| CHILDREN'S HUNGER ALLIANCE | Columbus | K40Z Food, Agriculture & Nutrition | $22.9M | 5 |
| HOLMES-WAYNE ELECTRIC COOPERATIVE INC | Millersburg | — | $22.9M | 17 |
| STARK COUNTY DISTRICT LIBRARY | Canton | B71I Education | $22.8M | 2 |
| HOMELAND CREDIT UNION INC | Chillicothe | — | $22.8M | 5 |
| ROBERT ADELE SCHIFF FAMILY FDN INC | Cincinnati | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $22.8M | 0 |
| PLUMBERS & STEAMFITTERS #189 | Columbus | — | $22.7M | 3 |
| CINCINNATI USA REGIONAL CHAMBER | Cincinnati | — | $22.7M | 9 |
| United Way of Greater Cleveland | Cleveland | T70 Philanthropy, Voluntarism & Grantmaking Foundations | $22.7M | 8 |
| VICTORIA THEATRE ASSOCIATION | Dayton | A610 Arts, Culture & Humanities | $22.6M | 8 |
| JUMPSTART INC | Cleveland | S20Z Community Improvement & Capacity Building | $22.6M | 12 |
| STRS OHIO TX REAL ESTATE INVESTMENTS INC | Columbus | S47 Community Improvement & Capacity Building | $22.5M | 0 |
| METHODIST RETIREMENT CENTER OF | Columbus | P190 Human Services | $22.5M | 5 |
| THIRD STREET COMMUNITY CLINIC | Mansfield | — | $22.4M | 12 |
| OHIO NORTH EAST HEALTH SYSTEMS INC | Youngstown | E21 Health Care | $22.4M | 20 |
| CHILD FOCUS | Cincinnati | P300 Human Services | $22.3M | 6 |
| DEACONESS ASSOCIATIONS INC | Cincinnati | E110 Health Care | $22.3M | 1 |
| PROMEDICA NORTHWEST OHIO CARDIOLOGY | Toledo | E30 Health Care | $22.3M | 14 |
| THE OHIO STATE UNIVERSITY | Columbus | B84I Education | $22.2M | 0 |
| SHAREFAX CREDIT UNION INC | Cincinnati | — | $22.2M | 4 |
| St Joseph Infant and Maternity Home | Cincinnati | P730 Human Services | $22.2M | 5 |
| PLANNED PARENTHOOD OF GREATER OHIO | Columbus | E42 Health Care | $22.2M | 9 |
| Heart of Ohio Family Health Centers | Columbus | E320 Health Care | $22.1M | 10 |
| THE FOUNDATION OF THE CATHOLIC | Columbus | X112 Religion-Related | $21.9M | 5 |
| VALLEY HOSPICE INC | Rayland | — | $21.8M | 1 |
| AMISH HELPING FUND | Millersburg | — | $21.7M | 9 |
| The Huntington Foundation | Columbus | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $21.6M | 0 |
| CHILDREN'S HOME CARE OF DAYTON | Dayton | E92Z Health Care | $21.6M | 11 |
| Mercy College of Ohio | Toledo | E32I Health Care | $21.5M | 11 |
| FRONTIER COMMUNITY SERVICES | Chillicothe | P820 Human Services | $21.5M | 3 |
| FARMER FAMILY FOUNDATION | Cincinnati | — | $21.4M | 0 |
| THE AFFORDABLE HOUSING TRUST FOR | Columbus | L20 Housing & Shelter | $21.4M | 7 |
| CLEVELAND-CLIFFS STEEL LLC VEBA TRUST | Cleveland | Y43 Mutual & Membership Benefit | $21.4M | 1 |
| CLEVELAND MUSEUM OF NATURAL HISTORY | Cleveland | A560 Arts, Culture & Humanities | $21.4M | 11 |
| KENT STATE UNIVERSITY FOUNDATION | Kent | B110 Education | $21.2M | 0 |
| Wesley Community Services Organization | Cincinnati | P20 Human Services | $21.1M | 6 |
| Christ Foundation | Hartville | T50 Philanthropy, Voluntarism & Grantmaking Foundations | $21.1M | 2 |
| APPLEWOOD CENTERS INC | Shaker Heights | Z99 Unknown | $21.1M | 8 |
| IH CREDIT UNION | Springfield | — | $21M | 7 |
| School Employees Benefit Trust | Cincinnati | — | $20.9M | 0 |
| SAMARITAN BEHAVIORAL HEALTH INC | Dayton | E99 Health Care | $20.9M | 15 |
| YOUNGSTOWN AREA JEWISH FEDERATION | Youngstown | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $20.9M | 6 |
| Anne Grady Corporation | Holland | P730 Human Services | $20.8M | 3 |
| PROTECT WOMEN OHIO INC | Columbus | — | $20.8M | 0 |
| MOUNT CARMEL COLLEGE OF NURSING | Columbus | — | $20.8M | 12 |
| OHIO COMMUNITY DEVELOPMENT FINANCE FUND | Columbus | S400 Community Improvement & Capacity Building | $20.7M | 4 |
| LICKING MEMORIAL HEALTH FOUNDATION | Newark | E110 Health Care | $20.7M | 3 |
| GENFED FINANCIAL CREDIT UNION INC | Akron | — | $20.7M | 12 |
| National Board of Boiler and Pressure Vessel Inspectors | Columbus | — | $20.7M | 13 |
| ST EDWARD HOME | Fairlawn | P750 Human Services | $20.7M | 9 |
| Harrison Community Hospital | Cadiz | E22Z Health Care | $20.6M | 10 |
