| HEARTLAND HEALTH SYSTEM INC | Mattoon | E22 Health Care | $38.1M | 10 |
| MARION COUNTY HORIZON CENTER | Salem | E91Z Health Care | $38M | 5 |
| DELTA DENTAL PLANS ASSOCIATION | Chicago | — | $38M | 14 |
| CHRISTOPHER RURAL HEALTH PLANNING | Christopher | E39Z Health Care | $37.9M | 7 |
| DE SOLE FAMILY FOUNDATION | Chicago | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $37.6M | 0 |
| Judson University A Baptist Institution | Elgin | B420 Education | $37.4M | 4 |
| BLESSINGCARE CORPORATION | Pittsfield | E20 Health Care | $37.4M | 10 |
| CHICAGO CONVENTION AND TOURISM BUREAU | Chicago | — | $37.3M | 13 |
| FUTURE LEADERS OF AMERICA FOUNDATION | Chicago | B82 Education | $37.3M | 0 |
| APICS INC | Chicago | — | $37.2M | 7 |
| LOAVES & FISHES COMMUNITY SERVICES | Naperville | P20Z Human Services | $37M | 2 |
| Jewish Child and Family Services | Chicago | P30 Human Services | $36.9M | 7 |
| ANDERSON HEALTHCARE | Maryville | E12 Health Care | $36.8M | 8 |
| YWCA METROPOLITAN CHICAGO | Chicago | P270 Human Services | $36.8M | 12 |
| Erikson Institute | Chicago | B300 Education | $36.7M | 11 |
| DUPAGE CREDIT UNION | Naperville | — | $36.6M | 11 |
| WESTERN GOLF ASSOCIATION | Glenview | — | $36.5M | 8 |
| LAKE FOREST ACADEMY | Lake Forest | B250 Education | $36.4M | 10 |
| OSF Healthcare Foundation | Peoria | E60 Health Care | $36.4M | 2 |
| CHILDREN'S HOME ASSOCIATION OF ILLINOIS | Peoria | P73Z Human Services | $36.3M | 9 |
| PRITZKER FOUNDATION | Chicago | — | $36.2M | 0 |
| RICHARD L DUCHOSSOIS FOUNDATION | Chicago | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $36.1M | 1 |
| FRIEND FAMILY HEALTH CENTER INC | Chicago | E30Z Health Care | $36M | 14 |
| ACADEMY OF NUTRITION AND DIETETICS | Chicago | — | $35.7M | 15 |
| METROPOLITAN MAYORS CAUCUS | Chicago | S21 Community Improvement & Capacity Building | $35.6M | 1 |
| CENTRAL ILLINOIS CARPENTERS HEALTH | Lincoln | — | $35.6M | 0 |
| AMERICAN OSTEOPATHIC ASSOCIATION | Chicago | G900 Diseases, Disorders & Medical Disciplines | $35.5M | 45 |
| ADMINISTRATIVE DISTRICT COUNCIL 1 | Elmhurst | — | $35.5M | 10 |
| AIDS Foundation of Chicago | Chicago | G81Z Diseases, Disorders & Medical Disciplines | $35.4M | 14 |
| AGEOPTIONS INC | Oak Park | P81Z Human Services | $35.1M | 5 |
| MARKLUND CHILDRENS HOME | Geneva | P73Z Human Services | $35.1M | 14 |
| MHNU Corporation | Chicago | P40 Human Services | $35M | 12 |
| EMERSON CHARITABLE TRUST | Po Box Chica | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $34.9M | 1 |
| Lurie Children's Surgical Foundation Inc | Chicago | — | $34.8M | 15 |
| HEARTLAND ALLIANCE HEALTH | Chicago | E320 Health Care | $34.7M | 12 |
| CHICAGO TEACHERS UNION | Chicago | — | $34.6M | 9 |
| United Dairy Industry Association | Rosemont | — | $34.5M | 35 |
| New Life Centers of Chicagoland | Chicago | O50 Youth Development | $34.4M | 8 |
| SERVICE EMPLOYEES' LOCAL NO 1 | Chicago | — | $34.2M | 61 |
| BUILDING MATERIAL CHAUFFEURS TMSTRS & HELPERS WELFARE FUND OF CHICAGO | Chicago | — | $34.2M | 6 |
| NATIONAL BOARD OF OSTEOPATHIC MEDICAL | Chicago | A99 Arts, Culture & Humanities | $34.1M | 27 |
| AMERICAN BOARD OF PSYCHIATRY | Deerfield | — | $34M | 25 |
| MENARD ELECTRIC COOPERATIVE | Petersburg | — | $34M | 18 |
| MERIDIAN HOSPICE | Oak Brook | — | $33.9M | 32 |
| COVENANT HEALTH CARE CENTERS INC | Northbrook | P750 Human Services | $33.8M | 12 |
| CHICAGO PUBLIC MEDIA INC | Chicago | A340 Arts, Culture & Humanities | $33.8M | 13 |
| LAND OF LINCOLN CREDIT UNION | Decatur | — | $33.7M | 8 |
| Mercy Harvard Hospital Inc | Harvard | E20Z Health Care | $33.6M | 10 |
| SMART LOCAL 265 WELFARE FUND | Carol Stream | — | $33.6M | 8 |
| MedGlobal Inc | Chicago Ridge | E70 Health Care | $33.5M | 0 |
