| CRAFT3 | Astoria | S43 Community Improvement & Capacity Building | $53.6M | 17 |
| OREGON PUBLIC BROADCASTING | Portland | A300 Arts, Culture & Humanities | $53.1M | 12 |
| CONSUMERS POWER INC | Philomath | — | $52.7M | 17 |
| ONE COMMUNITY HEALTH | Hood River | — | $51.2M | 14 |
| GOODWILL INDUSTRIES OF LANE AND SOUTH COAST COUNTIES INC | Eugene | J32Z Employment | $50M | 5 |
| MARY'S WOODS AT MARYLHURST INC | Lake Oswego | L22 Housing & Shelter | $49.9M | 9 |
| BONNEVILLE ENVIRONMENTAL FOUNDATION | Portland | C20 Environment | $49.6M | 8 |
| MEYER MEMORIAL TRUST | Portland | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $48.7M | 6 |
| DOUGLAS FOREST PROTECTIVE ASSOCIATION | Roseburg | — | $48.7M | 6 |
| VETERANS CARE CENTERS OF OREGON | Salem | E91 Health Care | $48.1M | 7 |
| UNITED ASSOCIATION PLUMBER STMFTR & SHPFTR INDUSTRY RETIREE HEALTH TR | Tualatin | — | $47.4M | 0 |
| LEMNIS | Beaverton | B93Z Education | $45.1M | 15 |
| ACCESS | Medford | — | $44.8M | 5 |
| MIDSTATE ELECTRIC COOPERATIVE INC | La Pine | — | $44.7M | 18 |
| ALBERTINA KERR CENTERS | Portland | P730 Human Services | $44.3M | 7 |
| CATLIN GABEL SCHOOL | Portland | B200 Education | $43.5M | 7 |
| UMPQUA COMMUNITY HEALTH CENTER | Roseburg | E32Z Health Care | $43.2M | 8 |
| COOS-CURRY ELECTRIC COOPERATIVE INC | Port Orford | — | $43.1M | 18 |
| Northwest Community Credit Union | Eugene | — | $43M | 21 |
| ROGUE COMMUNITY HEALTH | Medford | E30Z Health Care | $42.6M | 12 |
| NEIGHBORIMPACT | Redmond | P280 Human Services | $42.1M | 6 |
| OREGON LABORERS - EMPLOYERS HEALTH & WELFARE TR FUND | Portland | — | $41.6M | 0 |
| PARTNERSHIPS IN COMMUNITY LIVING INC | Monmouth | P820 Human Services | $41.6M | 8 |
| BESTCARE TREATMENT SERVICES INC | Redmond | E60 Health Care | $41.1M | 9 |
| NORTHWEST ENERGY EFFICIENCY ALLIANCE | Portland | C350 Environment | $41.1M | 7 |
| PORTLAND STATE UNIVERSITY FOUNDATION | Portland | — | $40.8M | 9 |
| THE MATH LEARNING CENTER INC | Salem | U34Z Science & Technology | $40.5M | 10 |
| WILLAMETTE VIEW INC | Portland | P750 Human Services | $39.8M | 12 |
| OREGON HUMANE SOCIETY | Portland | D200 Animal-Related | $39.7M | 11 |
| CAMPAIGN FOR GREAT PUBLIC SCHOOLS | Beaverton | B01 Education | $39.6M | 8 |
| SHEET METAL WORKERS 16 HEALTH TR | Portland | — | $39M | 0 |
| NORTHWEST PORTLAND AREA INDIAN HEALTH BOARD | Portland | E70Z Health Care | $38.9M | 7 |
| Transition Projects Inc | Portland | — | $38.8M | 6 |
| PLANNED PARENTHOOD OF THE COLUMBIA WILLAMETTE INC | Portland | E420 Health Care | $38M | 8 |
| PORTLAND ART MUSEUM | Portland | A510 Arts, Culture & Humanities | $37.7M | 8 |
| JAMES F & MARION L MILLER FOUNDATION | Portland | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $37.5M | 9 |
| SAINT ALPHONSUS MEDICAL CENTER - BAKER CITY INC | Baker City | E20 Health Care | $37.4M | 10 |
| NEIGHBORHOOD HEALTH CENTER | Portland | E99 Health Care | $37.2M | 17 |
| CENTRAL WILLAMETTE CREDIT UNION | Albany | — | $36.8M | 12 |
| PROVIDENCE ST VINCENT MEDICAL FOUNDATION | Portland | E112 Health Care | $36.2M | 1 |
| Oregon Homecare Workers Benefit Trust | Portland | Y43 Mutual & Membership Benefit | $36M | 0 |
| DOVE LEWIS EMERGENCY ANIMAL HOSPITAL INC | Portland | D400 Animal-Related | $36M | 9 |
| PROVIDENCE PORTLAND MEDICAL FOUNDATION | Portland | E112 Health Care | $35.7M | 2 |
| BUSHNELL UNIVERSITY FKA NORTHWEST CHRISTIAN UNIVERSITY | Eugene | B43Z Education | $35.7M | 6 |
| MORRISON CHILD AND FAMILY SERVICES | Portland | E50 Health Care | $35.4M | 7 |
| SHEET METAL AIR RAIL AND TRANSPORTATION LOCAL 100 HEALTH BENEFIT PLAN | Portland | — | $35.3M | 0 |
| NEW NARRATIVE | Tigard | P73Z Human Services | $35.2M | 11 |
| VOCATIONAL DEVELOPMENT FOUNDATION | Portland | J30 Employment | $35.1M | 0 |
| NORTHWEST HUMAN SERVICES INC | Salem | P200 Human Services | $35.1M | 8 |
| Corban University | Salem | B42Z Education | $34.9M | 11 |
