| AGEGUIDE NORTHEASTERN ILLINOIS NE IL AREA ON AGING | Lombard | K36Z Food, Agriculture & Nutrition | $39.1M | 1 |
| PERSPECTIVES CHARTER SCHOOLS | Chicago | B25Z Education | $39.1M | 6 |
| ANDERSON HEALTHCARE | Maryville | E12 Health Care | $38.9M | 8 |
| STRUCTURAL IRON WORKERS LOCAL 1 WELFARE FUND | Forest Park | — | $38.8M | 4 |
| CHICAGO TEACHERS UNION | Chicago | — | $38.8M | 57 |
| BRAVEN INC | Chicago | O50 Youth Development | $38.7M | 8 |
| MILESTONE INC | Loves Park | P82Z Human Services | $38.7M | 5 |
| COMMUNITY INVESTMENT CORPORATION | Chicago | L200 Housing & Shelter | $38.6M | 11 |
| COMMUNITY LIVING OPTIONS INC | Galesburg | P820 Human Services | $38.6M | 6 |
| SOUTHERN ILLINOIS UNIVERSITY FOUNDATION | Carbondale | B110 Education | $38.4M | 6 |
| THE SERR CHARITABLE ACTION TRUST | Chicago | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $38.2M | 1 |
| AGEOPTIONS INC (FKA SUBURBAN AREA AGENCY ON AGING) | Oak Park | P81Z Human Services | $38.1M | 5 |
| SOUTH SIDE HEALTHY COMMUNITY ORGANIZATION | Chicago | E60 Health Care | $38.1M | 5 |
| LAKE FOREST ACADEMY | Lake Forest | B250 Education | $38.1M | 9 |
| MARION COUNTY HORIZON CENTER | Salem | E91Z Health Care | $38M | 5 |
| Jewish Child and Family Services | Chicago | P30 Human Services | $38M | 7 |
| DELTA DENTAL PLANS ASSOCIATION | Chicago | — | $38M | 14 |
| CHRISTOPHER RURAL HEALTH PLANNING CORPORATION | Christopher | E39Z Health Care | $37.9M | 7 |
| DUPAGE CREDIT UNION | Naperville | — | $37.9M | 13 |
| PrimeCare Community Health Inc | Chicago | — | $37.8M | 11 |
| MARKLUND CHILDRENS HOME | Geneva | P73Z Human Services | $37.8M | 14 |
| THE ZAKAT FOUNDATION OF AMERICA | Worth | Z99 Unknown | $37.8M | 8 |
| AFTER SCHOOL MATTERS INC | Chicago | B80 Education | $37.6M | 13 |
| DE SOLE FAMILY FOUNDATION | Chicago | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $37.6M | 0 |
| Judson University A Baptist Institution | Elgin | B420 Education | $37.4M | 4 |
| BLESSINGCARE CORPORATION | Pittsfield | E20 Health Care | $37.4M | 10 |
| FUTURE LEADERS OF AMERICA FOUNDATION INC | Chicago | B82 Education | $37.3M | 0 |
| Elim Christian Services | Crestwood | B280 Education | $37.2M | 8 |
| Illinois College of Optometry | Chicago | B500 Education | $37.1M | 13 |
| LOAVES & FISHES COMMUNITY SERVICES | Naperville | P20Z Human Services | $37M | 2 |
| YWCA METROPOLITAN CHICAGO | Chicago | P270 Human Services | $37M | 12 |
| CENTRAL ILLINOIS CARPENTERS HEALTH AND WELFARE FUND | Lincoln | — | $36.7M | 0 |
| ILLINOIS STATE UNIVERSITY FOUNDATION | Normal | B110 Education | $36.6M | 7 |
| WESTERN GOLF ASSOCIATION | Glenview | — | $36.5M | 8 |
| OSF Healthcare Foundation | Peoria | E60 Health Care | $36.4M | 2 |
| EXELON CORP EMPLOYEES BENEFITS TRUST FOR UNION EMPLOYEES | Chicago | — | $36.4M | 1 |
| PRITZKER FOUNDATION | Chicago | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $36.2M | 0 |
| RICHARD L DUCHOSSOIS FOUNDATION | Chicago | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $36.1M | 1 |
| FRIEND FAMILY HEALTH CENTER INC | Chicago | E30Z Health Care | $36M | 14 |
| Center for Housing and Health | Chicago | L99 Housing & Shelter | $35.7M | 2 |
| ACADEMY OF NUTRITION AND DIETETICS | Chicago | — | $35.7M | 15 |
| CHICAGO PUBLIC MEDIA INC | Chicago | A340 Arts, Culture & Humanities | $35.6M | 13 |
| METROPOLITAN MAYORS CAUCUS | Chicago | S21 Community Improvement & Capacity Building | $35.6M | 1 |
| AMERICAN OSTEOPATHIC ASSOCIATION | Chicago | G900 Diseases, Disorders & Medical Disciplines | $35.5M | 45 |
| ADMINISTRATIVE DISTRICT COUNCIL 1 WELFARE FUND | Elmhurst | — | $35.5M | 10 |
| HELPING HAND CENTER | Countryside | P820 Human Services | $35.4M | 7 |
| INTRINSIC SCHOOLS | Chicago | B29 Education | $35.2M | 6 |
| WESTMINSTER VILLAGE INC | Bloomington | P750 Human Services | $35.2M | 7 |
| EDWARD FEIN CHARITABLE TRUST XXXXX3004 | Chicago | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $35.2M | 1 |
| EMERSON CHARITABLE TRUST | Po Box Chica | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $34.9M | 1 |
