157.6M | 13 |
| CFHS HOLDINGS INC | Marina Del Rey | E20 Health Care | $157.5M | 13 |
| The Roberts Foundation | San Mateo | — | $156.2M | 0 |
| Monterey Bay Aquarium Foundation | Monterey | D110 Animal-Related | $155.9M | 18 |
| Fresno County Economic Opportunities | Fresno | P200 Human Services | $155.6M | 8 |
| GENE HAAS FOUNDATION | Oxnard | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $155.5M | 0 |
| DONOR NETWORK WEST | San Ramon | — | $155.1M | 16 |
| LUCAS MUSEUM OF NARRATIVE ART | Los Angeles | A50 Arts, Culture & Humanities | $154.8M | 1 |
| MARY E BAZAR-ROBIN FOUNDATION | Woodland Hills | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $154.1M | 1 |
| DAMERON HOSPITAL ASSOCIATION | Stockton | E220 Health Care | $153.9M | 6 |
| THE HELEN DILLER FOUNDATION | San Mateo | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $153.8M | 0 |
| THE EUCALYPTUS FOUNDATION | San Francisco | — | $153.8M | 1 |
| CALIFORNIA COAST CREDIT UNION | San Diego | — | $152.5M | 15 |
| THE HEISING-SIMONS FOUNDATION | Los Altos | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $152.1M | 5 |
| JEWISH COMMUNITY FOUNDATION OF LOS ANGELES | Los Angeles | T70 Philanthropy, Voluntarism & Grantmaking Foundations | $149.8M | 15 |
| PACKARD CHILDREN'S HEALTH ALLIANCE | Palo Alto | E30 Health Care | $149.4M | 18 |
| RIPPLEWORKS INC | Redwood City | Q30 International, Foreign Affairs & National Security | $149.4M | 2 |
| CENTER FOR ELDERS' INDEPENDENCE INC | Oakland | P750 Human Services | $148.9M | 10 |
| ARROWHEAD CENTRAL CREDIT UNION | Rancho Cucamonga | — | $148.2M | 16 |
| RIDGECREST REGIONAL HOSPITAL | Ridgecrest | E22 Health Care | $147.7M | 8 |
| HEALTHRIGHT 360 | San Francisco | — | $147.3M | 9 |
| LA CLINICA DE LA RAZA INC | Oakland | E300 Health Care | $147.3M | 14 |
| CHINESE HOSPITAL ASSOCIATION | San Francisco | E220 Health Care | $146.6M | 12 |
| JWCH INSTITUTE INC | Commerce | E70Z Health Care | $146.2M | 19 |
| Film Musicians Secondary Markets Fund | Encino | S41 Community Improvement & Capacity Building | $146.1M | 7 |
| ASPIRE HEALTH PLAN | Monterey | E31 Health Care | $146M | 11 |
| CLINICAS DEL CAMINO REAL INC | Ventura | E300 Health Care | $145.5M | 15 |
| CALIFORNIA TRAVEL AND TOURISM COMMISSION | Sacramento | S41 Community Improvement & Capacity Building | $145.5M | 9 |
| PROVIDENT CREDIT UNION | Redwood City | — | $145.1M | 18 |
| ART CENTER COLLEGE OF DESIGN | Pasadena | B420 Education | $145M | 13 |
| ORANGE COUNTY'S CREDIT UNION | Santa Ana | — | $143.7M | 15 |
| CALIFORNIA SVC EMPLOYEES HEALTH & WELFARE | Brisbane | — | $143.2M | 4 |
| ALTURA CREDIT UNION | Riverside | — | $142.8M | 16 |
| OPTIONS FOR LEARNING | Covina | — | $142.1M | 13 |
| Los Angeles County Fire Fighters | El Monte | — | $141.8M | 6 |
| ALADS INSURANCE TRUST | Chatsworth | — | $141.8M | 0 |
| Mexican American Opportunity Foundation | Montebello | J220 Employment | $141.2M | 7 |
| Goleta Valley Cottage Hospital | Santa Barbara | E220 Health Care | $139.7M | 12 |
| OMNI FAMILY HEALTH | Bakersfield | E320 Health Care | $139M | 8 |
| HIGHLANDS COMMUNITY CHARTER SCHOOL | Sacramento | B29 Education | $137.4M | 8 |
| WELLSPACE HEALTH | Sacramento | F220 Mental Health & Crisis Intervention | $136.5M | 13 |
| HUMANGOOD SOCAL | Duarte | P75 Human Services | $136.4M | 23 |
| TEAMSTERS AND FOOD EMPLOYERS SECURITY | West Covina | — | $136.3M | 0 |
| HAYWARD SISTERS HOSPITAL | Hayward | E20 Health Care | $136.1M | 7 |
| ABODE SERVICES | Fremont | L410 Housing & Shelter | $135.7M | 8 |
| THE JEN-HSUN & LORI HUANG FOUNDATION | Palo Alto | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $135M | 0 |
| FOOD BANK OF CONTRA COSTA AND SOLANO | Concord | K310 Food, Agriculture & Nutrition | $134.7M | 9 |
| NONPROFITS INSURANCE ALLIANCE OF | Santa Cruz | Y200 Mutual & Membership Benefit | $134.2M | 3 |
