| BONNEVILLE ENVIRONMENTAL FOUNDATION | Portland | C20 Environment | $49.6M | 8 |
| NATIONAL NETWORK OF ABORTION FUNDS INC | Beaverton | C99Z Environment | $49.2M | 11 |
| MEYER MEMORIAL TRUST | Portland | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $48.7M | 6 |
| VETERANS CARE CENTERS OF OREGON | Salem | E91 Health Care | $48.1M | 7 |
| INTEL FOUNDATION | Hillsboro | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $46.6M | 0 |
| ACCESS | Medford | — | $46.3M | 1 |
| ALBERTINA KERR CENTERS | Portland | P730 Human Services | $45.6M | 8 |
| LEMNIS | Beaverton | B93Z Education | $45.1M | 15 |
| MARY'S WOODS AT MARYLHURST INC | Lake Oswego | L22 Housing & Shelter | $44.7M | 11 |
| Oregon Homecare Workers | Portland | E03 Health Care | $43.9M | 0 |
| CATLIN GABEL SCHOOL | Portland | B200 Education | $43.5M | 7 |
| NEIGHBORIMPACT | Redmond | P280 Human Services | $43.3M | 6 |
| UMPQUA COMMUNITY HEALTH CENTER | Roseburg | E32Z Health Care | $43.2M | 8 |
| COOS-CURRY ELECTRIC COOPERATIVE INC | Port Orford | — | $43.1M | 18 |
| Northwest Community Credit Union | Eugene | — | $43M | 21 |
| OREGON LABORERS - EMPLOYERS | Portland | — | $41.6M | 0 |
| NORTHWEST ENERGY EFFICIENCY ALLIANCE | Portland | C350 Environment | $41.1M | 7 |
| PARTNERSHIPS IN COMMUNITY LIVING INC | Monmouth | P820 Human Services | $41M | 10 |
| PORTLAND STATE UNIVERSITY FOUNDATION | Portland | — | $40.8M | 9 |
| ROGUE COMMUNITY HEALTH | Medford | E30Z Health Care | $40.5M | 11 |
| THE MATH LEARNING CENTER INC | Salem | U34Z Science & Technology | $40.5M | 10 |
| MIDSTATE ELECTRIC COOPERATIVE INC | La Pine | — | $40.2M | 17 |
| WILLAMETTE VIEW INC | Portland | P750 Human Services | $39.8M | 12 |
| CAMPAIGN FOR GREAT PUBLIC SCHOOLS | Beaverton | B01 Education | $39.6M | 8 |
| NORTHWEST PORTLAND AREA INDIAN | Portland | E70Z Health Care | $38.9M | 7 |
| Transition Projects Inc | Portland | — | $38.8M | 6 |
| SAINT ALPHONSUS MEDICAL CENTER - | Baker City | — | $38.8M | 10 |
| PLANNED PARENTHOOD | Portland | E420 Health Care | $38M | 8 |
| PORTLAND ART MUSEUM | Portland | A510 Arts, Culture & Humanities | $37.7M | 8 |
| JAMES F & MARION L MILLER FOUNDATION | Portland | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $37.5M | 9 |
| NEIGHBORHOOD HEALTH CENTER | Portland | E99 Health Care | $37.2M | 17 |
| Corban University | Salem | B42Z Education | $36.3M | 10 |
| NORTHWEST HUMAN SERVICES INC | Salem | P200 Human Services | $36.2M | 7 |
| PROVIDENCE ST VINCENT MEDICAL | Portland | E112 Health Care | $36.2M | 1 |
| DOVE LEWIS EMERGENCY ANIMAL HOSPITAL INC | Portland | D400 Animal-Related | $36M | 9 |
| KLAMATH CHILD & FAMILY TREATMENT | Klamath Falls | F30Z Mental Health & Crisis Intervention | $35.9M | 5 |
| ONE COMMUNITY HEALTH | Hood River | — | $35.8M | 11 |
| MORRISON CHILD AND FAMILY SERVICES | Portland | E50 Health Care | $35.4M | 7 |
| SHEET METAL AIR RAIL AND TRANSPORTATION | Portland | — | $35.3M | 0 |
| UNITED COMMUNITY ACTION NETWORK | Roseburg | P20Z Human Services | $35M | 4 |
| BAKER CHARTER SCHOOLS ORGANIZATION | Baker City | B29 Education | $34.5M | 0 |
| SALEM ELECTRIC | Salem | — | $34M | 16 |
| METROPOLITAN PUBLIC | Portland | — | $33.5M | 8 |
| TERWILLIGER PLAZA INC | Portland | P750 Human Services | $33.2M | 8 |
| SHEET METAL WORKERS 16 HEALTH TR | Portland | — | $32.9M | 0 |
| UNITED ASSOCIATION PLUMBER STMFTR & SHPFTR | Tualatin | — | $32.7M | 0 |
| OREGON SHAKESPEARE | Ashland | A650 Arts, Culture & Humanities | $32.7M | 11 |
| LANE COMMUNITY HEALTH COUNCIL | Eugene | E02 Health Care | $32.6M | 1 |
| HACIENDA COMMUNITY DEVELOPMENT | Portland | — | $32.5M | 3 |
| Worksystems Inc | Portland | J220 Employment | $32.2M | 9 |
